2. Cell Cycle/DNA Damage
  3. Topoisomerase Mitosis
  4. C-1311

C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.

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C-1311

C-1311 Chemical Structure

CAS No. : 138154-39-9

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C-1311 Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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Description

C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.3 μM
Compound: C-1311; NSC 645809
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 33191085]
HCT-116 IC50
1.14 nM
Compound: 5f1, NSC-645809
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 21859103]
HCT-116 IC50
4.16 nM
Compound: 5f1, NSC-645809
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
[PMID: 21859103]
L1210 IC50
0.013 μg/mL
Compound: 4k
In vitro inhibitory activity against murine L1210 leukemia
In vitro inhibitory activity against murine L1210 leukemia
[PMID: 1732555]
L1210 IC50
0.031 μM
Compound: 4k
In vitro inhibitory activity against murine L1210 leukemia
In vitro inhibitory activity against murine L1210 leukemia
[PMID: 1732555]
SW480 IC50
0.48 μM
Compound: C-1311; NSC 645809
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 33191085]
Molecular Weight

350.41

Formula

C20H22N4O2
CAS No.
SMILES

O=C1C2=C(C=CC(O)=C2)N(C=N3)C4=C3C=CC(NCCN(CC)CC)=C14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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C-1311 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-1311138154-39-9C1311C 1311TopoisomeraseMitosisInhibitorinhibitorinhibit

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