Topoisomerase I inhibitor 16

製品番号: HY-161385: Data Sheet 取扱説明書
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Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI₅₀ 39 nM.

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Topoisomerase I inhibitor 16 構造式

CAS 番号 : 3036181-84-4

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MOQ		Minimum order quantity
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Topoisomerase Topo I Topo II DNA gyrase

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純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target

Topoisomerase I

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	49 nM Compound: 3e	Growth inhibition of human A549 cells assessed as reduction in cell viability Growth inhibition of human A549 cells assessed as reduction in cell viability	[PMID: 38518997]
ACHN	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human ACHN cells assessed as reduction in cell viability Growth inhibition of human ACHN cells assessed as reduction in cell viability	[PMID: 38518997]
DU-145	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human DU-145 cells assessed as reduction in cell viability Growth inhibition of human DU-145 cells assessed as reduction in cell viability	[PMID: 38518997]
HCT-116	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human HCT-116 cells assessed as reduction in cell viability Growth inhibition of human HCT-116 cells assessed as reduction in cell viability	[PMID: 38518997]
LOX IMVI	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human LOX IMVI cells assessed as reduction in cell viability Growth inhibition of human LOX IMVI cells assessed as reduction in cell viability	[PMID: 38518997]
MCF7	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human MCF7 cells assessed as reduction in cell viability Growth inhibition of human MCF7 cells assessed as reduction in cell viability	[PMID: 38518997]
MKN-28	GI₅₀	19 nM Compound: 3e	Growth inhibition of human MKN-28 cells assessed as reduction in cell viability Growth inhibition of human MKN-28 cells assessed as reduction in cell viability	[PMID: 38518997]
SK-OV-3	GI₅₀	18 nM Compound: 3e	Growth inhibition of human SK-OV-3 cells assessed as reduction in cell viability Growth inhibition of human SK-OV-3 cells assessed as reduction in cell viability	[PMID: 38518997]
U-251	GI₅₀	< 10 nM Compound: 3e	Growth inhibition of human U-251 cells assessed as reduction in cell viability Growth inhibition of human U-251 cells assessed as reduction in cell viability	[PMID: 38518997]

体外実験

Topoisomerase I inhibitor 21 inhibits proliferations of cancer cells MCF7, U251, HCT-166, A549, LOX-IMVI, SK-OV-3, ACHN, MKN28 and DU145, with EC₅₀s <50 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

457.52

分子式

C₂₇H₂₇N₃O₄

CAS 番号

3036181-84-4

SMILES

OC1=CC2=C(C=C1)C3=C(C(N=CC4=C5C=C(OC)C(O)=C4)=C5N3CCCN6CCOCC6)C=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sakai K, et al., Design, synthesis, and biological evaluation of novel benzo[6,7]indolo[3,4-c]isoquinolines as anticancer agents with topoisomerase I inhibition. Bioorg Med Chem Lett. 2024 Mar 20:129710. [Content Brief]