Fagaronine chloride
Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection.
For research use only. We do not sell to patients.
- CAS No.: 52259-64-0
- Formula: C21H20ClNO4
- Molecular Weight:385.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.1 μM
Compound: 2
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Compound was tested for cytotoxicity against A-549 human solid tumor cell line
Compound was tested for cytotoxicity against A-549 human solid tumor cell line
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[PMID: 11551768] |
| Caov-3 cell line | IC50 |
0.5 μM
Compound: 2
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Compound was tested for cytotoxicity against CaOv3 human solid tumor cell line
Compound was tested for cytotoxicity against CaOv3 human solid tumor cell line
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[PMID: 11551768] |
| HeLa | IC50 |
0.39 μg/mL
Compound: 2, fagaronine
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Growth inhibition of human HeLa S3 cells after 72 hrs
Growth inhibition of human HeLa S3 cells after 72 hrs
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[PMID: 10395504] |
| HT-29 | IC50 |
9 μM
Compound: 2
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Compound was tested for cytotoxicity against HT-29 human solid tumor cell line
Compound was tested for cytotoxicity against HT-29 human solid tumor cell line
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[PMID: 11551768] |
| KB | ED50 |
0.57 μg/mL
Compound: 1
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Cytotoxicity against human KB cells after 48 hrs
Cytotoxicity against human KB cells after 48 hrs
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[PMID: 6481359] |
| KB | ED50 |
0.7 μg/mL
Compound: 1a
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The cytotoxic activity was determined against KB cell line.
The cytotoxic activity was determined against KB cell line.
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[PMID: 7143376] |
| L1210 | IC50 |
2 μM
Compound: 1a
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Cytotoxicity against murine lymphoblastic leukemia cells (L1210).
Cytotoxicity against murine lymphoblastic leukemia cells (L1210).
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[PMID: 8246238] |
| L1210 | IC50 |
6.6 μM
Compound: 2
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Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
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[PMID: 20236738] |
| MCF7 | IC50 |
4 μM
Compound: 2
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Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line
Compound was tested for cytotoxicity against MCF-7 human solid tumor cell line
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[PMID: 11551768] |
| P388 | ED50 |
0.18 μg/mL
Compound: 1
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Cytotoxicity against mouse P388 cells after 48 hrs
Cytotoxicity against mouse P388 cells after 48 hrs
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[PMID: 6481359] |
| P388 | IC50 |
>10 μM
Compound: 1a
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Cytotoxicity was measured on murine leukemia p388 CPT 0.3
Cytotoxicity was measured on murine leukemia p388 CPT 0.3
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[PMID: 8246238] |
| P388 | IC50 |
2 μM
Compound: 1a
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Cytotoxicity was measured on murine leukemia p388
Cytotoxicity was measured on murine leukemia p388
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[PMID: 8246238] |
Chemical Information
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CAS No. 52259-64-0
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Molecular Weight 385.84
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Formula C21H20ClNO4
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SMILES
C[N+]1=CC2=CC(OC)=C(C=C2C3=C1C4=CC(OC)=C(C=C4C=C3)O)OC.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fagaronine chloride Related Classifications
HY-122532 Related Classifications
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