1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Edotecarin

Edotecarin (Synonyms: J 107088; PF 804950)

Cat. No.: HY-13618
Handling Instructions

Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.

For research use only. We do not sell to patients.

Edotecarin Chemical Structure

Edotecarin Chemical Structure

CAS No. : 174402-32-5

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Description

Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.

IC50 & Target[1]

Topoisomerase I

50 nM (IC50)

Protein Kinase C

160 μM (IC50)

In Vitro

In the presence of human colon cancer cells labeled with 3Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

608.55

Formula

C₂₉H₂₈N₄O₁₁

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Edotecarin
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