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Exatecan hydrochloride

(Synonyms: DX-8951 hydrochloride)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Exatecan (DX-8951) hydrochloride is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

For research use only. We do not sell to patients.

  • CAS No.: 144008-87-7
  • Formula: C24H23ClFN3O4
  • Molecular Weight:471.91
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Exatecan hydrochloride Chemical Structure
    Exatecan hydrochloride Chemical Structure
  • Experimental Validation Results for Exatecan hydrochloride
  • Experimental Validation Results for Exatecan hydrochloride
  • Experimental Validation Results for Exatecan hydrochloride
  • Experimental Validation Results for Exatecan hydrochloride
  • Experimental Validation Results for Exatecan hydrochloride
CAS No.: 144008-87-7
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Other Forms of Exatecan hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

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Publications Citing Use of MedChemExpress (MCE) Exatecan hydrochloride

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In Vivo Efficacy StudyCell Proliferation/Viability AssayHistological Imaging/StainingPK/PD AnalysisCell Imaging/Staining
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • Histological Imaging/Staining
  • PK/PD Analysis
  • Cell Imaging/Staining

All ADC Payloads Isoforms

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All Topoisomerase Isoforms

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  • Exatecan hydrochloride Chemical Structure
    Exatecan hydrochloride Chemical Structure
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    Exatecan hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. [Abstract]

    Customer Validation
     In vivo efficacy of AMT-562, Ab562-T1000-Exatecan (10 mg/kg; i.v.), and P-GGFG-DXd in PC9 xenograft model.

  • 1/16

    Exatecan hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. [Abstract]

    Customer Validation
     In vitro cytotoxicity of Exatecan and DXd in HER3-expressing cells. Cells were incubated with a concentration series of Exatecan or DXd for 5 days. Cell viability was measured by CCK-8 and IC50 for each cell line was calculated from cell viability-concentration plot.

  • 1/16

    Exatecan hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. [Abstract]

    Customer Validation
     Representative hematoxylin and eosin staining of toxicity organs of AMT-562 and Ab562-T1000-Exatecan (ADC; 30 mg/kg; i.v.). Scale bar, 200 mm.

  • 1/16

    Exatecan hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. [Abstract]

    Customer Validation
     Single dose pharmacokinetic profiles of AMT-562 (ADC) and Ab562-GGFG-DXd in mice. ADCs were intravenously administered to mice at the dose of 10 mg/kg.

  • 1/16

    Exatecan hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027. [Abstract]

    Customer Validation
     Patient-derived colon cancer organoids response to AMT-562 (ADC) and P-GGFG-DXd. Representative images of brightfield (left) and live/dead cells (right) for CO117 was shown. Colon cancer PDOs were treated with AMT-562 or P-GGFG-DXd at a serial concentration for 6 days. Live cells were stained by Calcein AM (green) and dead cells by PI (red).

  • Exatecan hydrochloride