1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Mc-VC-PAB-SN38

Mc-VC-PAB-SN38 

Cat. No.: HY-131057
Handling Instructions

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mc-VC-PAB-SN38 Chemical Structure

Mc-VC-PAB-SN38 Chemical Structure

CAS No. : 1801838-28-7

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Description

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Camptothecins

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight

991.05

Formula

C₅₁H₅₈N₈O₁₃

CAS No.

1801838-28-7

SMILES

O=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[[email protected]]1(CC)OC(OCC6=CC=C(C=C6)NC([[email protected]@H](NC([[email protected]@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Mc-VC-PAB-SN38Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Mc-VC-PAB-SN38
Cat. No.:
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