Zorubicin
Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas.
For research use only. We do not sell to patients.
- CAS No.: 54083-22-6
- Formula: C34H35N3O10
- Molecular Weight:645.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DNA Polymerase |
Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle[2]. Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human lymphoid cell line
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Concentration:0.1-1 μg/mL
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Incubation Time:0-24 hours
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Result:Time-dependently increased G2-accumulations of human lymphoid cells, delayed the traverse through G1 and the G1-S transition. Caused a stepwise accumulation of cells in G2-phase.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six- to eight-week-old male DBA2 mice with P388 tumour cells[1]
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Dosage:12-18 mg/kg
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Administration:Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection
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Result:Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.
Chemical Information
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CAS No. 54083-22-6
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Molecular Weight 645.66
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Formula C34H35N3O10
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SMILES
OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](/C(C)=N/NC(C5=CC=CC=C5)=O)(O)C[C@@H]4O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O)N
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Synonyms
Rubidazon; Rubidazone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Alberts DS, Van Daalen Wetters T. Rubidazone vs adriamycin: an evaluation of their differential toxicity in the spleen colony assay system. Br J Cancer. 1976 Jul;34(1):64-8. [Content Brief]
[2]. Barlogie B, et al. Kinetic response to cultured human lymphoid cells to rubidazone. J Natl Cancer Inst. 1978 Feb;60(2):279-82. [Content Brief]
[3]. Herman EH, Young RS. Acute cardiovascular alterations induced by low doses of adriamycin, rubidazone, and daunorubicin in the anesthetized beagle dog. Cancer Treat Rep. [Content Brief]
[4]. Sartiano GP, et al. Mechanism of action of the anthracycline anti-tumor antibiotics, doxorubicin, daunomycin and rubidazone: preferential inhibition of DNA polymerase alpha. J Antibiot (Tokyo). 1979 Oct;32(10):1038-45. [Content Brief]
[5]. Akerman KJ, et al. Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I. J Am Chem Soc. 2014 Apr 16;136(15):5670-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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