548-76-5
548-76-5
Chemical Structure
Irigenin
- CAS No.: 548-76-5
- Formula:C18H16O8
- Molecular Weight:360.31
IUPAC Name: 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one
InChIKey: TUGWPJJTQNLKCL-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC(OC)=C(OC)C(O)=C2)=COC3=CC(O)=C(OC)C(O)=C13
Biological Activity: Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Irigenin | 99.93% | Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Irigenin (Standard) | ≥98% | Irigenin (Standard) is the analytical standard of Irigenin. This product is intended for research and analytical applications. Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Irisflorentin | 99.76% | Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Tectorigenin | 99.89% | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Centaureidin | Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Vavain | Vavain is a natural flavonoid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Demethoxyirigenin | 6-Demethoxyirigenin is a natural flavonoid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dichotomitin | 99.02% | Dichotomitin is an isoflavonoid compound isolated from the rhizomes of Belamcanda chinensis. Dichotomitin exhibits antioxidant activity, alleviates oxidative stress, reduces intracellular reactive oxygen species (ROS) levels, and upregulates the expression of SOD1, SOD2 and CAT. Dichotomitin increases ALP activity while upregulating the expression of RUNX2, OPN and OCN. Dichotomitin has antitussive activity and helps improve symptoms of upper respiratory tract infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Irisolidone | 99.39% | Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Iristectorigenin A | 99.65% | Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Iristectorigenin B | 99.48% | Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone | 98.40% | 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a methylated flavones from Artemisia frigida. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
