DBCO-PEG3-GGFG-Exatecan
Based on 1 Customer Validation
DBCO-PEG3-GGFG-Exatecan is a Drug-linker conjugate for ADC. DBCO-PEG3-GGFG-Exatecan contains the ADC linker (DBCO-PEG3-GGFG) and a DNA topoisomerase I inhibitor Exatecan (HY-13631).
For research use only. We do not sell to patients.
- Purity: 95.65%
- CAS No.: 2754384-71-7
- Formula: C67H70FN9O14
- Molecular Weight:1244.32
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Topoisomerase I |
DCBPR2002-4 (DBCO-PEG3-GGFG-Exatecan construct) (72 h) can inhibit the viability of OVCAR-3 ovarian cancer cells expressing mesothelin in vitro, with its IC50 being 130.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2754384-71-7
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Appearance Solid
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Molecular Weight 1244.32
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Formula C67H70FN9O14
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Color White to light yellow
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SMILES
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (40.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.8037 mL | 4.0183 mL | 8.0365 mL | 20.0913 mL |
| 5 mM | 0.1607 mL | 0.8037 mL | 1.6073 mL | 4.0183 mL | |
| 10 mM | 0.0804 mL | 0.4018 mL | 0.8037 mL | 2.0091 mL | |
| 15 mM | 0.0536 mL | 0.2679 mL | 0.5358 mL | 1.3394 mL | |
| 20 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0046 mL | |
| 25 mM | 0.0321 mL | 0.1607 mL | 0.3215 mL | 0.8037 mL | |
| 30 mM | 0.0268 mL | 0.1339 mL | 0.2679 mL | 0.6697 mL | |
| 40 mM | 0.0201 mL | 0.1005 mL | 0.2009 mL | 0.5023 mL |
DBCO-PEG3-GGFG-Exatecan Related Classifications
HY-177546 Related Classifications
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