country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-162101

Copy Link Print Information

Topoisomerase inhibitor 3

Topoisomerase inhibitor 3 (compound 9) is a potent Topoisomerase inhibitor. Topoisomerase inhibitor 3 shows antiproliferative and anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 3026832-96-9
Formula: C₂₂H₂₀N₂O₅
Molecular Weight:392.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Topoisomerase inhibitor 3 Chemical Structure

CAS No.: 3026832-96-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Topoisomerase inhibitor 3 (compound 9) is a potent Topoisomerase inhibitor. Topoisomerase inhibitor 3 shows antiproliferative and anti-tumor activity^[1].

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CAPAN-1	IC₅₀	1 μM Compound: 9	Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
HCT-116	IC₅₀	1.9 μM Compound: 9	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
HL-60	IC₅₀	2.1 μM Compound: 9	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
K562	IC₅₀	1.9 μM Compound: 9	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
LN-229	IC₅₀	0.7 μM Compound: 9	Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
NCI-H1975	IC₅₀	2.3 μM Compound: 9	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]
Z-138	IC₅₀	2.5 μM Compound: 9	Antiproliferative activity against human Z138 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human Z138 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38176358]

Chemical Information

CAS No. 3026832-96-9
Molecular Weight 392.40
Formula C₂₂H₂₀N₂O₅
SMILES

O=C1C2=C(C(O)=C(CC(C(N3C[C@@H](N)CC3)=O)C4)C4=C2O)C(C5=C1C=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tikhomirov AS, et al. Synthesis and antitumor activity of cyclopentane-fused anthraquinone derivatives. Eur J Med Chem. 2024 Feb 5;265:116103. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Topoisomerase inhibitor 3

All Topoisomerase Isoforms