2. Apoptosis
  3. Apoptosis
  4. 2-Methoxycinnamaldehyde

2-Methoxycinnamaldehyde  (Synonyms: o-Methoxycinnamaldehyde)

Cat. No.: HY-W046353 Purity: ≥98.0%
COA Handling Instructions

2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration.

For research use only. We do not sell to patients.

2-Methoxycinnamaldehyde Chemical Structure

2-Methoxycinnamaldehyde Chemical Structure

CAS No. : 1504-74-1

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Based on 1 publication(s) in Google Scholar

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Description

2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity[1][2][3]. 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9[2]. 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration[3].

Molecular Weight

162.19

Appearance

Solid

Formula

C10H10O2
CAS No.
SMILES

O=C/C=C/C1=CC=CC=C1OC
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (616.56 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1656 mL 30.8280 mL 61.6561 mL
5 mM 1.2331 mL 6.1656 mL 12.3312 mL
10 mM 0.6166 mL 3.0828 mL 6.1656 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (15.41 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.95%

COA (248 KB) HNMR (122 KB) GC (213 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

2-Methoxycinnamaldehyde1504-74-1o-MethoxycinnamaldehydeApoptosisInhibitorinhibitorinhibit

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