Podofilox (Synonyms: Podophyllotoxin)

Name: Podofilox
Brand: MedChemExpress
SKU: HY-15552
Rating: 5.0 (6 reviews)

Cat. No.: HY-15552 Purity: 99.92%: Data Sheet
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Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

For research use only. We do not sell to patients.

CAS No. : 518-28-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

Other Forms of Podofilox:

Podofilox-d₆ Get quote
Podofilox (Standard) Get quote

6 Publications Citing Use of MCE Podofilox

Cell Proliferation/Viability Assay

Flow Cytometry

Cell Imaging/Staining

: Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203.; Cell viability was assessed in AGS and HGC-27 cells following incubation with Podofilox (0-80 nM) for 48 h.

: Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203.; The cell cycle was analyzed in AGS and HGC-27 cells following incubation with vehicle or 3.4 nM Podofilox for 48 h.

: Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203.; AGS and HGC-27 cells were incubated with vehicle or 3.4 nM Podofilox for 7 days, and cell colony formation was assessed.

: Podofilox purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2021 Nov;22(5):1203.; Western blot analysis of dysregulated genes following treatment with Podofilox.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

IC₅₀ & Target

Topoisomerase II; Microtubule/Tubulin

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	IC₅₀	0.003 μM Compound: podophyllotoxin	Cytotoxicity against human 1A9 cells Cytotoxicity against human 1A9 cells	[PMID: 18314944]
786-0	GI₅₀	16.9 nM Compound: PT, NSC 24818	Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human 786-0 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A-375	IC₅₀	2.62 μM Compound: 1	Anticancer activity against human A375 cells after 48 hrs by MTT assay Anticancer activity against human A375 cells after 48 hrs by MTT assay	[PMID: 22136907]
A-431	ED₅₀	0.03 μg/mL Compound: 12	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8277312]
A-431	ED₅₀	1.1 x 10^-6 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A431 cells by MTT assay Cytotoxicity against human A431 cells by MTT assay	[PMID: 7714533]
A-431	IC₅₀	> 100 μM Compound: PDT	Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A2780	IC₅₀	15 nM Compound: Podophyllotoxin	Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A2780	IC₅₀	15 nM Compound: Podophyllotoxin	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
A2780	IC₅₀	18 nM Compound: 1	Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27518758]
A2780	IC₅₀	20 nM Compound: Podophyllotoxin	Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A2780AD cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A498	ED₅₀	3.4 x 10^-7 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A498 cells by MTT assay Cytotoxicity against human A498 cells by MTT assay	[PMID: 7714533]
A498	GI₅₀	0.08 μM Compound: 1	In vitro cytotoxic activity against renal (A 498) cancer cell line. In vitro cytotoxic activity against renal (A 498) cancer cell line.	[PMID: 10465531]
A498	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human A498 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A498	IC₅₀	0.034 μg/mL Compound: Podophyllotoxin	Anticancer activity against human A498 cells after 24 hrs by MTT assay Anticancer activity against human A498 cells after 24 hrs by MTT assay	[PMID: 25305717]
A549	EC₅₀	16.5 nM Compound: PT	Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry Cell cycle arrest in human A549 cells assessed as accumulation of cells in G2/M phase after 24 hrs by propidium iodide staining-based flow cytometry	[PMID: 21916509]
A549	ED₅₀	7.7 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 7714533]
A549	GI₅₀	0.012 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 20067289]
A549	GI₅₀	12 nM Compound: 1a	Growth inhibition of human A549 cells after 72 hrs by SRB assay Growth inhibition of human A549 cells after 72 hrs by SRB assay	[PMID: 22607205]
A549	GI₅₀	13.8 nM Compound: PT, NSC 24818	Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human A549 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
A549	IC₅₀	0.0043 μg/mL Compound: 2	Growth inhibition of A549 (human lung carcinoma) cell line. Growth inhibition of A549 (human lung carcinoma) cell line.	[PMID: 2002477]
A549	IC₅₀	0.012 μM Compound: 1	In vitro cytotoxicity against A-549 (human lung carcinoma) cell line. In vitro cytotoxicity against A-549 (human lung carcinoma) cell line.	[PMID: 14971901]
A549	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against human A549 cells after 4 days Cytotoxicity against human A549 cells after 4 days	[PMID: 17197187]
A549	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 7673931]
A549	IC₅₀	0.012 μM Compound: 1 (Podophyllotoxin)	Antineoplastic activity against A-549 (human lung carcinoma) cell line. Antineoplastic activity against A-549 (human lung carcinoma) cell line.	10.1016/0960-894X(95)00432-S
A549	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
A549	IC₅₀	0.05 μM Compound: 6 (Podophyllotoxin)	Compound was tested for inhibition of cell growth of A-549 cells Compound was tested for inhibition of cell growth of A-549 cells	10.1016/0960-894X(95)00008-H
A549	IC₅₀	0.059 μM Compound: 2	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 25084144]
A549	IC₅₀	0.059 μM Compound: PPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 28131777]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28648953]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
A549	IC₅₀	0.09 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
A549	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human A549 cells after 24 hrs by MTS assay Cytotoxicity against human A549 cells after 24 hrs by MTS assay	[PMID: 19880222]
A549	IC₅₀	1.36 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells after 36 hrs by MTT assay Cytotoxicity against human A549 cells after 36 hrs by MTT assay	[PMID: 27262599]
A549	IC₅₀	105 nM Compound: PPT	Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	12 nM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
A549	IC₅₀	128.61 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 26292628]
A549	IC₅₀	13.62 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22687745]
A549	IC₅₀	13.62 μM Compound: Podophyllotoxing	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25462233]
A549	IC₅₀	15 nM Compound: 1	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 27518758]
A549	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	16 nM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
A549	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	2.55 μM Compound: 1	Cytotoxicity against human A549 cells assessed as cell viability by SRB assay Cytotoxicity against human A549 cells assessed as cell viability by SRB assay	[PMID: 26022842]
A549	IC₅₀	2.6 μM Compound: PTOX	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
A549	IC₅₀	2.6 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38107170]
A549	IC₅₀	2900 nM Compound: 2d	In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line	[PMID: 14980682]
A549	IC₅₀	291 nM Compound: PPT	Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against hypoxia-induced human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 31546197]
A549	IC₅₀	3.09 μM Compound: 1	Anticancer activity against human A549 cells after 48 hrs by MTT assay Anticancer activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24721832]
A549	IC₅₀	3.6 μM Compound: 1, Podo	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 23182091]
A549	IC₅₀	3.75 μM Compound: 1	Anticancer activity against human A549 cells after 48 hrs by MTT assay Anticancer activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22136907]
A549	IC₅₀	3.76 μM Compound: IV	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 29289881]
A549	IC₅₀	338 nM Compound: PPT	Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against taxol-resistant human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
A549	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
A549	IC₅₀	4.6 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 29289884]
A549	IC₅₀	5.37 nM Compound: PPT	Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
A549	IC₅₀	5.61 μM Compound: PDT	Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
A549	IC₅₀	7.34 μM Compound: Podophyllotoxin	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
A549	IC₅₀	7.38 μM Compound: 1, VP-16	Cytotoxicity against human A549 cells after 72 hrs by SRB method Cytotoxicity against human A549 cells after 72 hrs by SRB method	[PMID: 19324555]
A549	IC₅₀	7.47 nM Compound: PT	Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 21916509]
A549	IC₅₀	7.63 μM Compound: 1	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 17988764]
A549	IC₅₀	9.34 μM Compound: 1; PPT	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 28757065]
A549	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
ACHN	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human ACHN cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
ACHN	IC₅₀	1.93 μM Compound: 1	Anticancer activity against human ACHN cells after 48 hrs by MTT assay Anticancer activity against human ACHN cells after 48 hrs by MTT assay	[PMID: 24721832]
ACHN	IC₅₀	2.12 μM Compound: 1	Anticancer activity against human ACHN cells after 48 hrs by MTT assay Anticancer activity against human ACHN cells after 48 hrs by MTT assay	[PMID: 22136907]
ACHN	IC₅₀	2.3 μM Compound: 1, Podo	Cytotoxicity against human ACHN cells after 72 hrs by MTT assay Cytotoxicity against human ACHN cells after 72 hrs by MTT assay	[PMID: 23182091]
AGS	IC₅₀	50.8 μM Compound: 1, VP-16	Cytotoxicity against human AGS cells after 72 hrs by SRB method Cytotoxicity against human AGS cells after 72 hrs by SRB method	[PMID: 19324555]
B16	IC₅₀	2.12 μM Compound: 1; PPT	Cytotoxicity against human B16 cells after 48 hrs by MTT assay Cytotoxicity against human B16 cells after 48 hrs by MTT assay	[PMID: 30108892]
B16	IC₅₀	2.5 μM Compound: 1, Podo	Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay	[PMID: 23182091]
BEAS-2B	IC₅₀	14.3 μM Compound: PPT	Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
BGC-823	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
BJ	IC₅₀	5 μM Compound: PDX	Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human BJ cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
BJ	IC₅₀	> 50 μM Compound: B	Cytotoxicity against human BJ cells after 72 hrs by luminescence assay Cytotoxicity against human BJ cells after 72 hrs by luminescence assay	[PMID: 20129783]
BT-549	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human BT549 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Bel-7402	IC₅₀	0.009 μM Compound: podophyllotoxin	Antiproliferative activity against human Bel7402 cells Antiproliferative activity against human Bel7402 cells	[PMID: 17977727]
Bel-7402	IC₅₀	0.016 μM Compound: Podo	Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
Bel-7402	IC₅₀	0.04 μM Compound: Podo	Antiproliferation activity against human Bel-7402 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human Bel-7402 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
Bel-7402	IC₅₀	0.052 μM Compound: 1; PPT	Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
Bel-7402	IC₅₀	9.1 nM Compound: podophyllotoxin	Antiproliferative activity against human Bel7402 cells after 72 hrs Antiproliferative activity against human Bel7402 cells after 72 hrs	[PMID: 17034133]
Bel-7402	IC₅₀	9.1 nM Compound: podophyllotoxin	Antiproliferative activity against human Bel-7402 cells Antiproliferative activity against human Bel-7402 cells	[PMID: 17197178]
Bel-7402	IC₅₀	9.1 nM Compound: podophyllotoxin	Antiproliferative activity against human Bel7402 cells Antiproliferative activity against human Bel7402 cells	[PMID: 17482458]
Bel7402/5-FU	IC₅₀	0.044 μM Compound: 1; PPT	Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
C8166	EC₅₀	0.0029 μM Compound: 1, podophyllotoxin	Antiviral activity against HIV1 in C8166 cells assessed as inhibition of syncytia formation Antiviral activity against HIV1 in C8166 cells assessed as inhibition of syncytia formation	[PMID: 17317161]
C8166	IC₅₀	< 0.15 μM Compound: 1, podophyllotoxin	Cytotoxicity against C8166 cells assessed as reduction in total cell number Cytotoxicity against C8166 cells assessed as reduction in total cell number	[PMID: 17317161]
CAKI-1	GI₅₀	89.7 nM Compound: PT, NSC 24818	Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human CAKI-1 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
CAL-51	GI₅₀	0.013 μM Compound: 1	Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human CAL-51 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
CCRF-CEM	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human CCRF-CEM cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
CCRF-CEM	IC₅₀	7.2 nM Compound: podophyllotoxin	Cytotoxicity against human CEM cells Cytotoxicity against human CEM cells	[PMID: 17197178]
CCRF-CEM	IC₅₀	7.2 nM Compound: podophyllotoxin	Antiproliferative activity against human CEM cells Antiproliferative activity against human CEM cells	[PMID: 17482458]
COLO 205	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human COLO205 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
COLO 205	IC₅₀	5 μM Compound: 1	Cytotoxicity against human COLO205 assessed as inhibition of cell growth Cytotoxicity against human COLO205 assessed as inhibition of cell growth	[PMID: 21144748]
CV-1	IC₅₀	0.029 μM Compound: 1 (Podophyllotoxin)	Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line. Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line.	10.1016/0960-894X(95)00432-S
CV-1	IC₅₀	0.05 μM Compound: 4	Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation	[PMID: 9834179]
Ca-Ski	IC₅₀	0.3 μM Compound: PDX	Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human CaSki cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
Caco-2	IC₅₀	0.002 μM Compound: podophyllotoxin	Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay Cytotoxicity against human CaCO2 cells after 24 hrs by MTT assay	[PMID: 18586491]
Caco-2	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay Cytotoxicity against human Caco-2 cells after 24 hrs by MTS assay	[PMID: 19880222]
Calu-1	IC₅₀	2.68 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human Calu-1 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
Col2	ED₅₀	0.005 μg/mL Compound: 12	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8277312]
DLD-1	IC₅₀	0.11 μM Compound: PDT	Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
DMS-79	IC₅₀	23 nM Compound: podophyllotoxin	Antiproliferative activity against human DMS79 cells after 72 hrs Antiproliferative activity against human DMS79 cells after 72 hrs	[PMID: 17034133]
DU-145	GI₅₀	0.04 μM Compound: 1	In vitro cytotoxic activity against prostate (DU-145) cancer cell line. In vitro cytotoxic activity against prostate (DU-145) cancer cell line.	[PMID: 10465531]
DU-145	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human DU145 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
DU-145	IC₅₀	0.01 μM Compound: PPT	Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay Antiproliferative activity against human DU145 cells after 96 hrs by SRB assay	[PMID: 27187855]
DU-145	IC₅₀	0.052 μM Compound: podophyllotoxin	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17977727]
DU-145	IC₅₀	0.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Growth inhibition of human DU145 cells after 48 hrs by MTT assay Growth inhibition of human DU145 cells after 48 hrs by MTT assay	[PMID: 28131777]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28648953]
DU-145	IC₅₀	0.063 μM Compound: Podophyllotoxin	Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
DU-145	IC₅₀	2.97 μM Compound: 1	Cytotoxicity against human DU145 cells by sulforhodamine B assay Cytotoxicity against human DU145 cells by sulforhodamine B assay	[PMID: 17988764]
DU-145	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells by MTT assay Antiproliferative activity against human DU145 cells by MTT assay	[PMID: 31546197]
DU-145	IC₅₀	3.11 μM Compound: IV	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 29289881]
DU-145	IC₅₀	3.21 μM Compound: 1	Anticancer activity against human DU145 cells after 48 hrs by MTT assay Anticancer activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 24721832]
DU-145	IC₅₀	4.15 μM Compound: Podophyllotoxin	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	[PMID: 29289884]
DU-145	IC₅₀	52 nM Compound: podophyllotoxin	Antiproliferative activity against human DU145 cells after 72 hrs Antiproliferative activity against human DU145 cells after 72 hrs	[PMID: 17034133]
DU-145	IC₅₀	52 nM Compound: podophyllotoxin	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17197178]
DU-145	IC₅₀	52 nM Compound: podophyllotoxin	Antiproliferative activity against human DU145 cells Antiproliferative activity against human DU145 cells	[PMID: 17482458]
DU-145	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
DU-145	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 22687745]
DU-145	IC₅₀	> 100 μM Compound: Podophyllotoxing	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 25462233]
EKVX	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human EKVX cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Erythrocyte	IC₅₀	7 ng/mL Compound: podophyllotoxin	Cytotoxicity against human erythrocytes Cytotoxicity against human erythrocytes	[PMID: 19199815]
FaDu	IC₅₀	7.2 nM Compound: podophyllotoxin	Antiproliferative activity against human CEM cells after 72 hrs Antiproliferative activity against human CEM cells after 72 hrs	[PMID: 17034133]
HCC 2998	GI₅₀	0.2 μM Compound: 1	In vitro cytotoxicity against human colon cancer HCC 2998 cell line In vitro cytotoxicity against human colon cancer HCC 2998 cell line	[PMID: 9871772]
HCC 2998	GI₅₀	12.3 nM Compound: PT, NSC 24818	Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCC2998 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HCT-116	GI₅₀	0.01 μM Compound: 1	In vitro cytotoxicity against human colon cancer HCT 116 cell line In vitro cytotoxicity against human colon cancer HCT 116 cell line	[PMID: 9871772]
HCT-116	GI₅₀	0.013 μM Compound: 1	Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by SRB proliferation assay	[PMID: 37849542]
HCT-116	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCT116 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HCT-116	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against human HCT116 Cytotoxicity against human HCT116	[PMID: 26916436]
HCT-116	IC₅₀	0.02 μM Compound: PPT	Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 27187855]
HCT-116	IC₅₀	> 20 μM Compound: Podophyllotoxin	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
HCT-15	GI₅₀	0.02 μM Compound: 1	In vitro cytotoxicity against human colon cancer HCT 15 cell line In vitro cytotoxicity against human colon cancer HCT 15 cell line	[PMID: 9871772]
HCT-15	GI₅₀	13.5 nM Compound: PT, NSC 24818	Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HCT15 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HCT-15	IC₅₀	0.061 μM Compound: Podophyllotoxin	Growth inhibition of human HCT15 cells after 48 hrs by MTT assay Growth inhibition of human HCT15 cells after 48 hrs by MTT assay	[PMID: 28131777]
HCT-15	IC₅₀	0.061 μM Compound: Podophyllotoxin	Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 48 hrs by MTT assay	[PMID: 28648953]
HCT-15	IC₅₀	1 μM Compound: 1	Cytotoxicity against human HCT-15 cells by sulforhodamine B assay Cytotoxicity against human HCT-15 cells by sulforhodamine B assay	[PMID: 17988764]
HCT-8	IC₅₀	1.68 μM Compound: PPT	Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
HEK-293T	IC₅₀	1.54 μM Compound: Podophyllotoxin	Cytotoxicity against HEK293T cells after 36 hrs by MTT assay Cytotoxicity against HEK293T cells after 36 hrs by MTT assay	[PMID: 27262599]
HEK-293T	IC₅₀	20 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 37550948]
HEK293	IC₅₀	0.017 μM Compound: B	Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay	[PMID: 20129783]
HEK293	IC₅₀	0.12 μg/mL Compound: Podophyllotoxin	Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay Cytotoxic activity against HEK293 cells after 24 hrs by MTT assay	[PMID: 25305717]
HEK293	IC₅₀	50 μM Compound: PDT	Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay Cytotoxicity against human HEK293 cells after 24 hrs by MTT assay	[PMID: 24457094]
HEp-2	IC₅₀	1.42 μM Compound: 1	Cytotoxicity against human HEP2 cells by sulforhodamine B assay Cytotoxicity against human HEP2 cells by sulforhodamine B assay	[PMID: 17988764]
HL-60	IC₅₀	0.48 μM Compound: PPT	Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay Antiproliferative activity against human HL60 cells after 96 hrs by SRB assay	[PMID: 27187855]
HL-60	IC₅₀	2.75 μM Compound: 1, VP-16	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 19324555]
HL-60(TB)	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HL-60(TB) cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HMEC	IC₅₀	1338 nM Compound: PPT	Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
HMEC	IC₅₀	5.6 μM Compound: PTOX	Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HMEC cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HOP-62	GI₅₀	21.1 nM Compound: PT, NSC 24818	Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HOP62 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HOP-62	IC₅₀	13.1 μM Compound: 1	Cytotoxicity against human HOP62 assessed as inhibition of cell growth Cytotoxicity against human HOP62 assessed as inhibition of cell growth	[PMID: 21144748]
HOP-92	GI₅₀	34.1 nM Compound: PT, NSC 24818	Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HOP92 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HT	ED₅₀	0.003 μg/mL Compound: 12	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8277312]
HT-1080	IC₅₀	8.1 μM Compound: 1	Cytotoxicity against human HT1080 assessed as inhibition of cell growth Cytotoxicity against human HT1080 assessed as inhibition of cell growth	[PMID: 21144748]
HT-29	ED₅₀	4.7 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 7714533]
HT-29	GI₅₀	0.01 μM Compound: 1	In vitro cytotoxicity against human colon cancer HT 29 cell line In vitro cytotoxicity against human colon cancer HT 29 cell line	[PMID: 9871772]
HT-29	GI₅₀	0.024 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 20067289]
HT-29	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human HT-29 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
HT-29	GI₅₀	12 nM Compound: 1a	Growth inhibition of human HT-29 cells after 72 hrs by SRB assay Growth inhibition of human HT-29 cells after 72 hrs by SRB assay	[PMID: 22607205]
HT-29	IC₅₀	0.0029 μM Compound: 1	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 7673931]
HT-29	IC₅₀	0.0043 μg/mL Compound: 2	Growth inhibition of HT-29 (human colon adenocarcinoma) cell line. Growth inhibition of HT-29 (human colon adenocarcinoma) cell line.	[PMID: 2002477]
HT-29	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against human HT29 cells after 4 days Cytotoxicity against human HT29 cells after 4 days	[PMID: 17197187]
HT-29	IC₅₀	0.02 μM Compound: PPT	Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 27187855]
HT-29	IC₅₀	0.023 μM Compound: PPT	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HT-29	IC₅₀	0.024 μM Compound: 1	In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line. In vitro cytotoxicity against HT-29 (human colon carcinoma) cell line.	[PMID: 14971901]
HT-29	IC₅₀	0.029 μM Compound: 1 (Podophyllotoxin)	Antineoplastic activity against HT-29 (human colon carcinoma) cell line. Antineoplastic activity against HT-29 (human colon carcinoma) cell line.	10.1016/0960-894X(95)00432-S
HT-29	IC₅₀	0.05 μM Compound: 6 (Podophyllotoxin)	Compound was tested for inhibition of cell growth of HT-29 cells Compound was tested for inhibition of cell growth of HT-29 cells	10.1016/0960-894X(95)00008-H
HT-29	IC₅₀	0.066 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 29670695]
HT-29	IC₅₀	0.78 μM Compound: 1	Anticancer activity against human HT-29 cells after 48 hrs by MTT assay Anticancer activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 22136907]
HT-29	IC₅₀	1.02 μM Compound: 1, Podo	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23182091]
HT-29	IC₅₀	1.26 μM Compound: 1; PPT	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 30108892]
HT-29	IC₅₀	1.75 μM Compound: PPT	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
HT-29	IC₅₀	11 nM Compound: Podophyllotoxin	Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay	[PMID: 2778449]
HT-29	IC₅₀	2.29 μM Compound: 1	Anticancer activity against human HT-29 cells after 48 hrs by MTT assay Anticancer activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 24721832]
HT-29	IC₅₀	2.99 μM Compound: IV	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 29289881]
HT-29	IC₅₀	2900 nM Compound: 2d	In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line	[PMID: 14980682]
HT-29	IC₅₀	4.78 μM Compound: Podophyllotoxin	Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 29289884]
HT-29	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human HT-29 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
HUVEC	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against HUVEC assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
HeLa	ED₅₀	20.5 μg/mL Compound: 3	Cytotoxicity against human HeLa cells after 4 days by trypan blue assay Cytotoxicity against human HeLa cells after 4 days by trypan blue assay	[PMID: 1602298]
HeLa	GI₅₀	0.02 μM Compound: 1	Growth inhibition of HeLa cells after 48 hrs by MTT assay Growth inhibition of HeLa cells after 48 hrs by MTT assay	[PMID: 17894480]
HeLa	GI₅₀	0.02 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21615090]
HeLa	GI₅₀	0.71 μM Compound: 1	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 24953821]
HeLa	GI₅₀	0.74 μM Compound: 1	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
HeLa	IC₅₀	0.012 μM Compound: 2; PPT	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
HeLa	IC₅₀	0.044 μM Compound: PPT	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
HeLa	IC₅₀	0.069 μM Compound: 6	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 2 days by MTT assay Cytotoxicity against human HeLa cells after 2 days by MTT assay	[PMID: 21821321]
HeLa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25113878]
HeLa	IC₅₀	0.14 μM Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs Cytotoxicity against human HeLa cells after 48 hrs	[PMID: 23022053]
HeLa	IC₅₀	1.45 μM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells after 36 hrs by MTT assay Cytotoxicity against human HeLa cells after 36 hrs by MTT assay	[PMID: 27262599]
HeLa	IC₅₀	1.92 μM Compound: 1	Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay Cytotoxicity against human HeLa cells assessed as cell viability by SRB assay	[PMID: 26022842]
HeLa	IC₅₀	14 nM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells overexpressing tubulin beta3 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
HeLa	IC₅₀	15.5 nM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HeLa	IC₅₀	17 nM Compound: Podophyllotoxin	Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 35344902]
HeLa	IC₅₀	18 nM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HeLa	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
HeLa	IC₅₀	2.36 μM Compound: 1; PPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30108892]
HeLa	IC₅₀	2.8 μM Compound: 1, Podo	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 23182091]
HeLa	IC₅₀	2.81 μM Compound: 1	Anticancer activity against human HeLa cells after 48 hrs by MTT assay Anticancer activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 24721832]
HeLa	IC₅₀	3.04 μM Compound: IV	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29289881]
HeLa	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 31546197]
HeLa	IC₅₀	3.14 μg/mL Compound: Podophyllotoxin	Anticancer activity against human HeLa cells after 24 hrs by MTT assay Anticancer activity against human HeLa cells after 24 hrs by MTT assay	[PMID: 25305717]
HeLa	IC₅₀	3.45 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 29289884]
HeLa	IC₅₀	6.9 μM Compound: PTOX	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HeLa	IC₅₀	6.9 μM Compound: Podophyllotoxin	Antiproliferative activity against human HeLa cells assessed as reduction in cell growth Antiproliferative activity against human HeLa cells assessed as reduction in cell growth	[PMID: 38107170]
HeLa	IC₅₀	7.45 μM Compound: 1; PPT	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 hrs by MTT assay	[PMID: 28757065]
HeLa	IC₅₀	7.58 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 22687745]
HeLa	IC₅₀	7.58 μM Compound: Podophyllotoxing	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25462233]
HepG2	CC₅₀	< 0.5 μM Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability Cytotoxicity against human HepG2 cells assessed as reduction in cell viability	[PMID: 32527539]
HepG2	IC₅₀	0.003 μM Compound: Podo	Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
HepG2	IC₅₀	0.008 μM Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29609908]
HepG2	IC₅₀	0.014 μM Compound: 2; PPT	Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
HepG2	IC₅₀	0.024 μM Compound: B	Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay	[PMID: 20129783]
HepG2	IC₅₀	0.5 μM Compound: 2	Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay	[PMID: 19880222]
HepG2	IC₅₀	0.51 μM Compound: 1	Cytotoxicity against human HepG2 cells after 48 hrs Cytotoxicity against human HepG2 cells after 48 hrs	[PMID: 23022053]
HepG2	IC₅₀	19.6 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 37550948]
HepG2	IC₅₀	2.27 μM Compound: 1	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22687745]
HepG2	IC₅₀	2.27 μM Compound: Podophyllotoxing	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25462233]
HepG2	IC₅₀	2.4 μM Compound: PTOX	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
HepG2	IC₅₀	2.4 μM Compound: Podophyllotoxin	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38107170]
HepG2	IC₅₀	209 nM Compound: PPT	Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against hypoxia-induced human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
HepG2	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 31546197]
HepG2	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
HepG2	IC₅₀	4.8 μM Compound: podophyllotoxin	Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay Cytotoxicity against human HEPG2 cells after 24 hrs by MTT assay	[PMID: 18586491]
HepG2	IC₅₀	5.81 μM Compound: 1; PPT	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 28757065]
HepG2	IC₅₀	6.63 μM Compound: Podophyllotoxin	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 29289884]
HepG2	IC₅₀	83 nM Compound: PPT	Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells overexpressing NQO1 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
HepG2	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
HepG2	IC₅₀	> 200000 nM Compound: PPT	Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
Hs-578T	GI₅₀	0.08 μM Compound: 1	In vitro cytotoxicity against human breast cancer Hs 578.T cell line In vitro cytotoxicity against human breast cancer Hs 578.T cell line	[PMID: 9871772]
Hs-578T	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human Hs 578T cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
IGROV-1	GI₅₀	13.2 nM Compound: PT, NSC 24818	Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human IGROV1 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
J774	IC₅₀	0.023 μM Compound: Podophyllotoxin	Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against mouse J774 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31732409]
J774	IC₅₀	16.4 nM Compound: Podophyllotoxin	Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells Inhibitory concentration required for cytotoxicity in J774.2 murine macrophage-like cells	10.1016/0960-894X(95)00300-I
J774	IC₅₀	18 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774 cells Cytotoxicity against mouse J774 cells	[PMID: 22765899]
J774.2	IC₅₀	11.3 nM Compound: Podophyllotoxin	Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells Inhibitory concentration required for cytotoxicity in hydroxyrubicin-resistant (WP159/R) cells	10.1016/0960-894X(95)00300-I
J774.2	IC₅₀	13.4 nM Compound: Podophyllotoxin	Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells Inhibitory concentration required for cytotoxicity in DOX-resistant (DOX/R) cells	10.1016/0960-894X(95)00300-I
J774.A1	EC₅₀	21 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Cytotoxicity against mouse J774A.1 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25749014]
J774.A1	EC₅₀	250 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay Cytotoxicity against mouse J774A1 cells after 72 hrs by MTT assay	[PMID: 24874647]
J774.A1	EC₅₀	250 nM Compound: Podophyllotoxin	Cytotoxicity against mouse J774.A1 cells Cytotoxicity against mouse J774.A1 cells	[PMID: 38909569]
Jurkat	IC₅₀	25 nM Compound: PT	Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay Cytotoxicity against human Jurkat cells assessed as cell viability after 48 hrs by trypan blue exclusion assay	[PMID: 21916509]
Jurkat	IC₅₀	25 nM Compound: PT, NSC 24818	Cytotoxicity against human Jurkat cells Cytotoxicity against human Jurkat cells	[PMID: 22370267]
K562	GI₅₀	215.3 nM Compound: PT, NSC 24818	Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human K562 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
K562	IC₅₀	0.006 μM Compound: 1; PPT	Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 27503681]
K562	IC₅₀	0.006 μM Compound: 2; PPT	Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human K562 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
K562	IC₅₀	0.013 μg/mL Compound: Podophyllotoxin	Anticancer activity against human K562 cells after 24 hrs by MTT assay Anticancer activity against human K562 cells after 24 hrs by MTT assay	[PMID: 25305717]
K562	IC₅₀	0.025 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 29678463]
K562	IC₅₀	0.03 μM Compound: Podophyllotoxin	Cytotoxicity against human K562 cells after 2 days by MTT assay Cytotoxicity against human K562 cells after 2 days by MTT assay	[PMID: 21821321]
K562	IC₅₀	0.03 μM Compound: Podophyllotoxin	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 25113878]
K562	IC₅₀	0.35 μM Compound: Podophyllotoxin	Inhibition of tubulin polymerization in human K562 cells Inhibition of tubulin polymerization in human K562 cells	[PMID: 20546980]
K562	IC₅₀	18.39 μM Compound: PDT	Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human K562 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
K562	IC₅₀	4.51 μM Compound: 1	Cytotoxicity against human K562 cells after 48 hrs Cytotoxicity against human K562 cells after 48 hrs	[PMID: 23022053]
K562	IC₅₀	> 100 μM Compound: 1, VP-16	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 19324555]
K562/A02	IC₅₀	0.17 μM Compound: Podophyllotoxin	Cytotoxicity against human K562/A02 cells after 2 days by MTT assay Cytotoxicity against human K562/A02 cells after 2 days by MTT assay	[PMID: 21821321]
K562/A02	IC₅₀	0.17 μM Compound: Podophyllotoxin	Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay Cytotoxicity against human K562/A02 cells after 48 hrs by MTT assay	[PMID: 25113878]
K562/Adr	IC₅₀	0.025 μM Compound: 1; PPT	Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay	[PMID: 27503681]
K562/Adr	IC₅₀	0.085 μM Compound: 2; PPT	Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay Antiproliferative activity against human K562/ADR cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 26615886]
K562/VCR	IC₅₀	0.05 μM Compound: 1	Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay Antiproliferative activity against human K562/VCR cells after 72 hrs by CCK8 assay	[PMID: 29678463]
KB	CC₅₀	0.048 μM Compound: podophylotoxin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 17548196]
KB	ED₅₀	0.0003 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 8158163]
KB	ED₅₀	0.008 μg/mL Compound: Podophyllotoxin	Toxicity of the quinacrine derivatives was determined against the KB cell line in comparison to podophyllotoxin Toxicity of the quinacrine derivatives was determined against the KB cell line in comparison to podophyllotoxin	[PMID: 11551771]
KB	ED₅₀	0.07 μM Compound: podophyllotoxin	Cytotoxicity against human KB cells by Alamar blue assay Cytotoxicity against human KB cells by Alamar blue assay	[PMID: 16279799]
KB	ED₅₀	0.08 μg/mL Compound: 12	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8277312]
KB	ED₅₀	0.2 nM Compound: Podophyllotoxin	The toxicity was evaluated against KB cells The toxicity was evaluated against KB cells	[PMID: 11459645]
KB	ED₅₀	< 0.3 μg/mL Compound: 18 (-)-Podophyllotoxin	In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma. In vitro effective dose to inhibit KB cell growth from a human epidermoid carcinoma.	[PMID: 1992152]
KB	ED₅₀	< 1 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7130986]
KB	IC₅₀	0.0005 μM Compound: POD	Cytotoxicity against human KB cells assessed as growth inhibition Cytotoxicity against human KB cells assessed as growth inhibition	[PMID: 21705220]
KB	IC₅₀	0.0007 μM Compound: POD	Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay	[PMID: 24900724]
KB	IC₅₀	0.002 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human KB cells assessed as reduction in cell viability Cytotoxicity against human KB cells assessed as reduction in cell viability	[PMID: 31515186]
KB	IC₅₀	0.003 μM Compound: POD	Cytotoxicity against human KB cells after 48 hrs by alamar blue assay Cytotoxicity against human KB cells after 48 hrs by alamar blue assay	[PMID: 18215443]
KB	IC₅₀	0.0036 μM Compound: podophyllotoxin	Cytotoxicity against KB cell line Cytotoxicity against KB cell line	[PMID: 16343898]
KB	IC₅₀	0.0048 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells by alamar blue assay Cytotoxicity against human KB cells by alamar blue assay	[PMID: 12141852]
KB	IC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15104480]
KB	IC₅₀	0.006 μg/mL Compound: podophyllotoxin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11421727]
KB	IC₅₀	0.008 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11141105]
KB	IC₅₀	0.056 μM Compound: 6	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB	IC₅₀	0.058 μM Compound: Podophyllotoxin	Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar blue assay	[PMID: 28189085]
KB	IC₅₀	11.7 nM Compound: Podophyllotoxin	Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human KB cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24148834]
KB	IC₅₀	3.21 nM Compound: Podo	Antiproliferation activity against human KB cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human KB cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
KB	IC₅₀	6.21 x 10^-3 μg/mL Compound: podophyllotoxin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 12398543]
KB-V1	ED₅₀	0.06 μg/mL Compound: 12	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 8277312]
KM12	GI₅₀	0.01 μM Compound: 1	In vitro cytotoxicity against human colon cancer KM 12 cell line In vitro cytotoxicity against human colon cancer KM 12 cell line	[PMID: 9871772]
KM12	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human KM12 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
L02	IC₅₀	0.022 μM Compound: 1; PPT	Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay	[PMID: 28301815]
L02	IC₅₀	2.97 μM Compound: Ref 34, Cpd 1	Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay Cytotoxicity against human L02 cells incubated for 24 hrs by CCK8 assay	[PMID: 32992133]
L02	IC₅₀	3.16 μM Compound: Ref 34, Cpd 1	Cytotoxicity against human L02 cells Cytotoxicity against human L02 cells	[PMID: 32992133]
L02	IC₅₀	3.72 μM Compound: 1; PPT	Cytotoxicity against human L02 cells after 24 hrs by MTT assay Cytotoxicity against human L02 cells after 24 hrs by MTT assay	[PMID: 28757065]
L02	IC₅₀	32.76 nM Compound: Podo	Antiproliferation activity against human L02 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human L02 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
L02	IC₅₀	4.31 μM Compound: Ref 34, Cpd 1	Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HL7702 cells incubated for 48 hrs by MTT assay	[PMID: 32992133]
L02	IC₅₀	5 μM Compound: PTOX	Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HL7702 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
L02	IC₅₀	85 nM Compound: PPT	Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against NQO1-deficient human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33091789]
L1210	IC₅₀	0.0036 μg/mL Compound: 1	Tested for in vitro cytotoxicity against L1210 murine leukemia cells in mice Tested for in vitro cytotoxicity against L1210 murine leukemia cells in mice	10.1016/0960-894X(95)00172-P
L6	CC₅₀	0.007 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 30006174]
L6	CC₅₀	0.007 μM Compound: PPT	Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis Cytotoxicity against rat L6 cels assessed as reduction in cell viability after 72 hrs by Alamar Blue dye-based fluorometric analysis	[PMID: 30615444]
L6	CC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25642604]
L6	CC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 48 hrs by Alamar Blue assay	[PMID: 24354316]
L6	CC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 70 hrs by Alamar blue assay	[PMID: 33070078]
L6	EC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy Cytotoxicity against rat L6 cells incubated for 72 hrs by alamar blue staining based microscopy	[PMID: 26408453]
L6	EC₅₀	0.007 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 24978605]
L6	EC₅₀	0.009 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23517371]
L6	EC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 23916149]
L6	EC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22390399]
L6	EC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay Cytotoxicity against rat L6 cells incubated for 70 hrs by resazurin dye based assay	[PMID: 32134269]
L6	EC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay	[PMID: 23831695]
L6	EC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 38823730]
L6	EC₅₀	14 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 20185305]
L6	IC₅₀	0.001 μM Compound: PDT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 24900706]
L6	IC₅₀	0.0017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy	[PMID: 23153330]
L6	IC₅₀	0.002 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 26237241]
L6	IC₅₀	0.004 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorometric analysis	[PMID: 20855214]
L6	IC₅₀	0.004 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22352841]
L6	IC₅₀	0.005 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 30916554]
L6	IC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Toxicity against rat L6 cells after 72 hrs by Alamar blue assay Toxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23313632]
L6	IC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability Cytotoxicity against rat L6 cells assessed as reduction in cell viability	[PMID: 31515186]
L6	IC₅₀	0.005 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 72 hrs by Resazurin-dye based assay Cytotoxicity against rat L6 cells incubated for 72 hrs by Resazurin-dye based assay	[PMID: 37942619]
L6	IC₅₀	0.005 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17253841]
L6	IC₅₀	0.006 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis	[PMID: 24063369]
L6	IC₅₀	0.006 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 4 days Cytotoxicity against rat L6 cells after 4 days	[PMID: 17475370]
L6	IC₅₀	0.006 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay	[PMID: 34091216]
L6	IC₅₀	0.006 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 18683985]
L6	IC₅₀	0.007 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 29244495]
L6	IC₅₀	0.007 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorimetry analysis	[PMID: 31799840]
L6	IC₅₀	0.007 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17990865]
L6	IC₅₀	0.007 μg/mL Compound: POD	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay	[PMID: 29220797]
L6	IC₅₀	0.007 μg/mL Compound: Pod	Cytotoxicity against rat L6 cells by alamar blue assay Cytotoxicity against rat L6 cells by alamar blue assay	[PMID: 19010569]
L6	IC₅₀	0.007 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay	[PMID: 22217867]
L6	IC₅₀	0.007 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 20307077]
L6	IC₅₀	0.008 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis Cytotoxicity against rat L6 cells after 70 hrs by microscopic analysis	[PMID: 23320609]
L6	IC₅₀	0.0082 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 28537728]
L6	IC₅₀	0.008 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19015351]
L6	IC₅₀	0.009 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 30565934]
L6	IC₅₀	0.009 μM Compound: podophyllotoxin	Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay Cytotoxicity at rat L6 cells after 72 hrs by microplate alamar blue assay	[PMID: 21644541]
L6	IC₅₀	0.0097 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 25195945]
L6	IC₅₀	0.009 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs Cytotoxicity against rat L6 cells after 72 hrs	[PMID: 17765547]
L6	IC₅₀	0.01 μM Compound: PDP	Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay	[PMID: 28789893]
L6	IC₅₀	0.01 μM Compound: PPT	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17948982]
L6	IC₅₀	0.01 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19267462]
L6	IC₅₀	0.01 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19606902]
L6	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19942439]
L6	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 28840725]
L6	IC₅₀	0.01 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 30302998]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17949068]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 21348447]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay Cytotoxicity against rat L6 myoblasts after 72 hrs by alamar blue assay	[PMID: 22285027]
L6	IC₅₀	0.01 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 23968432]
L6	IC₅₀	0.012 μM Compound: 19	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19414258]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay	[PMID: 27344215]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by alamar blue assay	[PMID: 28031151]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue staining based fluorometric assay	[PMID: 28279559]
L6	IC₅₀	0.012 μM Compound: POD	Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 30962114]
L6	IC₅₀	0.012 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 20047276]
L6	IC₅₀	0.012 μM Compound: Pod	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 18571774]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 21112788]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin-based spectrophotometric assay	[PMID: 22061825]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 25871440]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 28666857]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 29172086]
L6	IC₅₀	0.012 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 72 hrs by Alamar blue based inverted microscopy analysis	[PMID: 31784198]
L6	IC₅₀	0.012 μM Compound: pod	Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar blue assay	[PMID: 33148495]
L6	IC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 16821778]
L6	IC₅₀	0.012 μM Compound: podophyllotoxin	Toxicity against rat L6 cells Toxicity against rat L6 cells	[PMID: 19781948]
L6	IC₅₀	0.012 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry Cytotoxicity against rat L6 cells after 72 hrs by microplate fluorimetry	[PMID: 21438586]
L6	IC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 21937228]
L6	IC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 24865793]
L6	IC₅₀	0.014 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by alamar blue assay	[PMID: 28284860]
L6	IC₅₀	0.014 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay Cytotoxicity against rat L6 cells after 72 hrs by resazurin assay	[PMID: 17709461]
L6	IC₅₀	0.0145 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin dye based fluorescence assay	[PMID: 33524940]
L6	IC₅₀	0.0145 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay Cytotoxicity against rat L6 cells after 70 hrs by resazurin reduction assay	[PMID: 23301592]
L6	IC₅₀	0.016 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 28116906]
L6	IC₅₀	0.0169 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells by alamar blue assay Cytotoxicity against rat L6 cells by alamar blue assay	[PMID: 27387356]
L6	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 19409677]
L6	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 23795673]
L6	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay Cytotoxicity against rat L6 cells assessed as cell viability after 70 hrs by Alamar blue assay	[PMID: 24268543]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 20850207]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar Blue assay	[PMID: 24471526]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay Cytotoxicity against rat L6 cells after 3 days by Alamar blue assay	[PMID: 24956553]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25740635]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis	[PMID: 27102161]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay	[PMID: 28121440]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay Cytotoxicity in rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue dye based assay	[PMID: 28988153]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence assay	[PMID: 29043798]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue dye-based fluorometric analysis	[PMID: 31642313]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 70 hrs by resazurin staining based inverted microscopic analysis	[PMID: 32745819]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 70 hrs by resazurin dye based assay	[PMID: 33901399]
L6	IC₅₀	0.017 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability by resazurin dye based assay	[PMID: 36972793]
L6	IC₅₀	0.018 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay	[PMID: 30975502]
L6	IC₅₀	0.018 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue assay	[PMID: 31550659]
L6	IC₅₀	0.0186 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17439202]
L6	IC₅₀	0.018 μg/mL Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 15921407]
L6	IC₅₀	0.019 mM Compound: PPT	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23871911]
L6	IC₅₀	0.019 μM Compound: PPT	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 18841956]
L6	IC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay Cytotoxicity against rat L6 cells incubated for 72 hrs by Alamar Blue staining based fluorometric assay	[PMID: 21846091]
L6	IC₅₀	0.019 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23265884]
L6	IC₅₀	0.019 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells by Alamar blue assay Cytotoxicity against rat L6 cells by Alamar blue assay	[PMID: 17922552]
L6	IC₅₀	0.019 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 22738640]
L6	IC₅₀	0.0193 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis	[PMID: 24900574]
L6	IC₅₀	0.02 μM Compound: PPT	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 19928900]
L6	IC₅₀	0.02 μM Compound: Podo	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	10.1039/C5MD00498E
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	10.1039/C2MD20136D
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 22932312]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 24673206]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method Cytotoxicity against rat L6 cells after 72 hrs by AlamarBlue dye based fluorimetric method	[PMID: 26849852]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 70 hrs by alamar blue assay	[PMID: 29896963]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by resazurin dye based inverted microscopic analysis	[PMID: 33095014]
L6	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis Cytotoxicity against rat L6 cells measured after 72 hrs by alamar blue dye based fluorometric analysis	[PMID: 33843232]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 18476684]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 21868222]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay	[PMID: 24900723]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25080196]
L6	IC₅₀	0.02 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25314007]
L6	IC₅₀	0.021 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells by MTT assay Cytotoxicity against rat L6 cells by MTT assay	[PMID: 21456549]
L6	IC₅₀	0.022 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis	10.1039/C4MD00406J
L6	IC₅₀	0.022 μM Compound: podoph	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 22550999]
L6	IC₅₀	0.024 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 33002847]
L6	IC₅₀	0.02 μg/mL Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25103602]
L6	IC₅₀	0.041 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 29560715]
L6	IC₅₀	0.041 μM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability incubated for 72 hrs by Alamar blue staining-based fluorometric analysis	[PMID: 31630523]
L6	IC₅₀	0.15 μM Compound: podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 16677813]
L6	IC₅₀	11 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue dye-based fluorometric analysis	[PMID: 34095848]
L6	IC₅₀	14.5 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue assay	[PMID: 24721829]
L6	IC₅₀	14.5 nM Compound: Podophylotoxin	Toxicity against rat L6 cells after 72 hrs by Alamar blue assay Toxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23360309]
L6	IC₅₀	14.5 nM Compound: Podophylotoxin	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis	[PMID: 23685569]
L6	IC₅₀	19 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25563890]
L6	IC₅₀	5 nM Compound: Podophyllotoxin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25547934]
L929	IC₅₀	1.37 μM Compound: 1	Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay Cytotoxicity against mouse L929 cells after 72 hrs by MTT assay	[PMID: 22687745]
LNCaP	ED₅₀	0.04 μg/mL Compound: 12	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8277312]
LNCaP	IC₅₀	0.031 μM Compound: 2	Cytotoxicity against androgen sensitive human LNCaP cells Cytotoxicity against androgen sensitive human LNCaP cells	[PMID: 17256902]
LOX IMVI	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human LOXIMVI cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Lu1	ED₅₀	0.008 μg/mL Compound: 12	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8277312]
M14	GI₅₀	0.07 μM Compound: 1	In vitro cytotoxic activity against melanoma (M 14) cancer cell line. In vitro cytotoxic activity against melanoma (M 14) cancer cell line.	[PMID: 10465531]
M14	GI₅₀	13.1 nM Compound: PT, NSC 24818	Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human M14 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MCF-10A	IC₅₀	16.58 μM Compound: PPT	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
MCF7	ED₅₀	1.1 x 10^-6 μg/mL Compound: podophyllotoxin	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 7714533]
MCF7	GI₅₀	0.01 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21615090]
MCF7	GI₅₀	0.23 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 24953821]
MCF7	GI₅₀	0.31 μM Compound: 1	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
MCF7	GI₅₀	0.6 μM Compound: 1	In vitro cytotoxicity against human breast cancer MCF-7 ADR cell line In vitro cytotoxicity against human breast cancer MCF-7 ADR cell line	[PMID: 9871772]
MCF7	GI₅₀	0.9 μM Compound: 1	In vitro cytotoxicity against human breast cancer MCF-7 cell line In vitro cytotoxicity against human breast cancer MCF-7 cell line	[PMID: 9871772]
MCF7	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MCF7 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MCF7	IC₅₀	0.0001 μM Compound: 2	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	IC₅₀	0.0004 μM Compound: 2	Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	IC₅₀	0.005 μM Compound: Podophyllotoxin	Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
MCF7	IC₅₀	0.01 μM Compound: PPT	Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 27187855]
MCF7	IC₅₀	0.015 μM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17977727]
MCF7	IC₅₀	0.017 μM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
MCF7	IC₅₀	0.02 μM Compound: Podo	Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MCF7	IC₅₀	0.02 μM Compound: Podophyllotoxin	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	0.028 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29670695]
MCF7	IC₅₀	0.039 μM Compound: PPT	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MCF7	IC₅₀	0.2 μM Compound: Podophyllotoxin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	0.23 μM Compound: 1; PT	Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay Antiproliferative activity against human MCF7 cells after 96 hrs by propidium iodide-based monolayer assay	[PMID: 26854430]
MCF7	IC₅₀	0.28 μM Compound: PDX	Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
MCF7	IC₅₀	0.3 μM Compound: Podophyllotoxin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	1.11 μM Compound: Podophyllotoxin	Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay Cytotoxicity against human MCF7 cells after 36 hrs by MTT assay	[PMID: 27262599]
MCF7	IC₅₀	1.18 μM Compound: 1	Anticancer activity against human MCF7 cells after 48 hrs by MTT assay Anticancer activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22136907]
MCF7	IC₅₀	10.04 μM Compound: PDT	Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
MCF7	IC₅₀	10.86 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MCF-7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
MCF7	IC₅₀	15 nM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 17034133]
MCF7	IC₅₀	15 nM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17197178]
MCF7	IC₅₀	15 nM Compound: podophyllotoxin	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 17482458]
MCF7	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
MCF7	IC₅₀	16.67 μM Compound: PPT	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
MCF7	IC₅₀	2.13 μM Compound: Ref 34, Cpd 1	Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 24 hrs by MTT assay	[PMID: 32992133]
MCF7	IC₅₀	2.21 μM Compound: Podo	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30025350]
MCF7	IC₅₀	2.4 μM Compound: PTOX	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
MCF7	IC₅₀	2.4 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay	[PMID: 38107170]
MCF7	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 29289884]
MCF7	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 31546197]
MCF7	IC₅₀	3.34 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay Cytotoxicity against human MCF7 cells assessed as cell viability by SRB assay	[PMID: 26022842]
MCF7	IC₅₀	3.5 μM Compound: PDT, 4	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 22472045]
MCF7	IC₅₀	3.52 μg/mL Compound: Podophyllotoxin	Anticancer activity against human MCF7 cells after 24 hrs by MTT assay Anticancer activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 25305717]
MCF7	IC₅₀	3.75 μM Compound: 1; PPT	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30108892]
MCF7	IC₅₀	4.16 μM Compound: PDT	Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
MCF7	IC₅₀	64.99 μM Compound: PDT	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 24457094]
MCF7	IC₅₀	64.99 μM Compound: Podophyllotoxin	Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 32731188]
MCF7	IC₅₀	7.13 μM Compound: 1; PPT	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 28757065]
MCF7	IC₅₀	8.5 μM Compound: podophyllotoxin	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 18586491]
MCF7	IC₅₀	> 100 μM Compound: 1	Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human MCF7 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
MCF7	IC₅₀	> 200000 nM Compound: PPT	Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human MCF7 cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
MDA-MB-231	GI₅₀	0.04 μM Compound: 1	In vitro cytotoxicity against human breast cancer MDA-MB 231 cell line In vitro cytotoxicity against human breast cancer MDA-MB 231 cell line	[PMID: 9871772]
MDA-MB-231	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MDA-MB-231	IC₅₀	0.008 μM Compound: Podophyllotoxin	Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay Antiproliferative activity against estrogen-independent breast cancer MDA-MB-231 cell line by MTS assay	[PMID: 16213720]
MDA-MB-231	IC₅₀	0.017 μM Compound: PPT	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35447432]
MDA-MB-231	IC₅₀	0.026 μM Compound: Podophyllotoxin	Inhibition of the growth of MDA-MB 231 human breast cancer cells Inhibition of the growth of MDA-MB 231 human breast cancer cells	[PMID: 9357519]
MDA-MB-231	IC₅₀	0.079 μM Compound: podophyllotoxin	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
MDA-MB-231	IC₅₀	0.12 μM Compound: PPT	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by SRB assay	[PMID: 27187855]
MDA-MB-231	IC₅₀	20.22 μM Compound: PDT	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by Sulphorhodamine assay	[PMID: 37146520]
MDA-MB-231	IC₅₀	35.7 μM Compound: PDT	Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 24457094]
MDA-MB-231	IC₅₀	5.73 μM Compound: Podophyllotoxin	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
MDA-MB-231	IC₅₀	80.48 nM Compound: Podo	Antiproliferation activity against human MDA-MB-231 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human MDA-MB-231 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
MDA-MB-231	IC₅₀	9.49 μM Compound: PPT	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
MDA-MB-231	IC₅₀	9.76 μM Compound: IV	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 29289881]
MDA-MB-231	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
MDA-MB-435	GI₅₀	0.7 μM Compound: 1	In vitro cytotoxicity against human breast cancer MDA-MB 435 cell line In vitro cytotoxicity against human breast cancer MDA-MB 435 cell line	[PMID: 9871772]
MDA-MB-435	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MDA-MB-468	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MDA-MB-468 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MDA-N	GI₅₀	0.07 μM Compound: 1	In vitro cytotoxicity against human breast cancer MDA-N cell line In vitro cytotoxicity against human breast cancer MDA-N cell line	[PMID: 9871772]
MG-63	IC₅₀	0.007 μM Compound: 1	Cytotoxicity against human MG63 cells after 72 hrs by MTT assay Cytotoxicity against human MG63 cells after 72 hrs by MTT assay	[PMID: 29670695]
MG-63	IC₅₀	18.3 μM Compound: 1	Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method Cytotoxicity against human MG63 cells after 24 hrs by annexin-V-FITC/propidium iodide staining based flow cytometric method	[PMID: 29670695]
MIA PaCa-2	GI₅₀	0.51 μM Compound: 1	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 48 hrs by SRB assay	[PMID: 25131956]
MIA PaCa-2	IC₅₀	0.012 μM Compound: Podo	Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 27919655]
MIA PaCa-2	IC₅₀	19.67 nM Compound: Podo	Antiproliferation activity against human MIA PaCa-2 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human MIA PaCa-2 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
MOLT-3	IC₅₀	0.014 μM Compound: podophyllotoxin	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17977727]
MOLT-3	IC₅₀	14 nM Compound: podophyllotoxin	Antiproliferative activity against human Molt3 cells after 72 hrs Antiproliferative activity against human Molt3 cells after 72 hrs	[PMID: 17034133]
MOLT-3	IC₅₀	14 nM Compound: podophyllotoxin	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17197178]
MOLT-3	IC₅₀	14 nM Compound: podophyllotoxin	Antiproliferative activity against human Molt3 cells Antiproliferative activity against human Molt3 cells	[PMID: 17482458]
MOLT-4	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MOLT4 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
MRC5	IC₅₀	10.6 μM Compound: PTOX	Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30878833]
Malme-3M	GI₅₀	47315.1 nM Compound: PT, NSC 24818	Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human MALME-3M cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H1299	IC₅₀	1.33 μM Compound: PPT	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
NCI-H1975	IC₅₀	12.56 μM Compound: PPT	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay	[PMID: 37395092]
NCI-H226	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H226 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H23	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H23 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H322M	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H322M cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H460	GI₅₀	10.6 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H460 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI-H460	IC₅₀	24.58 nM Compound: Podo	Antiproliferation activity against human NCI-H460 cells measured after 72 hrs incubation by MTT assay Antiproliferation activity against human NCI-H460 cells measured after 72 hrs incubation by MTT assay	[PMID: 38781920]
NCI-H520	GI₅₀	0.7 μM Compound: 1	In vitro cytotoxic activity against lung (H 522) cancer cell line. In vitro cytotoxic activity against lung (H 522) cancer cell line.	[PMID: 10465531]
NCI-H522	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI-H522 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NCI/ADR-RES	GI₅₀	0.6 μM Compound: 1	In vitro cytotoxic activity against ADR resistant breast cancer (MCF-7-ADR) cell line. In vitro cytotoxic activity against ADR resistant breast cancer (MCF-7-ADR) cell line.	[PMID: 10465531]
NCI/ADR-RES	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
NIH3T3	IC₅₀	0.084 μM Compound: podophyllotoxin	Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay	[PMID: 26086179]
NIH3T3	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against mouse NIH/3T3 cells by MTT assay Antiproliferative activity against mouse NIH/3T3 cells by MTT assay	[PMID: 31546197]
OVCAR-3	GI₅₀	11.3 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
OVCAR-3	IC₅₀	0.46 μM Compound: podophyllotoxin	Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span Antitumor activity against human OVCAR-3 cells xenografted in mouse assessed as increase in mouse life span	[PMID: 20187635]
OVCAR-4	GI₅₀	17.5 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR4 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
OVCAR-8	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human OVCAR8 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
P388	ED₅₀	0.003 μg/mL Compound: 12	Cytotoxicity in mouse P388 cells Cytotoxicity in mouse P388 cells	[PMID: 8277312]
P388	ED₅₀	0.0043 μg/mL Compound: 1a	Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
P388	IC₅₀	0.0043 μg/mL Compound: 1 (podophyllotoxin)	Cytotoxicity against P-388 leukemia cells Cytotoxicity against P-388 leukemia cells	[PMID: 10714489]
P388	IC₅₀	0.012 μM Compound: 1	Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line Tested in vitro for antineoplastic activity against P-388 (lymphoid neoplasm from DBA/2 mouse) tumor cell line	[PMID: 14971901]
P388	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against mouse P388 cells after 4 days Cytotoxicity against mouse P388 cells after 4 days	[PMID: 17197187]
P388	IC₅₀	0.012 μM Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 7673931]
P388	IC₅₀	0.012 μM Compound: 1 (Podophyllotoxin)	Antineoplastic activity against P-388 (murine leukemia) cell line. Antineoplastic activity against P-388 (murine leukemia) cell line.	10.1016/0960-894X(95)00432-S
P388	IC₅₀	0.013 μg/mL Compound: 2	Growth inhibition of P388-D1 (murine leukemia) cell line. Growth inhibition of P388-D1 (murine leukemia) cell line.	[PMID: 2002477]
P388	IC₅₀	0.05 μM Compound: 6 (Podophyllotoxin)	Compound was tested for inhibition of cell growth of P-388 cells Compound was tested for inhibition of cell growth of P-388 cells	10.1016/0960-894X(95)00008-H
P388	IC₅₀	10.4 nM Compound: PT	Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay Cytotoxicity against mouse P388 cells assessed as cell viability after 48 hrs by trypan blue exclusion assay	[PMID: 21916509]
P388	IC₅₀	10.4 μM Compound: 185	Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay Cytotoxicity against mouse P388 cells measured after 48 hrs by MTT assay	[PMID: 35598527]
P388	IC₅₀	2900 nM Compound: 2d	In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line	[PMID: 14980682]
P388	IC₅₀	5.9 nM Compound: Podophyllotoxin	Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay	[PMID: 2778449]
PBMC	IC₅₀	5.02 μM Compound: Ref 34, Cpd 1	Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay Cytotoxicity against PBMC (unknown origin) incubated for 24 hrs by CCK8 assay	[PMID: 32992133]
PC-3	ED₅₀	1.2 x 10^-7 μg/mL Compound: podophyllotoxin	Cytotoxicity against human PC3 cells by MTT assay Cytotoxicity against human PC3 cells by MTT assay	[PMID: 7714533]
PC-3	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human PC3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
PC-3	IC₅₀	0.01 μM Compound: podophyllotoxin	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17977727]
PC-3	IC₅₀	0.013 μM Compound: Podophyllotoxin	Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay Antiproliferative activity against androgen-independent prostate cancer PC3 cell line by MTS assay	[PMID: 16213720]
PC-3	IC₅₀	0.034 μM Compound: 2	Cytotoxicity against androgen-independent human PC3 cells Cytotoxicity against androgen-independent human PC3 cells	[PMID: 17256902]
PC-3	IC₅₀	0.05 μM Compound: PPT	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 27187855]
PC-3	IC₅₀	0.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34175586]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 28131777]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 28648953]
PC-3	IC₅₀	0.07 μM Compound: Podophyllotoxin	Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay	[PMID: 29525336]
PC-3	IC₅₀	0.12 μM Compound: PDX	Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Antiproliferative activity against human PC3 cells after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 30482548]
PC-3	IC₅₀	0.2 μM Compound: Podophyllotoxin	Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
PC-3	IC₅₀	10 nM Compound: podophyllotoxin	Antiproliferative activity against human PC3 cells after 72 hrs Antiproliferative activity against human PC3 cells after 72 hrs	[PMID: 17034133]
PC-3	IC₅₀	10 nM Compound: podophyllotoxin	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17197178]
PC-3	IC₅₀	10 nM Compound: podophyllotoxin	Antiproliferative activity against human PC3 cells Antiproliferative activity against human PC3 cells	[PMID: 17482458]
PC-3	IC₅₀	12.5 nM Compound: Podophyllotoxin	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 16441066]
PC-3	IC₅₀	15.8 nM Compound: Ref 34, Cpd 1	Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay	[PMID: 32992133]
PC-3	IC₅₀	18.9 μM Compound: 1	Cytotoxicity against human PC-3 cells by sulforhodamine B assay Cytotoxicity against human PC-3 cells by sulforhodamine B assay	[PMID: 17988764]
PC-3	IC₅₀	3.06 μM Compound: Podophyllotoxin	Antiproliferative activity against human PC3 cells by MTT assay Antiproliferative activity against human PC3 cells by MTT assay	[PMID: 31546197]
PC-3M	IC₅₀	234.9 nM Compound: PPT	Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay Cytotoxicity in human PC-3M cells assessed as inhibition of cell proliferation measured by CCK-8 assay	[PMID: 34098082]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	10 nM Compound: Podophyllotoxin	Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program	[PMID: 15743190]
RAW264.7	IC₅₀	61.3 μg/mL Compound: Podophyllotoxin	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 37550948]
RKO	IC₅₀	0.029 μM Compound: podophyllotoxin	Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay Cytotoxicity against proliferating RKOp27 cells after 72 hrs by Alamar Blue assay	[PMID: 16970401]
RKO	IC₅₀	> 0.5 μM Compound: podophyllotoxin	Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay Cytotoxicity against cell cycle arrested RKOp27 cells after 72 hrs by alamar blue assay	[PMID: 16970401]
RPMI-8226	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human RPMI8226 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
RXF 393	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human RXF393 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Raji	IC₅₀	0.018 μM Compound: B	Cytotoxicity against human Raji cells after 72 hrs by luminescence assay Cytotoxicity against human Raji cells after 72 hrs by luminescence assay	[PMID: 20129783]
SF-268	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF268 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SF-295	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF295 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SF-295	IC₅₀	5.69 μM Compound: 1	Cytotoxicity against human SF295 cells by sulforhodamine B assay Cytotoxicity against human SF295 cells by sulforhodamine B assay	[PMID: 17988764]
SF-539	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SF539 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SGC-7901	IC₅₀	0.34 μM Compound: 1	Cytotoxicity against human SGC7901 cells after 48 hrs Cytotoxicity against human SGC7901 cells after 48 hrs	[PMID: 23022053]
SGC-7901	IC₅₀	2.95 μM Compound: 1	Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay Cytotoxicity against human SGC7901 cells after 72 hrs by MTT assay	[PMID: 22687745]
SH-SY5Y	IC₅₀	1.05 μg/mL Compound: Podophyllotoxin	Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay Anticancer activity against human SH-SY5Y cells after 24 hrs by MTT assay	[PMID: 25305717]
SH-SY5Y	IC₅₀	2.54 μM Compound: 1	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 22687745]
SH-SY5Y	IC₅₀	7 nM Compound: 2, podophyllotoxin	Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method Cytotoxicity against SH-SY5Y cells assessed as cell viability after 48 hrs by MTT method	[PMID: 17765552]
SK-MEL-2	GI₅₀	14.9 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-MEL-28	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-MEL-5	ED₅₀	4.1 x 10^-8 μg/mL Compound: podophyllotoxin	Cytotoxicity against human SK-MEL-5 cells by MTT assay Cytotoxicity against human SK-MEL-5 cells by MTT assay	[PMID: 7714533]
SK-MEL-5	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SK-N-SH	IC₅₀	7.92 μM Compound: 1	Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay Cytotoxicity against human SK-N-SH cells assessed as cell viability by SRB assay	[PMID: 26022842]
SK-N-SH	IC₅₀	< 0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay Cytotoxicity against human SK-N-SH cells assessed as growth inhibition after 48 hrs by SRB assay	10.1039/C0MD00263A
SK-OV-3	ED₅₀	4.2 x 10^-5 μg/mL Compound: podophyllotoxin	Cytotoxicity against human SKOV3 cells by MTT assay Cytotoxicity against human SKOV3 cells by MTT assay	[PMID: 7714533]
SK-OV-3	GI₅₀	0.9 μM Compound: 1	In vitro cytotoxic activity against Ovarian (SK-OV3) cell line. In vitro cytotoxic activity against Ovarian (SK-OV3) cell line.	[PMID: 10465531]
SK-OV-3	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SKOV3 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SN12C	GI₅₀	17.1 nM Compound: PT, NSC 24818	Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SN12C cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SNB-19	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SNB19 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SNB-75	GI₅₀	659.2 nM Compound: PT, NSC 24818	Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SNB75 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SR	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SR cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SW-620	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human SW620 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
SW-620	GI₅₀	2 μM Compound: 1	In vitro cytotoxic activity against colon (SW 620) cancer cell line. In vitro cytotoxic activity against colon (SW 620) cancer cell line.	[PMID: 10465531]
SiHa	IC₅₀	0.1 μM Compound: Podophyllotoxin	Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay Cytotoxicity against human SiHa cells measured after 72 hrs by sulforhodamine B assay	[PMID: 30920216]
T47D	EC₅₀	2.97 nM Compound: PPT	Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay Inhibition of colony formation in human T47D cells after 7 days by crystal violet staining based assay	[PMID: 27187855]
T47D	EC₅₀	8.98 μM Compound: PPT	Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay Antimigratory activity in human T47D cells assessed as inhibition of cell migration after 12 hrs by crystal violet staining based transwell migration assay	[PMID: 27187855]
T47D	GI₅₀	84527.9 nM Compound: PT, NSC 24818	Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human T47D cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
T47D	IC₅₀	0.25 μM Compound: PPT	Antiproliferative activity against human T47D cells after 96 hrs by SRB assay Antiproliferative activity against human T47D cells after 96 hrs by SRB assay	[PMID: 27187855]
THP-1	IC₅₀	19.55 μM Compound: Podophyllotoxin	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 48 hrs by SRB assay	[PMID: 31884407]
TK-10	GI₅₀	30.5 nM Compound: PT, NSC 24818	Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human TK10 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
U-251	GI₅₀	10.7 nM Compound: PT, NSC 24818	Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human U251 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
U-373MG ATCC	ED₅₀	0.004 μg/mL Compound: 12	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8277312]
UACC-257	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UACC257 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
UACC-62	GI₅₀	10 nM Compound: PT, NSC 24818	Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UACC62 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
UO-31	GI₅₀	16.6 nM Compound: PT, NSC 24818	Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay Cytotoxicity against human UO31 cells after 48 hrs by trypan blue dye exclusion assay	[PMID: 22370267]
Vero	CC₅₀	5.74 μM Compound: Podophyllotoxin	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28763644]
Vero	IC₅₀	0.016 μM Compound: podophyllotoxin	Toxicity against monkey Vero cells Toxicity against monkey Vero cells	[PMID: 17618122]
Vero	IC₅₀	0.023 μM Compound: podophyllotoxin	Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay Cytotoxicity against african green monkey Vero cells after 3 days by tetrazolium dye based colorimetric assay	[PMID: 19058972]
Vero	IC₅₀	1.04 μM Compound: Ref 34, Cpd 1	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 32992133]
Vero	IC₅₀	1.78 μM Compound: 1	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 22687745]
Vero	IC₅₀	17 nM Compound: Podo	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 23167812]
WRL68	IC₅₀	1.989 μg/mL Compound: Podophyllotoxin	Anticancer activity against human WRL68 cells after 24 hrs by MTT assay Anticancer activity against human WRL68 cells after 24 hrs by MTT assay	[PMID: 25305717]
WRL68	IC₅₀	3.02 μM Compound: PDT	Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay	[PMID: 29605808]
WRL68	IC₅₀	4.8 μM Compound: podophyllotoxin	Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay Cytotoxicity against human WRL68 cells after 24 hrs by MTT assay	[PMID: 18586491]
ZR-75-1	ED₅₀	0.4 μg/mL Compound: 12	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8277312]

In Vitro

Podophyllotoxin, a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant, has been shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

414.41

Formula

C₂₂H₂₂O₈

CAS No.

518-28-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1OC[C@]2([H])[C@@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(OC)C(OC)=C5)[C@]21[H]

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (241.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4131 mL	12.0653 mL	24.1307 mL
5 mM	0.4826 mL	2.4131 mL	4.8261 mL
10 mM	0.2413 mL	1.2065 mL	2.4131 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (3.02 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (283 KB) SDS (480 KB)

COA (258 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75. [Content Brief]

[2]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31. [Content Brief]

[3]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263. [Content Brief]

[4]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8. [Content Brief]

[5]. Podophyllotoxin

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4131 mL	12.0653 mL	24.1307 mL	60.3267 mL
	5 mM	0.4826 mL	2.4131 mL	4.8261 mL	12.0653 mL
	10 mM	0.2413 mL	1.2065 mL	2.4131 mL	6.0327 mL
	15 mM	0.1609 mL	0.8044 mL	1.6087 mL	4.0218 mL
	20 mM	0.1207 mL	0.6033 mL	1.2065 mL	3.0163 mL
	25 mM	0.0965 mL	0.4826 mL	0.9652 mL	2.4131 mL
	30 mM	0.0804 mL	0.4022 mL	0.8044 mL	2.0109 mL
	40 mM	0.0603 mL	0.3016 mL	0.6033 mL	1.5082 mL
	50 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2065 mL
	60 mM	0.0402 mL	0.2011 mL	0.4022 mL	1.0054 mL
	80 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7541 mL
	100 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.6033 mL

Podofilox Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Podofilox518-28-5PodophyllotoxinMicrotubule/TubulinInhibitorinhibitorinhibit

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Podofilox (Synonyms: Podophyllotoxin)

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