Methyl ethers of podophyllotoxin-related cyclolignans

  • J Nat Prod. 1995 Jun;58(6):870-7. doi: 10.1021/np50120a008.
J M Miguel del Corral  1 ,  M Gordaliza ,  M A Castro ,  L J Morales ,  J L Lopez ,  A San Feliciano
Affiliations
  • 1. Department of Organic Chemistry, Faculty of Pharmacy, University of Salamanca, Spain.
PMID: 7673931 DOI: 10.1021/np50120a008
Abstract

Methyl ethers of podophyllotoxin [1] and its epimers at positions 7 and 8' were obtained through the corresponding chlorinated or brominated derivatives at position 7. Additionally, the corresponding diol methyl ethers were obtained by reducing the lactone with LiAlH4. 7-O-Methylepipicropodophyllotoxin [12], 7-O-methylpicropodophyllotoxin [13], the diol methyl ethers 15-18 and the corresponding diacetates are described here for the first time. Most of the cyclolignans obtained were evaluated for their cytotoxic activity.