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Cat. No.: HY-106307

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Retelliptine

Name: Retelliptine
Brand: MedChemExpress
SKU: HY-106307
Availability: PreOrder

(Synonyms: BD84)

Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of Topoisomerase II with anticancer activity. Retelliptine can bind to DNA and inhibit Topoisomerase II during DNA replication.

For research use only. We do not sell to patients.

CAS No.: 72238-02-9
Formula: C₂₅H₃₂N₄O
Molecular Weight:404.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Retelliptine Chemical Structure

CAS No.: 72238-02-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Topoisomerase Isoforms :

Chemical Information

CAS No. 72238-02-9
Molecular Weight 404.55
Formula C₂₅H₃₂N₄O
SMILES

CCN(CC)CCCNC1=NC=CC2=C(C)C3=C(C4=CC(OC)=CC=C4N3)C(C)=C21
Synonyms

BD84
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

PCNA Immunodetection Proliferation Assay
PCNA immunodetection measures proliferative activity by detecting proliferating cell nuclear antigen, a nuclear protein associated with DNA polymerase δ function and DNA replication. The assay readout is the proportion of PCNA-positive nuclei among total counted cells, but PCNA labeling is not identical to BrdU labeling because PCNA can mark late G1/early S-associated replication competence and may persist beyond active DNA synthesis depending on fixation and extraction conditions.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kattan J, et al. Phase I study of retelliptine dihydrochloride (SR 95325 B) using a single two-hour intravenous infusion schedule[J]. American journal of clinical oncology, 1994, 17(3): 242-245. [Content Brief]

[2]. Maulard C, et al. Binding of retelliptine, a new antitumoral agent, to serum proteins and erythrocytes[J]. Biochemical pharmacology, 1990, 40(4): 895-898. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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