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Cat. No.: HY-43565B

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Exatecan intermediate 10

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Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan (HY-13631).Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL) for use in cancer research.

For research use only. We do not sell to patients.

Purity: 99.91%
Formula: C₂₆H₂₄FN₃O₅
Molecular Weight:477.48

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Exatecan intermediate 10 Chemical Structure

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Biological Activity
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- IC₅₀ & Target
Chemical Information
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Biological Activity

Description

Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan (HY-13631).Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2^[1].2 μM (0^[1].975 μg/mL) for use in cancer research^[1].

IC₅₀ & Target

Camptothecins

All ADC Payloads Isoforms :

All Topoisomerase Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 477.48
Formula C₂₆H₂₄FN₃O₅
Color Off-white to light yellow
SMILES

O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)