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Cat. No.: HY-146437

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Topoisomerase I inhibitor 6

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2393082-56-7
Formula: C₂₃H₂₁N₇O
Molecular Weight:411.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Topoisomerase I inhibitor 6 Chemical Structure

CAS No.: 2393082-56-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>10 μM Compound: 3	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay	[PMID: 32682183]
MCF7	IC₅₀	2.5 μM Compound: 3	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay	[PMID: 32682183]

Chemical Information

CAS No. 2393082-56-7
Molecular Weight 411.46
Formula C₂₃H₂₁N₇O
SMILES

NC1=CC=C(C=C1)C2=CC=C3N=CC(C4=NN=CO4)=C(C3=C2)NCCCN5C=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kundu B, et al. Development of a metabolically stable topoisomerase I poison as anticancer agent. Eur J Med Chem. 2020 Sep 15;202:112551. doi: 10.1016/j.ejmech.2020.112551. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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