NSC 727357 

NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma^[1].

NSC 727357 (<10 μM) induces Top1 cleavage complexes at specific sites, and inhibits Top1 catalytic activity at high concentrations (≥10 μM); it also induces a limited number of Top2-DNA cleavage complexes^[1].
NSC 727357 intercalates into DNA and supercoils it^[1].
NSC 727357 (0.1-5 μM, 18 h) arrests HT29 cells in the G1 phase of the cell cycle^[1].
NSC 727357 exhibits potent antiproliferative activity in the NCI-60 cell line panel with a GI₅₀ value of 0.067 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 727357 (13.4-30 mg/kg, i.p., starting on day 7 after tumor implantation, daily for 5 days) inhibits tumor growth in nu/nuNCr mice bearing LOX-IMVI melanoma xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

648.75

C₄₁H₃₆N₄O₄

910229-23-1

O=C1N(C2=C(C(C3=CC=CC=C23)=O)C4=CC=CC=C41)CCCNCCCNCCCN5C6=C(C(C7=CC=CC=C67)=O)C8=CC=CC=C8C5=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Antony S, et al. Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20.  [Content Brief]