Apoptosis inducer 54
Apoptosis inducer 54 is an apoptosis inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer.
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- Formule: C29H30N6O6
- Masse moléculaire:558.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
In Vitro
Apoptosis inducer 54 (compound 9f) shows potent antiproliferative effects, with IC50 values of 16.1 μM and 19.7 μM against A549 and SW480, respectively. Apoptosis inducer 54 shows significant selectivity towards A549 and SW480 cancer cells compared to the normal MRC-5[1].
Apoptosis inducer 54 (16.1 μM; 24-48 h; A549) induces early and late apoptosis in a time-dependent manner[1].
Apoptosis inducer 54 (16.1 μM; 24-48 h; A549) shows cell cycle arrest at the S phase in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:16.1 μM
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Incubation Time:24 h, 48 h
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Result:Significantly induced early and late apoptosis in A549 cells after 48 h.
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Cell Line:A549
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Concentration:16.1 μM
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Incubation Time:24 h, 48 h
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Result:Showed a significant increase in the number of cells in the S phase, along with a significant reduction in the number of cells in the G0/G1 phase, and a non-significant decrease in the G2/M phase.
Chemical Information
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Masse moléculaire 558.59
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Formule C29H30N6O6
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SMILES
O=C(NC1=CC=C(OC)C=C1OC)CN2N=NC(CN3C(C4=CC(OC)=C(OC)C(OC)=C4)=NC5=CC=CC=C35)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 54 Related Classifications
HY-179152 Related Classifications
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