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Cat. No.: HY-10982A

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Amonafide dihydrochloride

(Synonyms: AS1413 dihydrochloride)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR).

For research use only. We do not sell to patients.

CAS No.: 150091-68-2
Formula: C₁₆H₁₉Cl₂N₃O₂
Molecular Weight:356.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Amonafide dihydrochloride Chemical Structure

CAS No.: 150091-68-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Topoisomerase Isoforms :

Chemical Information

CAS No. 150091-68-2
Molecular Weight 356.25
Formula C₁₆H₁₉Cl₂N₃O₂
SMILES

O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C.Cl.Cl
Synonyms

AS1413 dihydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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ACS Appl Mater Interfaces

Drastic Modulation of Molecular Packing and Intrinsic Dissolution Rates by Meniscus-Guided Coating of Extremely Confined Pharmaceutical Thin Films. [Abstract]

2021 Dec 1;13(47):56519-56529. PMID: 34783517
Anal Chem

Metal-Enhanced Aggregation-Induced Emission Strategy for the HIV-I RNA-Binding Ligand Assay. [Abstract]

2022 Mar 22;94(11):4695-4702. PMID: 35258935
J Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension. [Abstract]

2026 May 19;15(10):e045580. PMID: 42132175
PLoS One

Drug repositioning for pan-cancers of the digestive system: Identification of amonafide and BX795 as potential therapeutics via integrative Omics analysis. [Abstract]

2025 Jun 16;20(6):e0325700. PMID: 40522954
Cancer Manag Res

UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway. [Abstract]

2019 Mar 22:11:2339-2348. PMID: 30962721

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Amonafide: a potential role in treating acute myeloid leukemia

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Amonafide dihydrochloride

5 Cited Publications

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Biological Activity
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Publications (5)
Purity & Documentation
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Amonafide dihydrochloride

Publications Citing Use of MedChemExpress (MCE) Amonafide dihydrochloride

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

Amonafide dihydrochloride Related Classifications

HY-10982A Related Classifications