Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents

  • Bioorg Med Chem Lett. 2010 Aug 1;20(15):4670-4. doi: 10.1016/j.bmcl.2010.05.088.
Nathalie Ayerbe  1 ,  Sylvain Routier ,  Isabelle Gillaizeau ,  Carmen Maiereanu ,  Daniel-Henry Caignard ,  Alain Pierré ,  Stéphane Léonce ,  Gérard Coudert
Affiliations
  • 1. Institut de Chimie Organique et Analytique, UMC CNRS 6005, Orléans cedex 2, France.
PMID: 20566289 DOI: 10.1016/j.bmcl.2010.05.088
Abstract

We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential Anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZs and their cytotoxicity were evaluated on two representative Cancer cell lines. Several derivatives have shown a marked cytotoxicity with IC(50) values in the nanomolar range. Results are reported in this Letter.