1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

Podophyllotoxin (Synonyms: Podofilox; PPT)

Cat. No.: HY-15552 Purity: 98.16%
Data Sheet SDS Handling Instructions

Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

For research use only. We do not sell to patients.
Podophyllotoxin Chemical Structure

Podophyllotoxin Chemical Structure

CAS No. : 518-28-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
100 mg $50 In-stock
500 mg $70 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Podophyllotoxin is a potent inhibitor of microtubule assembly and DNA topoisomerase II. IC50 Value: Target: Topoisomerase II; Microtubule/Tubulin Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00126113 VA Office of Research and Development Hearing Impairment August 2005
NCT02449356 Wangyuan Zou|Central South University Mechanical Ventilation Complication September 2015
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References
Molecular Weight

414.41

Formula

C₂₂H₂₂O₈

CAS No.

518-28-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Podophyllotoxin
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