72238-02-9
72238-02-9
Chemical Structure
Retelliptine
Synonym(s): BD84
- CAS. Nr.: 72238-02-9
- Formula:C25H32N4O
- Molecular Weight:404.55
IUPAC Name: N1,N1-diethyl-N3-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)propane-1,3-diamine
InChIKey: PAVKBQLPQCDVNI-UHFFFAOYSA-N
SMILES: CCN(CC)CCCNC1=NC=CC2=C(C)C3=C(C4=CC(OC)=CC=C4N3)C(C)=C21
Biological Activity: Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of Topoisomerase II with anticancer activity. Retelliptine can bind to DNA and inhibit Topoisomerase II during DNA replication[1][2].
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Retelliptine | Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of Topoisomerase II with anticancer activity. Retelliptine can bind to DNA and inhibit Topoisomerase II during DNA replication. | |||||||||||||||||||||
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References
- [1]. Kattan J, et al. Phase I study of retelliptine dihydrochloride (SR 95325 B) using a single two-hour intravenous infusion schedule[J]. American journal of clinical oncology, 1994, 17(3): 242-245. [Content Brief]
- [2]. Maulard C, et al. Binding of retelliptine, a new antitumoral agent, to serum proteins and erythrocytes[J]. Biochemical pharmacology, 1990, 40(4): 895-898. [Content Brief]
