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Cat. No.: HY-10919

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C-1311

C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.

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CAS No.: 138154-39-9
화학식: C₂₀H₂₂N₄O₂
분자량:350.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

C-1311 Chemical Structure

CAS No.: 138154-39-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

제품 설명

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.14 nM Compound: 5f1, NSC-645809	Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay	[PMID: 21859103]
HCT-116	IC₅₀	4.16 nM Compound: 5f1, NSC-645809	Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay	[PMID: 21859103]
HCT-116	IC₅₀	0.3 μM Compound: C-1311; NSC 645809	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 33191085]
L1210	IC₅₀	0.013 μg/mL Compound: 4k	In vitro inhibitory activity against murine L1210 leukemia In vitro inhibitory activity against murine L1210 leukemia	[PMID: 1732555]
L1210	IC₅₀	0.031 μM Compound: 4k	In vitro inhibitory activity against murine L1210 leukemia In vitro inhibitory activity against murine L1210 leukemia	[PMID: 1732555]
SW480	IC₅₀	0.48 μM Compound: C-1311; NSC 645809	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 33191085]

Chemical Information

CAS No. 138154-39-9
분자량 350.41
화학식 C₂₀H₂₂N₄O₂
SMILES

O=C1C2=C(C=CC(O)=C2)N(C=N3)C4=C3C=CC(NCCN(CC)CC)=C14
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69(5):801-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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C-1311

All Topoisomerase Isoforms

Biological Activity

Chemical Information

순도&문서

References

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C-1311 Related Classifications

HY-10919 Related Classifications