GRGDSP TFA
Based on 5 publication(s) in Google Scholar
GRGDSP (TFA) is an integrin inhibitor.
For research use only. We do not sell to patients.
- Purity: 98.0%
- Formula: C24H38F3N9O12
- Molecular Weight:701.61
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GRGDSP TFA
More
Customer Validation & Images
-
IF
-
IF
-
WB
Biological Activity
Integrin[1].
It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 701.61
-
Formula C24H38F3N9O12
-
Color White to off-white
-
Sequence
Gly-Arg-Gly-Asp-Ser-Pro
-
Sequence Shortening
GRGDSP
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Theranostics
2022 Oct 17;12(17):7307-7318. PMID: 36438492
GRGDSP TFA purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
GRGDSP (1 mg/kg; inject at the injured area; single daily for 15 days) apparently reduces the densities of Mpz+, Ki67+and Sox10+ schwann cells in the injured area in the Dhhcre/+;Ninj2fl/fl mice.
GRGDSP TFA purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
Immunofluorescence staining images of NeuN and ITGB1 in the peri-infarct area. GRGDSP significantly downregulates rOPN-induced ITGB1.
GRGDSP TFA purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]
GRGDSP decreases the expression of ITGB1 in the peri-infarct area.
-
Biomed Res Int
2020 Oct 20;2020:2905634. PMID: 33134374 -
Oncol Lett
Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer. [Abstract]2023 Nov 1;26(6):538. PMID: 38020309 -
Am J Transl Res
Osteopontin-integrin signaling positively regulates neuroplasticity through enhancing neural autophagy in the peri-infarct area after ischemic stroke. [Abstract]2022 Nov 15;14(11):7726-7743. PMID: 36505285 -
bioRxiv
2025 Jul 12:2025.07.08.663758. PMID: 40672190
Solvent & Solubility
H2O : 125 mg/mL (178.16 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (71.26 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9. [Content Brief]
[2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4253 mL | 7.1265 mL | 14.2529 mL | 35.6323 mL |
| 5 mM | 0.2851 mL | 1.4253 mL | 2.8506 mL | 7.1265 mL | |
| 10 mM | 0.1425 mL | 0.7126 mL | 1.4253 mL | 3.5632 mL | |
| 15 mM | 0.0950 mL | 0.4751 mL | 0.9502 mL | 2.3755 mL | |
| 20 mM | 0.0713 mL | 0.3563 mL | 0.7126 mL | 1.7816 mL | |
| 25 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 30 mM | 0.0475 mL | 0.2375 mL | 0.4751 mL | 1.1877 mL | |
| 40 mM | 0.0356 mL | 0.1782 mL | 0.3563 mL | 0.8908 mL | |
| 50 mM | 0.0285 mL | 0.1425 mL | 0.2851 mL | 0.7126 mL | |
| 60 mM | 0.0238 mL | 0.1188 mL | 0.2375 mL | 0.5939 mL | |
| 80 mM | 0.0178 mL | 0.0891 mL | 0.1782 mL | 0.4454 mL | |
| 100 mM | 0.0143 mL | 0.0713 mL | 0.1425 mL | 0.3563 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz