Amsacrine (gluconate)
Based on 8 publication(s) in Google Scholar
Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 80277-07-2
- Formula: C27H31N3O10S
- Molecular Weight:589.61
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Amsacrine (gluconate)
More- Cell Metab. 2022 Mar 1;34(3):424-440.e7. [Abstract]
- J Adv Res. 2024 Apr:58:117-128. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Nucleic Acid Ther. 2023 Aug;33(4):248-264. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- University of Colorado Denver. 2024.
- bioRxiv. September 29, 2021.
All Topoisomerase Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 80277-07-2
-
Molecular Weight 589.61
-
Formula C27H31N3O10S
-
SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.COC(C=C(C=C1)NS(C)(=O)=O)=C1NC2=C(C=CC=C3)C3=NC4=C2C=CC=C4
-
Synonyms
m-AMSA (gluconate); Acridinyl anisidide (gluconate)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
-
Journal Impact Factor
-
Most Recent
-
Cell Metab
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. [Abstract]2022 Mar 1;34(3):424-440.e7. PMID: 35150639 -
J Adv Res
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages. [Abstract]2024 Apr:58:117-128. PMID: 37290606 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Nucleic Acid Ther
Mammalian Target of Rapamycin Inhibition Enhances Delivery and Activity of Antisense Oligonucleotides in Uveal Melanoma Cells. [Abstract]2023 Aug;33(4):248-264. PMID: 37389884 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
-
Purity & Documentation
References
[1]. Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94. [Content Brief]
[2]. Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33(6):426-33. [Content Brief]
[3]. Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68(7-8):989-97. [Content Brief]
[4]. Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2016 Oct 19 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amsacrine (gluconate) Related Classifications
HY-13551B Related Classifications
Powered by Bioz