N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan)

Cat. No.: HY-177683: Data Sheet Handling Instructions
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N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) is a drug-linker conjugate for ADC (Drug-Linker Conjugate for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and a DNA topoisomerase I inhibitor Exatecan (HY-13631), and an ADC linker composition. N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) can be used for synthesis of ADCs and for cancer research.

For research use only. We do not sell to patients.

N-(DBCO-PEG4)-N-(PEG4-Val-Cit-PAB-MMAE)-N-(PEG4-Val-Cit-PAB-Exatecan) Chemical Structure

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1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
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Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2976.47

Formula

C₁₅₃H₂₁₆FN₂₁O₃₈

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCC(N(CCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC4=CC=C(COC(N[C@H]5CCC6=C7C5=C8C(C(N9C8)=CC([C@](O)%10CC)=C(C9=O)COC%10=O)=NC7=CC(F)=C6C)=O)C=C4)=O)CCCNC(N)=O)=O)C(C)C)=O)CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC%11=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N%12[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C%13=CC=CC=C%13)=O)CCC%12)=O)C)=O)=O)=O)C=C%11)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (16.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3360 mL	1.6798 mL	3.3597 mL
5 mM	0.0672 mL	0.3360 mL	0.6719 mL
10 mM	0.0336 mL	0.1680 mL	0.3360 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.3360 mL	1.6798 mL	3.3597 mL	8.3992 mL
	5 mM	0.0672 mL	0.3360 mL	0.6719 mL	1.6798 mL
	10 mM	0.0336 mL	0.1680 mL	0.3360 mL	0.8399 mL
	15 mM	0.0224 mL	0.1120 mL	0.2240 mL	0.5599 mL