Synthesis and biological activities of NB-506 analogues modified at the glucose group

  • Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22. doi: 10.1016/s0960-894x(00)00004-4.
M Ohkubo  1 ,  T Nishimura ,  H Kawamoto ,  M Nakano ,  T Honma ,  T Yoshinari ,  H Arakawa ,  H Suda ,  H Morishima ,  S Nishimura
Affiliations
  • 1. Banyu Tsukuba Research Institute, Ibaraki, Japan.
PMID: 10743939 DOI: 10.1016/s0960-894x(00)00004-4
Abstract

A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent Anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting Topoisomerase I.