1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MAC glucuronide phenol-linked SN-38

MAC glucuronide phenol-linked SN-38 

Cat. No.: HY-128943 Purity: 96.26%
Handling Instructions

MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.

For research use only. We do not sell to patients.

MAC glucuronide phenol-linked SN-38 Chemical Structure

MAC glucuronide phenol-linked SN-38 Chemical Structure

CAS No. : 2246380-69-6

Size Price Stock Quantity
1 mg USD 595 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1091.06

Formula

C₅₀H₅₄N₆O₂₀S

CAS No.

2246380-69-6

SMILES

O=C([[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)[[email protected]](OC2=CC=C(COC(N(COC3=CC=C4N=C5C(CN6C(C(COC([[email protected]@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (183.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9165 mL 4.5827 mL 9.1654 mL
5 mM 0.1833 mL 0.9165 mL 1.8331 mL
10 mM 0.0917 mL 0.4583 mL 0.9165 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (4.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (4.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MAC glucuronide phenol-linked SN-38Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product Name:
MAC glucuronide phenol-linked SN-38
Cat. No.:
HY-128943
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