Cholesterol hemisuccinate Tris salt  (Synonyms: Cholesterol hydrogen succinate Tris salt; CHS-Tris)

Cholesterol hemisuccinate Tris salt (CHS-Tris) is an ionizable anionic detergent that stabilizes large unilamellar vesicles. CHS-Tris and Lauryl Maltose Neopentyl Glycol (LMNG) or n-Dodecyl-β-D-Maltoside (DDM) are used together for the solubilization of membrane proteins while maintaining structural integrity and activity. Cholesteryl succinate also reportedly exhibits antiproliferative activity.

607.86

C₃₅H₆₁NO₇

102601-49-0

OCC(CO)(N)CO.C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83.  [Content Brief]

  [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.  [Content Brief]