Exatecan Intermediate 7

Cat. No.: HY-45157 Purity: 99.24%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).

For research use only. We do not sell to patients.

Exatecan Intermediate 7 Chemical Structure

CAS No. : 182182-32-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 220	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 220	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

264.25

Formula

C₁₃H₁₃FN₂O₃

CAS No.

182182-32-7

Appearance

Solid

Color

Light green to green

SMILES

CC(NC(C=C(F)C(C)=C1CC/C2=N\O)=C1C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (378.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7843 mL	18.9215 mL	37.8429 mL
5 mM	0.7569 mL	3.7843 mL	7.5686 mL
10 mM	0.3784 mL	1.8921 mL	3.7843 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.24%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) RP-HPLC (222 KB)

Handling Instructions (2659 KB)

References

[1]. Kamihara, et al. Aminotetralone derivatives and process for producing the same. World Intellectual Property Organization, WO9626181 A1 1996-08-29.

[2]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7843 mL	18.9215 mL	37.8430 mL	94.6074 mL
	5 mM	0.7569 mL	3.7843 mL	7.5686 mL	18.9215 mL
	10 mM	0.3784 mL	1.8921 mL	3.7843 mL	9.4607 mL
	15 mM	0.2523 mL	1.2614 mL	2.5229 mL	6.3072 mL
	20 mM	0.1892 mL	0.9461 mL	1.8921 mL	4.7304 mL
	25 mM	0.1514 mL	0.7569 mL	1.5137 mL	3.7843 mL
	30 mM	0.1261 mL	0.6307 mL	1.2614 mL	3.1536 mL
	40 mM	0.0946 mL	0.4730 mL	0.9461 mL	2.3652 mL
	50 mM	0.0757 mL	0.3784 mL	0.7569 mL	1.8921 mL
	60 mM	0.0631 mL	0.3154 mL	0.6307 mL	1.5768 mL
	80 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1826 mL
	100 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9461 mL