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Intetumumab  (Synonyms: CNTO 95; Anti-Human CD51 Recombinant Antibody)

Cat. No.: HY-P99296 Purity: 99.24%
COA

Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer.

For research use only. We do not sell to patients.

Intetumumab Chemical Structure

Intetumumab Chemical Structure

CAS No. : 725735-28-4

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Based on 1 publication(s) in Google Scholar

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Description

Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer[1][2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Human

In Vitro

Intetumumab (CNTO 95; 0-5 μg/mL; 20 min; USPC-ARK-3 cells) inhibits integrin-mediated USPC cell adherence to a vitronectin substratum and inhibits serum-induced migration of USPC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intetumumab (CNTO 95; 10 mg/kg; i.p.; Male nude rats) inhibits tumor growth and inhibits spontaneous lung metastasis of A549 tumors and decreases both the number of rats with lung metastasis and the number of metastatic lesions per lung[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude rats with lung metastasis models (5-6 weeks old and 150-200 g)[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once a week for 60 days
Result: Had the total tumor response rates (CR and PR) was 33% in A549 tumor model.
Developed lung metastases only 4 of 9 rats.
Clinical Trial
Molecular Weight

145.6 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Intetumumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 99.24%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Intetumumab
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HY-P99296
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