2. Epigenetics
  3. Histone Methyltransferase
  4. Fagaronine chloride

Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection.

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Fagaronine chloride

Fagaronine chloride Chemical Structure

CAS No. : 52259-64-0

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Fagaronine chloride Related Antibodies

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.1 μM
Compound: 2
Compound was tested for cytotoxicity against A-549 human solid tumor cell line
Compound was tested for cytotoxicity against A-549 human solid tumor cell line
[PMID: 11551768]
HT-29 IC50
9 μM
Compound: 2
Compound was tested for cytotoxicity against HT-29 human solid tumor cell line
Compound was tested for cytotoxicity against HT-29 human solid tumor cell line
[PMID: 11551768]
HeLa IC50
0.39 μg/mL
Compound: 2, fagaronine
Growth inhibition of human HeLa S3 cells after 72 hrs
Growth inhibition of human HeLa S3 cells after 72 hrs
[PMID: 10395504]
KB ED50
0.57 μg/mL
Compound: 1
Cytotoxicity against human KB cells after 48 hrs
Cytotoxicity against human KB cells after 48 hrs
[PMID: 6481359]
KB ED50
0.7 μg/mL
Compound: 1a
The cytotoxic activity was determined against KB cell line.
The cytotoxic activity was determined against KB cell line.
[PMID: 7143376]
L1210 IC50
2 μM
Compound: 1a
Cytotoxicity against murine lymphoblastic leukemia cells (L1210).
Cytotoxicity against murine lymphoblastic leukemia cells (L1210).
[PMID: 8246238]
L1210 IC50
6.6 μM
Compound: 2
Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
[PMID: 20236738]
MCF7 IC50
4 μM
Compound: 2
Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line
Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line
[PMID: 11551768]
P388 ED50
0.18 μg/mL
Compound: 1
Cytotoxicity against mouse P388 cells after 48 hrs
Cytotoxicity against mouse P388 cells after 48 hrs
[PMID: 6481359]
P388 IC50
2 μM
Compound: 1a
Cytotoxicity was measured on murine leukemia p388
Cytotoxicity was measured on murine leukemia p388
[PMID: 8246238]
P388 IC50
> 10 μM
Compound: 1a
Cytotoxicity was measured on murine leukemia p388 CPT 0.3
Cytotoxicity was measured on murine leukemia p388 CPT 0.3
[PMID: 8246238]
Molecular Weight

385.84

Formula

C21H20ClNO4
CAS No.
SMILES

C[N+]1=CC2=CC(OC)=C(C=C2C3=C1C4=CC(OC)=C(C=C4C=C3)O)OC.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fagaronine chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fagaronine52259-64-0Histone MethyltransferaseInhibitorinhibitorinhibit

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