174402-32-5
Chemical Structure
Edotecarin
Synonym(s): J 107088; PF 804950
- CAS No.: 174402-32-5
- Formula:C29H28N4O11
- Molecular Weight:608.55
IUPAC Name: 6-((1,3-dihydroxypropan-2-yl)amino)-2,10-dihydroxy-12-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
InChIKey: QMVPQBFHUJZJCS-NTKFZFFISA-N
SMILES: O=C1N(NC(CO)CO)C(C2=C1C3=C(C4=C2C5=C(N4[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)C=C(O)C=C5)NC7=C3C=CC(O)=C7)=O
Biological Activity: Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.
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Edotecarin | Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM. | |||||||||||||||||||||
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Keywords
