iNOS/TopoI-IN-1
iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM).
For research use only. We do not sell to patients.
- Formula: C34H40AuBrCl2N3OS
- Molecular Weight:886.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Topoisomerase I 2.72 μM (Ki) |
iNOS 1.49 μM (Ki) |
Chemical Information
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Molecular Weight 886.54
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Formula C34H40AuBrCl2N3OS
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SMILES
CC1=CC=C(C)C2=C1N(CCCCCCCCS[Au]C3N(CC(O)C4=CC=CC=C4)C(Cl)=C(Cl)N3C)C5=CC=C(Br)C=C25
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
iNOS/TopoI-IN-1 Related Classifications
HY-162805 Related Classifications
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