FSC(PEG4-αvβ6)₃
FSC(PEG4-avb6)3 is a tracer targeting αvβ6 integrin trimer (IC50 = 0.69 nM). FSC(PEG4-avb6)3 can be used for the study of head-and-neck, lung, breast, and pancreatic carcinomas.
For research use only. We do not sell to patients.
- Formula: C237H354N54O69
- Molecular Weight:5063.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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αvβ6 0.69 nM (IC50) |
[68Ga]Ga-FSC(PEG4-avb6)3 exhibits a LogD (pH 7.4) value of -1.4, whereas [89Zr]Zr-FSC(PEG4-avb6)3 shows a LogD (pH 7.4) of -0.9[1].
[68Ga]Ga-FSC(PEG4-avb6)3 shows specific uptake of 3.9% in H2009 cells, while uptake was negligible in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft tumor-bearing models were established by subcutaneous transplantation of 5 × 106 H2009 human lung adenocarcinoma cells (αvβ6 positive) into CB17 SCID mice (female, 6-10 weeks old)[1].
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Dosage:[68Ga]Ga-FSC(PEG4-avb6)3: 120-140 pmol
[89Zr]Zr-FSC(PEG4-avb6)3: 200-400 pmol
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Administration:I.v., once
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Result:[68Ga]Ga-FSC(PEG4-avb6)3 showed tumor uptake of 1.4% ID/g.
[89Zr]Zr-FSC(PEG4-avb6)3 was suitable for extending the imaging window and showed good tumor preservation, but its stability was limited.
Chemical Information
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Molecular Weight 5063.67
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Formula C237H354N54O69
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SMILES
O=C(N(O)CCCC(NC(CCOCCOCCOCCOCCN1N=NC(CCCCC(NCCCC[C@H](N(C)C([C@@H]2CCCN2C([C@H](CC3=CC=C(O)C=C3)NC([C@H](C)N4)=O)=O)=O)C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C4=O)=O)=O)=O)=O)=O)=O)=C1)=O)C(OCC/C(C)=C\C6=O)=O)/C=C(C)\CCOC(C(NC(CCOCCOCCOCCOCCN7C=C(CCCCC(NCCCC[C@H](N(C)C([C@H]8N(C([C@H](CC9=CC=C(O)C=C9)NC([C@H](C)N%10)=O)=O)CCC8)=O)C(N[C@@H](CC%11=CC=C(O)C=C%11)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C%10=O)=O)=O)=O)=O)=O)=O)N=N7)=O)CCCN(O)C(/C=C(CCOC(C(NC(CCOCCOCCOCCOCCN%12C=C(CCCCC(NCCCC[C@H](N(C)C([C@@H]%13CCCN%13C([C@H](CC%14=CC=C(O)C=C%14)NC([C@H](C)N%15)=O)=O)=O)C(N[C@@H](CC%16=CC=C(O)C=C%16)C(N[C@@H](CCCNC(N)=N)C(NC(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C%15=O)=O)=O)=O)=O)=O)=O)N=N%12)=O)CCCN6O)=O)/C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FSC(PEG4-αvβ6)₃ Related Classifications
HY-179583 Related Classifications
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