150091-68-2
Chemical Structure
Amonafide dihydrochloride
Synonym(s): AS1413 dihydrochloride
- CAS No.: 150091-68-2
- Formula:C16H19Cl2N3O2
- Molecular Weight:356.25
IUPAC Name: 5-amino-2-(2-(dimethylamino)ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione dihydrochloride
InChIKey: AEMLYYQEBPJIEO-UHFFFAOYSA-N
SMILES: O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C.Cl.Cl
Biological Activity: Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR)[1].
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Amonafide dihydrochloride | Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR). | |||||||||||||||||||||
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Keywords
