3036181-84-4
Chemical Structure
Topoisomerase I inhibitor 16
- CAS No.: 3036181-84-4
- Formula:C27H27N3O4
- Molecular Weight:457.52
InChIKey: CQRSROCIVAXIEA-UHFFFAOYSA-N
SMILES: OC1=CC2=C(C=C1)C3=C(C(N=CC4=C5C=C(OC)C(O)=C4)=C5N3CCCN6CCOCC6)C=C2
Biological Activity: Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM[1].
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Topoisomerase I inhibitor 16 | Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM. | |||||||||||||||||||||
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