2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. BNS-22

BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity.

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BNS-22 Chemical Structure

BNS-22 Chemical Structure

CAS No. : 1151668-24-4

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Based on 1 publication(s) in Google Scholar

BNS-22 Related Antibodies

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Description

BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].
IC50 & Target[1]

topoisomerase II alpha

2.8 μM (IC50, in human)

topoisomerase II beta

0.42 μM (IC50, in human)

In Vitro

BNS-22 (0-30 μM, 24-48 h) can inhibit cell growth and influence on cell cycle progression of the human cervical epidermoid carcinoma cell line HeLa in a dose-dependent manner[1].
BNS-22 (0-30 μM, 0-6 h) does not induce DNA damage and has an antagonistic effect on TOP2 toxin-mediated DNA damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BNS-22 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 24 h, 48 h
Result: Inhibited cell growth with the IC50 value of 4.9 μM after 24 hours and 1.0 μM after 48 hours.

Cell Cycle Analysis[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 24 h
Result: Increased number of cells in G2/M phase.
Disrupted mitotic spindle formation and induced polyploid cell formation at 3 μM.

Western Blot Analysis[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 0, 30 min, 1 h, 2 h, 4 h, 6 h
Result: Decreased etoposide-induced γ-H2AX expression and decreased total cellular TOP2β levels, but not TOP2α levels.
Molecular Weight

407.46

Formula

C24H25NO5
CAS No.
SMILES

O=C1C=C(CCC)C2=C(OC)C=C(OC)C(C(N3CCCC4=C3C=CC=C4)=O)=C2O1
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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BNS-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BNS-221151668-24-4BNS22BNS 22TopoisomeraseTOP2 catalytic inhibitorDNA topoisomerase IITOP2αTOP2βabnormal divisioncancerHeLaInhibitorinhibitorinhibit

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