Deruxtecan-Eribulin
Based on 1 Customer Validation
Deruxtecan-Eribulin is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule Exatecan (HY-13631) (DNA topoisomerase I inhibitor) and Eribulin (HY-13442) (Microtubule inhibitor). Deruxtecan-Eribulin can be used for ADC synthesis.
For research use only. We do not sell to patients.
- Purity : 95.83%
- Formula: C122H151FN16O32
- Molecular Weight:2372.59
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
IC50 & Target
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Dual payloads |
In Vitro
Deruxtecan-Eribulin consists of two distinct toxins conjugated via a cleavable linker: Deruxtecan induces apoptosis in cancer cells by interfering with DNA replication, while Eribulin—a tubulin inhibitor—halts cell division by obstructing microtubule polymerization, thereby killing the cancer cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 2372.59
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Formula C122H151FN16O32
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Color Off-white to light yellow
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SMILES
C=C1C[C@@]2([H])O[C@@]1([H])CC[C@]3([H])O[C@](C([C@H](C)C3)=C)([H])C[C@@]4([H])[C@]([C@@H](OC)[C@@H](C[C@H](O)CNC(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COC6=CC=C(CC(NC(CCCCCN7C(C=CC7=O)=O)=O)C(NCC(NCC(N[C@@H](CC8=CC=CC=C8)C(NCC(NCOCC(N[C@@H]9C%10=C%11C(C(N%12C%11)=CC([C@](O)(C(OC%13)=O)CC)=C%13C%12=O)=NC%14=CC(F)=C(C)C(CC9)=C%14%10)=O)=O)=O)=O)=O)=O)C=C6)=O)=O)=O)C=C5)=O)O4)([H])CC(C[C@]%15([H])O[C@]%16([H])[C@]%17([H])O[C@@]%18(O[C@@]%19([H])[C@@](O[C@]%17([H])[C@@]%19([H])O[C@@]%16([H])CC%15)([H])C%18)CC2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 60 mg/mL (25.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4215 mL | 2.1074 mL | 4.2148 mL | 10.5370 mL |
| 5 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1074 mL | |
| 10 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL | |
| 15 mM | 0.0281 mL | 0.1405 mL | 0.2810 mL | 0.7025 mL | |
| 20 mM | 0.0211 mL | 0.1054 mL | 0.2107 mL | 0.5269 mL | |
| 25 mM | 0.0169 mL | 0.0843 mL | 0.1686 mL | 0.4215 mL |
Deruxtecan-Eribulin Related Classifications
HY-164836 Related Classifications
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