1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. Topoisomerase
    ADC Cytotoxin
  3. Rebeccamycin

Rebeccamycin 

Cat. No.: HY-19825
Handling Instructions

Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II.

For research use only. We do not sell to patients.

Rebeccamycin Chemical Structure

Rebeccamycin Chemical Structure

CAS No. : 93908-02-2

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Description

Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2].

IC50 & Target[1]

Topoisomerase I

 

Traditional Cytotoxic Agents

 

In Vitro

Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) [1].
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis[3].

In Vivo

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].

Animal Model: CDF1 mice (B16 melanoma, L1210 leukemia)[2]
Dosage: 2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration: I.p.; daily for 9 days
Result: Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
Molecular Weight

570.38

Formula

C₂₇H₂₁Cl₂N₃O₇

CAS No.

93908-02-2

SMILES

O=C(N1)C(C2=C3N([[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]4OC)O)O[[email protected]@H]4CO)C5=C2C=CC=C5Cl)=C(C(C6=CC=C7)=C3NC6=C7Cl)C1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RebeccamycinTopoisomeraseADC CytotoxinantineoplasticantitumorA549HCT-116cellsB16melanomaL1210leukemiaInhibitorinhibitorinhibit

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Rebeccamycin
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HY-19825
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