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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA topoisomerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (5) DNA Glycosylase (1) DNA Methyltransferase (1) DNA-PK (2) DNA/RNA Synthesis (95) Topoisomerase (402) 5-HT Receptor (1) ADC Antibody (3) ADC Payload (56) Akt (4) Aminopeptidase (1) AMPK (4) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (111) Antibody-Drug Conjugates (ADCs) (9) AP-1 (3) Apoptosis (104) ATM/ATR (1) Autophagy (39) Bacterial (145) Bcl-2 Family (6) Biochemical Assay Reagents (2) c-Met/HGFR (1) c-Myc (3) Caspase (15) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (1) Claudin (1) Cuproptosis (1) Drug Derivative (11) Drug Intermediate (6) Drug Metabolite (3) Drug-Linker Conjugates for ADC (51) EGFR (1) Elastase (1) Endogenous Metabolite (8) Environmental Pollutants (1) ERK (2) FAK (2) Farnesyl Transferase (1) Fluorescent Dye (3) Fungal (14) HBV (3) HDAC (3) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HIV (3) IAP (1) IKK (1) Influenza Virus (3) Integrin (1) Interleukin Related (5) Isotope-Labeled Compounds (25) JNK (4) Liposome (1) MDM-2/p53 (7) MicroRNA (8) Microtubule/Tubulin (16) Mitochondrial Metabolism (12) Mitophagy (8) Mitosis (1) Mixed Lineage Kinase (1) mTOR (1) Mucin (1) Necroptosis (4) NF-κB (11) NO Synthase (1) Orthopoxvirus (9) P-glycoprotein (2) p38 MAPK (4) Parasite (26) PARP (3) PEPCK (1) Phosphatase (3) PI3K (3) PPAR (1) Reactive Oxygen Species (ROS) (29) Reference Standards (62) Reverse Transcriptase (3) RIP kinase (1) SARS-CoV (3) Sirtuin (3) SOD (1) STAT (4) Survivin (1) TNF Receptor (2) TROP2 (3) Virus Protease (1) Wnt (1) β-catenin (3)
By Research Areas:	Cancer (369) Cardiovascular Disease (11) Endocrinology (2) Infection (160) Inflammation/Immunology (38) Metabolic Disease (12) Neurological Disease (16)
Click Chemistry:	ADC Synthesis (1) DBCO (2) Alkynes (2)
Oligonucleotides:	Liposome (1) Cholesterol (1)

481

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Topoisomerase DNA-PK DNA Glycosylase DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16560

Camptothecin 65+ Cited Publications Campathecin; (S)-(+)-Camptothecin; CPT	Topoisomerase ADC Payload MicroRNA Influenza Virus Apoptosis Fungal Antibiotic	Infection Cancer
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-16562

Irinotecan 70+ Cited Publications (+)-Irinotecan; CPT-11; VAL-413free base	Topoisomerase Autophagy	Neurological Disease Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-B0879A

Suramin sodium salt 20+ Cited Publications Suramin hexasodium salt	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-128946

CL2A-SN-38 5 Publications Verification	Drug-Linker Conjugates for ADC	Inflammation/Immunology Cancer
CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects .

HY-164152A

ADC Control Human IgG1-Deruxtecan (DAR 8)	Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
ADC Control Human IgG1-Deruxtecan (DAR 8) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .

HY-15552

Podofilox 5+ Cited Publications Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-164152

ADC Control Human IgG1-Deruxtecan (DAR 4)	Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit DNA topoisomerase I. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .

HY-156617A

(αR)-Cyclopropaneacetamide-Exatecan SHR169265	ADC Payload Topoisomerase	Cancer
(αR)-Cyclopropaneacetamide-Exatecan (SHR169265) is a *DNA* Topoisomerase I inhibitor with enhanced membrane permeability (with an IC₅₀ of 1.34 μM against the human DNA Topoisomerase I). (αR)-Cyclopropaneacetamide-Exatecan exerts cytotoxic effects by inhibiting the enzymatic activity of Topoisomerase I, and this anticancer effect is independent of the expression level of HER2. (αR)-Cyclopropaneacetamide-Exatecan is an ADC Cytotoxin derived from Exatecan (HY-13631), which can be used in research related to advanced cancers such as breast cancer, gastric cancer, colorectal cancer and non-small cell lung cancer .

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-118590

ICRF-193 2 Publications Verification	Topoisomerase DNA/RNA Synthesis Apoptosis Fungal	Infection Cardiovascular Disease Inflammation/Immunology Cancer
ICRF-193 is a DNA Topoisomerase II inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .

HY-10982

Amonafide 4 Publications Verification AS1413	Topoisomerase	Cancer
Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

HY-N2108

7-Ethylcamptothecin	Drug Derivative Drug Intermediate Topoisomerase	Cancer
7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies .

HY-173634

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB (HY-173635) to make antibody agent conjugate (ADC), AZD0516 (HY-173639) .

HY-B0879

Suramin	Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-N3488

Isodiospyrin	Topoisomerase Bacterial Fungal	Infection Cancer
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase	Cardiovascular Disease Cancer
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-175203

Topi MF-6	Topoisomerase ADC Payload	Cancer
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 can be used as an ADC payload .

HY-B0268A

Enoxacin hydrate 2 Publications Verification Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate	Bacterial DNA/RNA Synthesis MicroRNA Antibiotic	Infection Cancer
Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 µg/ml) and topoisomerase IV (IC₅₀=26.5 µg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against gram-positive and -negative bacteria. Enoxacin hydrate is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0268

Enoxacin 2 Publications Verification AT 2266; CI 919	Bacterial DNA/RNA Synthesis MicroRNA Antibiotic	Infection Cancer
Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 µg/ml) and topoisomerase IV (IC₅₀=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-19024

Merbarone NSC 336628	Topoisomerase	Cancer
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent .

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-137466

ARN-21934	Topoisomerase	Cancer
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for *human topoisomerase* II α** over β. ARN-21934 inhibits DNA relaxation with an IC₅₀ of 2 μM as compared to the anticancer agent Etoposide (IC₅₀=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research .

HY-16742B

Gepotidacin mesylate hydrate 10+ Cited Publications	Antibiotic Bacterial Topoisomerase	Infection
Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase .

HY-160774

Val-Cit-PABC-DOX	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .

HY-160806

(5-Cl)-Exatecan	ADC Payload Topoisomerase	Cancer
(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a **DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1**-positive cancers .

HY-128994A

GGFG-Exatecan TFA	Drug Intermediate	Cancer
GGFG-Exatecan TFA is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs). GGFG-Exatecan TFA consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan (HY-13631). GGFG-Exatecan TFA can be used for the study of cancer .

HY-16562S1

Irinotecan-d10 hydrochloride	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-159783

Mal-Exatecan	ADC Payload Topoisomerase	Cancer
Mal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor .

HY-173703

β-Glu-PAB(CH2NH2)-Exatecan	Topoisomerase Drug Intermediate	Cancer
β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-β -Glu-Pab-Exatecan. β-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers .

HY-13727

Pixantrone free base BBR 2778 free base	Topoisomerase	Cancer
Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.

HY-128994

GGFG-Exatecan	Drug Intermediate	Cancer
GGFG-Exatecan is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs). GGFG-Exatecan consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan (HY-13631). GGFG-Exatecan can be used for the study of cancer .

HY-175700

YCJ-02	Topoisomerase Apoptosis	Cancer
YCJ-02 is a selective Topoisomerase I (Top I) inhibitor. YCJ-02 can inhibit cell proliferation and induce apoptosis and G2/M phase arrest. YCJ-02 can induce DNA damage and increaseγ-H2AX levels. YCJ-02 can promote Top I deqradation via a ubiquitin/26S proteasome pathway. YCJ-02 increases the expressions of pro-apoptotic proteins Bad, Bax, and cleaved caspase-3. YCJ-02 shows broad-spectrum antitumor activity. YCJ-02 can be used for the research of cancer, such as intrahepatic cholangiocarcinoma (ICC) .

HY-19825

Rebeccamycin	Topoisomerase ADC Payload Antibiotic	Cancer
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-125930

T-2513	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-143265

Topoisomerase I inhibitor 2	Topoisomerase Apoptosis Caspase	Cancer
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .

HY-162587

Fagopyrine	Topoisomerase	Cancer
Fagopyrine is a DNA topoisomerase I (Topo I) inhibitor. Fagopyrine is a photosensitizer that can be used in the study of tumors .

HY-W713570

Nectandrin B	Topoisomerase	Cancer
Nectandrin B is an inhibitor of DNA topoisomerases I and II, which is found in Saururus chinensis. Nectandrin B is promising for research of cancers .

HY-105293

NSC 727357	DNA/RNA Synthesis Topoisomerase	Cancer
NSC 727357 is a DNA intercalator and *topoisomerase* inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma .

HY-13727B

Pixantrone hydrochloride BBR 2778 hydrochloride	Topoisomerase	Cancer
Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity .

HY-178174

MGB4	DNA/RNA Synthesis Topoisomerase	Cancer
MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .

HY-118590A

ICRF-196	Topoisomerase DNA/RNA Synthesis Apoptosis Fungal	Infection Cardiovascular Disease Inflammation/Immunology Cancer
ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is a DNA Topoisomerase II inhibitor. ICRF-193 can inhibit DNA syntheses and induces apoptosis. ICRF-193 exhibits anti-cancer and anti-inflammation effects. ICRF-193 shows cardioprotective effect against anthracycline toxicity to cardiomyocytes. ICRF-193 can be used for the researches of cancer, infection, inflammation and cardiovascular disease, such as acute promyelocytic leukemia .

HY-175269

MGB1Y	DNA Alkylator/Crosslinker DNA/RNA Synthesis Topoisomerase	Cancer
MGB1Y is a noncovalent *DNA* minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia .

HY-B0879AR

Suramin sodium salt (Standard) Suramin hexasodium salt (Standard)	Reference Standards Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Suramin (sodium salt) (Standard) is the analytical standard of Suramin (sodium salt). This product is intended for research and analytical applications. Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-N15319

Eupolauridine Canangine	Topoisomerase Fungal	Infection
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC₅₀ values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases .

HY-123363

Tafluposide F-11782	Topoisomerase	Cancer
Tafluposide (F-11782) is a **DNA topoisomerase** inhibitor. Tafluposide has antitumor activity .

HY-174227

Topoisomerase inhibitor 6	Topoisomerase Bacterial	Infection
Topoisomerase inhibitor 6 (Compound REDX05931) is a dual irreversible inhibitor of DNA gyrase and topoisomerase IV (MIC=0.06 μg/mL against fluoroquinolone-resistant S. aureus). Topoisomerase inhibitor 6 blocks DNA strand break-reunion, inducing lethal DNA damage. Topoisomerase inhibitor 6 is promising for research of Gram-positive bacterial infections (e.g., S. aureus, S. pneumoniae) .

HY-125930A

T-2513 hydrochloride	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-162381

Topoisomerase II inhibitor 19	Topoisomerase	Cancer
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and topoisomerase II inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA .

HY-120747

A-65282	Bacterial DNA/RNA Synthesis	Infection
A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC₅₀ value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Disease Research Fields Source Classification	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-13629

Etoposide 170+ Cited Publications VP-16; VP-16-213	Infection Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13704

SN-38 65+ Cited Publications 7-Ethyl-10-hydroxycamptothecin	Alkaloids Structural Classification Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Drug Metabolite Topoisomerase ADC Payload Autophagy
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits *DNA* and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-16560

Camptothecin 65+ Cited Publications Campathecin; (S)-(+)-Camptothecin; CPT	Infection Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields	Topoisomerase ADC Payload MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-18258

Berberine chloride 75+ Cited Publications Natural Yellow 18 chloride	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits **DNA topoisomerase**. Antineoplastic properties .

HY-13062

Daunorubicin hydrochloride 35+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N0716B

Berberine sulfate 75+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits **DNA topoisomerase**. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-13062A

Daunorubicin 35+ Cited Publications Daunomycin; RP 13057; Rubidomycin	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-17577

Berberine chloride hydrate 70+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits **DNA topoisomerase**. Antineoplastic properties .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15552

Podofilox 5+ Cited Publications Podophyllotoxin	Classification of Application Fields Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-B0398

Nalidixic acid 2 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic Topoisomerase
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Classification of Application Fields Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Source Classification Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-B0147

Pefloxacin 3 Publications Verification Pefloxacinium	Infection Classification of Application Fields Disease Research Fields	Antibiotic Bacterial Parasite DNA/RNA Synthesis Topoisomerase
Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-N0095

(S)-10-Hydroxycamptothecin 1 Publications Verification 10-HCPT; 10-Hydroxycamptothecin	Alkaloids Monophenols Pyrrole Alkaloids Classification of Application Fields Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase Apoptosis
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment .

HY-N0498

Nitidine chloride 4 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-13744

Rubitecan RFS 2000; 9-Nitrocamptothecin	Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase
Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells .

HY-N0716

Berberine Natural Yellow 18	Classification of Application Fields Anti-aging Ranunculaceae Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits **DNA topoisomerase**. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0354

Anthraquinone 3 Publications Verification	Seeds of Cassia tora Linn. Quinones Structural Classification other families Classification of Application Fields Leguminosae Anthraquinones Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants Virus Protease
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .

HY-N2108

7-Ethylcamptothecin	Alkaloids Structural Classification other families Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Drug Derivative Drug Intermediate Topoisomerase
7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies .

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Classification of Application Fields Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer Source Classification	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-N3488

Isodiospyrin	Quinones other families Diospyros virginiana L. Benzene Quinones Plants Source Classification	Topoisomerase Bacterial Fungal
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Source Classification Cancer	Interleukin Related DNA/RNA Synthesis Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Plants Lauraceae Disease Research Fields Source Classification Cancer	Apoptosis NF-κB Topoisomerase Mitochondrial Metabolism Caspase
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound that can be isolated from Cinnamomum cassia. 2-Methoxycinnamaldehyde inhibits *topoisomerase-I/II* and NF-κB signaling pathway, causes mitochondrial dysfunction, induces lysosomal vesiculation, thereby leading to DNA damage and cell apoptosis. 2-Methoxycinnamaldehyde exhibits antitumor effects .

HY-N1457

Chrysosplenetin 3 Publications Verification	Flavonols Structural Classification Piscidia erythrina L. Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields Source Classification	P-glycoprotein Topoisomerase Apoptosis DNA/RNA Synthesis Wnt β-catenin Parasite
Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting *topoisomerase, protecting DNA* and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the Wnt/β-catenin pathway and exerts anti-osteoporotic effects .

HY-13704R

SN-38 (Standard) 7-Ethyl-10-hydroxycamptothecin (Standard)	Alkaloids Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Source Classification	Drug Metabolite Reference Standards Topoisomerase ADC Payload Autophagy
SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-Y0191

α-Pyridone 2-Pyridone	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial
α-Pyridone (2-Pyridone) is an antibacterial agent that plays an important role in the field of biochemical research. α-Pyridone can serve as a scaffold compound to synthesize a variety of active compounds .

HY-N6880

Rabdosiin (+)-Rabdosiin	Structural Classification Classification of Application Fields Labiatae Lignans Phenylpropanoids Piliostigma thonningii (Schumach.) Milne-Redh. Plants Inflammation/Immunology Disease Research Fields	Drug Derivative
Rabdosiin ((+)-Rabdosiin) is a Caffeic acid (HY-N0172) tetramer. Rabdosiin can be isolated from Macrotomia euchroma .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Source Classification	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-N12445

Quercetin-3'-O-glucoside 1 Publications Verification	Malvaceae Structural Classification Flavonols Flavonoids Abelmoschus manihot (Linn.) Medicus Plants Source Classification	Topoisomerase Caspase Apoptosis SOD
Quercetin-3'-O-glucoside is an orally active flavonoid glycoside. Quercetin-3'-O-glucoside reduces liver glucose-6-phosphatase activity, alters serum insulin and glucose levels, and regulates the activities of antioxidant enzymes in the liver and kidney. Quercetin-3'-O-glucoside inhibits DNA topoisomerase II, induces S-phase cell cycle arrest and caspase-3-mediated apoptosis in hepatocellular carcinoma cells. Quercetin-3'-O-glucoside selectively inhibits EGFR-mediated signaling pathways targeting AKT, ERK1/2, FAK and MEK1/2. Quercetin-3'-O-glucoside inhibits growth factor-induced migration and invasion in pancreatic cancer cells. Quercetin-3'-O-glucoside exerts free radical scavenging effects. Quercetin-3'-O-glucoside is applicable to research related to pancreatic cancer, diabetes, hepatocellular carcinoma and malignant tumors .

HY-N8745

α-Peltatin	Podophyllum peltatum L. Lignans Phenylpropanoids Plants Berberidaceae Source Classification	Fungal
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-18258R

Berberine chloride (Standard) Natural Yellow 18 chloride (Standard)	Alkaloids Structural Classification Phellodendron amurense Rupr. Rutaceae Plants Isoquinoline Alkaloids Source Classification	Reference Standards Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields Source Classification	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), DNA methyltransferases (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits **DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis*. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA* synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-19825

Rebeccamycin	Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer Source Classification	Topoisomerase ADC Payload Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-W713570

Nectandrin B	Monophenols Saururaceae Saururus chinensis (Lour.) Baill. Phenols Plants Source Classification	Topoisomerase
Nectandrin B is an inhibitor of DNA topoisomerases I and II, which is found in Saururus chinensis. Nectandrin B is promising for research of cancers .

HY-B0398R

Nalidixic acid (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Topoisomerase
Nalidixic acid (Standard) is the analytical standard of Nalidixic acid. This product is intended for research and analytical applications. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-13062R

Daunorubicin hydrochloride (Standard) Daunomycin hydrochloride (Standard); RP 13057 hydrochloride (Standard); Rubidomycin hydrochloride (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Phenols Polyphenols Source Classification	Reference Standards Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-16560R

Camptothecin (Standard) Campathecin (Standard); (S)-(+)-Camptothecin (Standard); CPT (Standard)	Alkaloids Structural Classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants	Reference Standards Topoisomerase ADC Payload MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

HY-N15319

Eupolauridine Canangine	Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Source Classification	Topoisomerase Fungal
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC₅₀ values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases .

HY-N10367

Corydamine	Alkaloids Corydalis bulleyana Diels Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer Source Classification	Topoisomerase
Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity .

HY-N15597

Melicopidine NSC 34757	Alkaloids Other Alkaloids Rutaceae Medicosma subsessilis T.G.Hartley Plants Source Classification	Topoisomerase
Melicopidine (NSC 34757) is a **DNA topoisomerase** inhibitor, which is an acridone alkaloid found in the bark of Medicosma subsessilis. Melicopidine exerts potential antitumor activity by binding to DNA or inhibiting related enzyme activity .

HY-N0872R

Isosteviol (Standard) (-)-Isosteviol (Standard); iso-Steviol (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Interleukin Related Reference Standards Reactive Oxygen Species (ROS) Topoisomerase
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-167671

BE-10988	Quinones Structural Classification Microorganisms Benzene Quinones Source Classification	Topoisomerase
BE-10988 is a **DNA topoisomerase** inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes .

HY-N10115

Huanglongmycin N	Quinones Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Cancer Source Classification	Topoisomerase
Huanglongmycin N is a DNA topoisomerase I inhibitor (EC₅₀ = 14 μM).

HY-15552R

Podofilox (Standard) Podophyllotoxin (Standard)	Structural Classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Source Classification	Reference Standards Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-15753R

Ellipticine (Standard) NSC 71795 (Standard)	Apocynaceae Alkaloids Structural Classification Marine natural products Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Indole Alkaloids Source Classification	Topoisomerase Reference Standards
Ellipticine (Standard) is the analytical standard of Ellipticine. This product is intended for research and analytical applications. Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-15753AR

Ellipticine hydrochloride (Standard) NSC 71795 hydrochloride (Standard)	Apocynaceae Alkaloids Structural Classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Indole Alkaloids Source Classification	Topoisomerase Reference Standards
Ellipticine (hydrochloride) (Standard) is the analytical standard of Ellipticine (hydrochloride). This product is intended for research and analytical applications. Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

HY-17577R

Berberine chloride hydrate (Standard) Natural Yellow 18 chloride hydrate (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Source Classification	Reference Standards Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine (chloride hydrate) (Standard) is the analytical standard of Berberine (chloride hydrate). This product is intended for research and analytical applications. Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-N11536

erythro-Austrobailignan-6	Saururaceae Saururus chinensis (Lour.) Baill. Lignans Phenylpropanoids Plants Source Classification	Topoisomerase Apoptosis
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA *topoisomerase* I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

Cat. No.	Product Name	Chemical Structure

HY-13631AS

Exatecan-d5 mesylate
Exatecan-d₅ (DX8951f-d₅) mesylate is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research .

HY-13631DS

DXd-d5
DXd-d₅ is a deuterium labeled DXd. DXd is a potent DNA topoisomerase I inhibitor, with an IC₅₀ of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .

HY-13704S

SN-38-d3
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively .

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells .

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-13562AS

Banoxantrone-d12 dihydrochloride
Banoxantrone-d₁₂ (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-13562S

Banoxantrone-d12
Banoxantrone-d₁₂ is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-13631AS1

Exatecan-d3 mesylate
Exatecan-d₃ (DX8951f-d₃) mesylate is deuterium-labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC₅₀ of 0.975 μg/mL .

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-W744243

Etoposide-d4
Etoposide-d₄ (VP-16-d₄; VP-16-213-d₄) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II .

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-W700069

Gatifloxacin-d4

Gatifloxacin-d₄ (AM-1155-d₄) is the deuterium labeled Gatifloxacin (HY-10581). Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC₅₀ = 13.8 μg/mL for S. aureus topoisomerase IV) and E.coli DNA gyrase (IC₅₀ = 0.109 μg/mL) . Gatifloxacin can be used for the study of bacterial conjunctivitis in vivo.

HY-B0356S2

Ciprofloxacin-d4

Ciprofloxacin-d₄ (Bay-09867-d₄) is deuterium labeled Ciprofloxacin. Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .

HY-B0330DS

(R)-Ofloxacin-d3

(R)-Ofloxacin-d₃ is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B0147S1

Pefloxacin-d3

Pefloxacin-d₃ (Pefloxacinium-d₃) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0147S

Pefloxacin-d5

Pefloxacin-d₅ (Pefloxacinium-d₅) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0268S2

Enoxacin-d8 hydrate

Enoxacin-d₈ (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0330BS1

Levofloxacin-d3 hydrochloride

Levofloxacin-d₃ ((-)-Ofloxacin-d₃) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity .

HY-W744235

Levofloxacin-d3 sodium

Levofloxacin-d₃ sodium is the deuterium labeled Levofloxacin sodium (HY-B0330C). Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity .

HY-B0395DS

(1R,2S,7R)-Sitafloxacin-d4 hydrochloride
(1R,2S,7R)-Sitafloxacin-d₄ hydrochloride is deuterium labeled (1R,2S,7R)-Sitafloxacin hydrochloride (HY-B0395D). (R)-Sitafloxacin (DU-6857), a stereoisomer of Sitafloxacin (DU-6859a), is also an inhibitor of topoisomerases, with an IC₅₀ of 0.18 μg/mL of DNA gyrase .

HY-B0506S1

Nadifloxacin-d5

Nadifloxacin-d₅ (OPC7251-d₅) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

HY-N0095S

(S)-10-Hydroxycamptothecin-d5
(S)-10-Hydroxycamptothecin-d₅ (10-HCPT-d₅) is the deuterium labeled (S)-10-Hydroxycamptothecin. (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia research .

HY-42487S1

Exatecan Intermediate 1-d2
Exatecan Intermediate 1-d₂ is the deuterium labeled Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.

Targets Recommended: Topoisomerase DNA-PK DNA Glycosylase DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13631AG

Exatecan mesylate DX8951f	ADC Payload Topoisomerase	Cancer
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research .

HY-16700G

PNU-159682	ADC Payload Topoisomerase	Cancer
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-B0356G

Ciprofloxacin Bay-09867	Bacterial Topoisomerase Akt β-catenin	Inflammation/Immunology
Ciprofloxacin GMP is Ciprofloxacin (HY-B0356) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ciprofloxacin (Bay-09867) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin exerts bactericidal effects primarily by inhibiting *topoisomerase* II and IV. Ciprofloxacin inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity .

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