2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Topoisomerase ADC Cytotoxin
  4. Ac-Exatecan

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).

For research use only. We do not sell to patients.

Ac-Exatecan Chemical Structure

Ac-Exatecan Chemical Structure

CAS No. : 2922852-48-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Ac-Exatecan:

Ac-Exatecan Related Antibodies

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Description

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

Molecular Weight

477.48

Formula

C26H24FN3O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Ac-Exatecan Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Exatecan2922852-48-8TopoisomeraseADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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