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  2. Integrin
  3. Irigenin

Irigenin 

Cat. No.: HY-N2587
Handling Instructions

Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

For research use only. We do not sell to patients.

Irigenin Chemical Structure

Irigenin Chemical Structure

CAS No. : 548-76-5

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Description

Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].

In Vitro

Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1].

Molecular Weight

360.31

Formula

C₁₈H₁₆O₈

CAS No.

548-76-5

SMILES

O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(OC)C(O)=C13

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IrigeninIntegrinapoptosisgastriccancerTRAILEDAmetastasislungcarcinomaC-CloopEpithelial-MesenchymaltransitionInhibitorinhibitorinhibit

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