Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila

  • J Nat Prod. 2014 Aug 22;77(8):1976-80. doi: 10.1021/np500390b.
Daniela Reimer  1 ,  Friederike I Nollmann  1 ,  Katharina Schultz  1 ,  Marcel Kaiser  2 ,  Helge B Bode  1
Affiliations
  • 1. Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt , 60438 Frankfurt am Main, Germany.
  • 2. Swiss Tropical and Public Health Institute , Parasite Chemotherapy Socinstraße 57, P.O. Box, CH-4002 Basel, Switzerland.
PMID: 25080196 DOI: 10.1021/np500390b
Abstract

The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.