54083-22-6
Chemical Structure
Zorubicin
Synonym(s): Rubidazon; Rubidazone
- CAS No.: 54083-22-6
- Formula:C34H35N3O10
- Molecular Weight:645.66
IUPAC Name: N'-((E)-1-((2S,4S)-4-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylidene)benzohydrazide
InChIKey: FBTUMDXHSRTGRV-ALTNURHMSA-N
SMILES: OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](/C(C)=N/NC(C5=CC=CC=C5)=O)(O)C[C@@H]4O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O)N
Biological Activity: Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5].
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Zorubicin | Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas. | |||||||||||||||||||||
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References
- [1]. Alberts DS, Van Daalen Wetters T. Rubidazone vs adriamycin: an evaluation of their differential toxicity in the spleen colony assay system. Br J Cancer. 1976 Jul;34(1):64-8. [Content Brief]
- [2]. Barlogie B, et al. Kinetic response to cultured human lymphoid cells to rubidazone. J Natl Cancer Inst. 1978 Feb;60(2):279-82. [Content Brief]
- [3]. Herman EH, Young RS. Acute cardiovascular alterations induced by low doses of adriamycin, rubidazone, and daunorubicin in the anesthetized beagle dog. Cancer Treat Rep. [Content Brief]
- [4]. Sartiano GP, et al. Mechanism of action of the anthracycline anti-tumor antibiotics, doxorubicin, daunomycin and rubidazone: preferential inhibition of DNA polymerase alpha. J Antibiot (Tokyo). 1979 Oct;32(10):1038-45. [Content Brief]
- [5]. Akerman KJ, et al. Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I. J Am Chem Soc. 2014 Apr 16;136(15):5670-82. [Content Brief]
