MC-AcLys-GDEVD-PABC-Exatecan
MC-AcLys-GDEVD-PABC-Exatecan (MC-AcLys-GDEVD-PABC-DX8951) is a agent-linker conjugate for ADC. MC-AcLys-GDEVD-PABC-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with a novel caspase-3 cleavable peptide linker MC-AcLys-GDEVD-PABC linker. MC-AcLys-GDEVD-PABC-Exatecan can be used to prepare DX8951 antibody conjugate (ADC), and it exhibites significant bystander effect mediated by the caspase-3-triggered extracellular cleavage of the linker, enhancing payload release into the tumor microenvironment.
For research use only. We do not sell to patients.
- Formula: C71H88FN13O20
- Molecular Weight:1462.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Chemical Information
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Molecular Weight 1462.53
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Formula C71H88FN13O20
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SMILES
O=C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(NC1=CC=C(COC(N[C@H]2CCC3=C4C2=C5C(C(N6C5)=CC([C@](CC)(O)C(OC7)=O)=C7C6=O)=NC4=CC(F)=C3C)=O)C=C1)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC(CNC([C@H](CCCCNC(CCCCCN8C(C=CC8=O)=O)=O)NC(C)=O)=O)=O)=O)CCCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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