1. Cytoskeleton
  2. Integrin
  3. Irigenin

Irigenin 

Cat. No.: HY-N2587 Purity: 99.84%
Handling Instructions

Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

For research use only. We do not sell to patients.

Irigenin Chemical Structure

Irigenin Chemical Structure

CAS No. : 548-76-5

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
20 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Description

Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].

In Vitro

Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.31

Formula

C₁₈H₁₆O₈

CAS No.

548-76-5

SMILES

O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(OC)C(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

IrigeninIntegrinapoptosisgastriccancerTRAILEDAmetastasislungcarcinomaC-CloopEpithelial-MesenchymaltransitionInhibitorinhibitorinhibit

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