1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. CL2-SN-38

CL2-SN-38 

Cat. No.: HY-126350
Handling Instructions

CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types.

For research use only. We do not sell to patients.

CL2-SN-38 Chemical Structure

CL2-SN-38 Chemical Structure

CAS No. : 1036969-20-6

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Description

CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1627.79

Formula

C₈₂H₁₀₆N₁₂O₂₃

CAS No.

1036969-20-6

SMILES

O=C1N(CC2=C3CC)C(C2=NC4=CC=C(O)C=C34)=CC([[email protected]@](CC)5OC(OCC6=CC=C(NC([[email protected]](CCCCN)NC([[email protected]@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(CNC(C8CCC(CN(C9=O)C(C=C9)=O)CC8)=O)N=N7)=O)=O)CC%10=CC=CC=C%10)=O)=O)C=C6)=O)=C1COC5=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CL2-SN-38Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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CL2-SN-38
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