1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MAC glucuronide phenol-linked SN-38

MAC glucuronide phenol-linked SN-38 

Cat. No.: HY-128943
Handling Instructions

MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.

For research use only. We do not sell to patients.

MAC glucuronide phenol-linked SN-38 Chemical Structure

MAC glucuronide phenol-linked SN-38 Chemical Structure

CAS No. : 2246380-69-6

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Description

MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1091.06

Formula

C₅₀H₅₄N₆O₂₀S

CAS No.

2246380-69-6

SMILES

O=C([[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]](OC2=CC=C(COC(N(COC3=CC=C4N=C5C(CN6C(C(COC([[email protected]@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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MAC glucuronide phenol-linked SN-38
Cat. No.:
HY-128943
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