2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Ethonafide

Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β.

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Ethonafide

Ethonafide Chemical Structure

CAS No. : 160554-87-0

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Ethonafide Related Antibodies

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Description

Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
2.9 nM
Compound: 24
Tested against A549 lung carcinoma in the sulforhodamine B assay.
Tested against A549 lung carcinoma in the sulforhodamine B assay.
[PMID: 8648600]
L1210 IC50
6.7 nM
Compound: 24
Inhibitory activity against resistant murine leukemia L1210 cell lines.
Inhibitory activity against resistant murine leukemia L1210 cell lines.
[PMID: 8648600]
L1210 IC50
8 nM
Compound: 24
Inhibitory activity against sensitive L1210 cell lines
Inhibitory activity against sensitive L1210 cell lines
[PMID: 8648600]
L1210 IC50
9.3 nM
Compound: 24
An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
An average for IC50 values in the two solid tumor cell lines and sensitive L1210 leukemia cell line.
[PMID: 8648600]
MCF7 IC50
11 nM
Compound: 24
Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
[PMID: 8648600]
MCF7 IC50
14 nM
Compound: 24
Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (mitoxantrone resistant)cell line in the sulforhodamine B assay.
[PMID: 8648600]
MCF7 IC50
18 nM
Compound: 24
Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
Tested against MXF7 breast carcinoma (doxorubicin resistant) cell line in the sulforhodamine B assay.
[PMID: 8648600]
OVCAR-3 IC50
0.8 nM
Compound: 24
Inhibitory activity against OVCAR-3 cell line
Inhibitory activity against OVCAR-3 cell line
[PMID: 8648600]
UACC-375 IC50
19 nM
Compound: 24
Inhibitory activity against AUC375 cell line
Inhibitory activity against AUC375 cell line
[PMID: 8648600]
WiDr IC50
17 nM
Compound: 24
Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
Tested against WiDr colon (sensitive) in the sulforhodamine B assay.
[PMID: 8648600]
WiDr IC50
63 nM
Compound: 24
Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
Tested against WiDr colon carcinoma (resistant) in the sulforhodamine B assay.
[PMID: 8648600]
Molecular Weight

362.42

Formula

C22H22N2O3
CAS No.
SMILES

O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ethonafide Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethonafide160554-87-0AMP-53 6-EthoxyazonafideAMP53AMP 53Topoisomerasetopoisomerase IIαtopoisomerase βprostate cancerInhibitorinhibitorinhibit

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