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Art. -Nr.: HY-122532

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Fagaronine chloride

Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection.

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CAS. Nr.: 52259-64-0
Formel: C₂₁H₂₀ClNO₄
Molecular Weight:385.84

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Fagaronine chloride Chemical Structure

CAS. Nr.: 52259-64-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.1 μM Compound: 2	Compound was tested for cytotoxicity against A-549 human solid tumor cell line Compound was tested for cytotoxicity against A-549 human solid tumor cell line	[PMID: 11551768]
Caov-3 cell line	IC₅₀	0.5 μM Compound: 2	Compound was tested for cytotoxicity against CaOv3 human solid tumor cell line Compound was tested for cytotoxicity against CaOv3 human solid tumor cell line	[PMID: 11551768]
HeLa	IC₅₀	0.39 μg/mL Compound: 2, fagaronine	Growth inhibition of human HeLa S3 cells after 72 hrs Growth inhibition of human HeLa S3 cells after 72 hrs	[PMID: 10395504]
HT-29	IC₅₀	9 μM Compound: 2	Compound was tested for cytotoxicity against HT-29 human solid tumor cell line Compound was tested for cytotoxicity against HT-29 human solid tumor cell line	[PMID: 11551768]
KB	ED₅₀	0.57 μg/mL Compound: 1	Cytotoxicity against human KB cells after 48 hrs Cytotoxicity against human KB cells after 48 hrs	[PMID: 6481359]
KB	ED₅₀	0.7 μg/mL Compound: 1a	The cytotoxic activity was determined against KB cell line. The cytotoxic activity was determined against KB cell line.	[PMID: 7143376]
L1210	IC₅₀	2 μM Compound: 1a	Cytotoxicity against murine lymphoblastic leukemia cells (L1210). Cytotoxicity against murine lymphoblastic leukemia cells (L1210).	[PMID: 8246238]
L1210	IC₅₀	6.6 μM Compound: 2	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 20236738]
MCF7	IC₅₀	4 μM Compound: 2	Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line	[PMID: 11551768]
P388	ED₅₀	0.18 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells after 48 hrs Cytotoxicity against mouse P388 cells after 48 hrs	[PMID: 6481359]
P388	IC₅₀	>10 μM Compound: 1a	Cytotoxicity was measured on murine leukemia p388 CPT 0.3 Cytotoxicity was measured on murine leukemia p388 CPT 0.3	[PMID: 8246238]
P388	IC₅₀	2 μM Compound: 1a	Cytotoxicity was measured on murine leukemia p388 Cytotoxicity was measured on murine leukemia p388	[PMID: 8246238]

Chemical Information

CAS. Nr. 52259-64-0
Molecular Weight 385.84
Formel C₂₁H₂₀ClNO₄
SMILES

C[N+]1=CC2=CC(OC)=C(C=C2C3=C1C4=CC(OC)=C(C=C4C=C3)O)OC.[Cl-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. INHIBITION OF RET'ERSE TRANSCRIPTASE ACTII'ITY BY BENZOPHENASTHRIDINE ALKALOIDS

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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