1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. CL2-SN-38

CL2-SN-38 

Cat. No.: HY-126350 Purity: 98.54%
Handling Instructions

CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types.

For research use only. We do not sell to patients.

CL2-SN-38 Chemical Structure

CL2-SN-38 Chemical Structure

CAS No. : 1036969-20-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 580 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is a DNA topoisomerase I inhibitor. The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1627.79

Formula

C₈₂H₁₀₆N₁₂O₂₃

CAS No.

1036969-20-6

SMILES

O=C1N(CC2=C3CC)C(C2=NC4=CC=C(O)C=C34)=CC([[email protected]@](CC)5OC(OCC6=CC=C(NC([[email protected]](CCCCN)NC([[email protected]@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN7C=C(CNC(C8CCC(CN(C9=O)C(C=C9)=O)CC8)=O)N=N7)=O)=O)CC%10=CC=CC=C%10)=O)=O)C=C6)=O)=C1COC5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (61.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6143 mL 3.0716 mL 6.1433 mL
5 mM 0.1229 mL 0.6143 mL 1.2287 mL
10 mM 0.0614 mL 0.3072 mL 0.6143 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CL2-SN-38Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product Name:
CL2-SN-38
Cat. No.:
HY-126350
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