2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan 

Art. -Nr.: HY-148668A Reinheit: 98.99%
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MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM).

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MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan Chemische Struktur

CAS. Nr. : 2414254-52-5

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Other Forms of MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan:

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan Related Antibodies

Top Publications Citing Use of Products

Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Alle Topoisomerase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Topoisomerase Topo I Topo II DNA gyrase

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Beschreibung

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a agent-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1].

IC50 & Target[1]

Camptothecins

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan Related Antibodies
Molekulargewicht

1074.12

Formel

C55H60FN9O13
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@@H](C3CC3)C(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation
Verweise
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MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan2414254-52-5Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan
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