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Staphylococcus+aureu

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (80) Cardiovascular Disease (23) Endocrinology (4) Infection (587) Inflammation/Immunology (78) Metabolic Disease (12) Neurological Disease (19)
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631

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

231

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10486

AIP-II	Bacterial	Infection
AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus .

HY-153695

TXA707	Bacterial	Infection
TXA707 is an FtsZ-targeting antibacterial agent. TXA707 disrupts bacterial septum formation, induces cell enlargement, causes penicillin-binding protein mislocalization, and triggers cell lysis in Staphylococcus aureus cells. TXA707 can be used for the research of Staphylococcus aureus infections .

HY-W141916

Pentaglycine Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Amino Acid Derivatives Bacterial	Infection
Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection .

HY-157362

Tryptone Soya Broth TSB	Biochemical Assay Reagents	Others
Tryptone Soya Broth can be used for MPN determination of Staphylococcus aureus. Tryptone Soya Broth ingredients include tryptone, soy peptone, sodium chloride, dipotassium hydrogen phosphate, and glucose .

HY-P2754

Micrococcal nuclease	Endonuclease	Infection
Micrococcal nuclease is an endonuclease derived from Staphylococcus aureus. Micrococcal nuclease is able to digest both single and double-stranded DNA (ssDNA and dsDNA) and RNA, and can cleave and hydrolyze the AT or AU-rich regions specifically. Micrococcal nuclease could be used as an indicator of Staphylococcus aureus contamination .

HY-P1452A

RNAIII-inhibiting peptideTFA 1 Publications Verification	Bacterial	Infection
RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.

HY-W412175

Coproporphyrin III dihydrochloride 2 Publications Verification Zincphyrin dihydrochloride	Bacterial	Infection
Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit .

HY-W248907

Gentisyl alcohol	Bacterial	Infection
Gentisyl alcohol has anti-Staphylococcus aureus activity .

HY-N11554

(-)-Codonopsine	Bacterial	Infection
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .

HY-108569

nTZDpa	Antibiotic Bacterial PPAR	Infection
nTZDpa is an antibiotic. nTZDpa is a PPARG partial agonist. nTZDpa has antibacterial activity. nTZDpa is effective against growing and persistent Staphylococcus aureus by lipid bilayer disruption .

HY-N8097

Kushenol W	Bacterial	Infection
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-B0930

Efloxate Angorlisin	Bacterial	Infection Cardiovascular Disease
Efloxate (Angorlisin) is a vasodilator used in the research of chronic coronary insufficiency and angina pectoris. Efloxate binds to Staphylococcus aureus sortase A .

HY-142124

Kalimantacin A	Antibiotic Bacterial	Infection
Kalimantacin A is a potent antibiotic. Kalimantacin A shows antibacterial activity against staphylococcus including methicillin-resistant staphylococcus aureus (MRSA) .

HY-156198

Bottromycin A2	Antibiotic Bacterial	Infection
Bottromycin A2 is a natural antibiotic. Bottromycin A2 is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) .

HY-15306S

Eltrombopag-13C4 1 Publications Verification SB-497115-¹³C₄	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-159883

DDHF20	TrxR	Infection
DDHF20 is an antimicrobial agent against Staphylococcus aureus, targeting and inhibiting its thioredoxin reductase (TrxR). It acts as a competitive inhibitor for the NADPH binding site. DDHF20 is expected to be used in research related to antimicrobial infections caused by Staphylococcus aureus .

HY-146458

Antibacterial agent 102	Bacterial Cytochrome P450	Infection
Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC₅₀ value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice .

HY-152097

(S)-ZG197	ClpP Bacterial	Infection
(S)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC₅₀ of 1.4 μM .

HY-116271

Sperabillin C	Antibiotic Bacterial	Infection
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-N2105

(-)-Dicentrine L-Dicentrine	Fungal Bacterial	Infection
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and Candida albicans .

HY-N3789

Dunnianol	Bacterial	Infection
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-170847

Anti-MRSA agent 24	Bacterial	Infection
Anti-MRSA agent 24 (compound 6K) is an antimicrobial agent that targets Staphylococcus aureus (MRSA), especially penicillin-resistant Staphylococcus aureus .

HY-115965

VP-4604	Bacterial Antibiotic	Infection
VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .

HY-115964

VP-4556	Bacterial Antibiotic	Infection
VP-4556 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4556 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 8 µg/mL. VP-4556 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95% .

HY-P5932

Maculatin 1.1 TFA	Bacterial	Infection
Maculatin 1.1 TFA is an antimicrobial peptide with an MIC against Staphylococcus aureus of 7 μM. Maculatin 1.1 TFA can perforate the bacterial membrane of Staphylococcus aureus, causing bacterial death .

HY-115965R

VP-4604 (Standard)	Reference Standards Bacterial Antibiotic	Infection
VP-4604 (Standard) is the analytical standard of VP-4604. This product is intended for research and analytical applications. VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 μg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%[1].

HY-157482

EBP-59	Bacterial	Infection
EBP-59 is a bacterial inhibitor with antibiofilm activity against Gram-positive bacteria. EBP-59 is effective against Staphylococcus aureus and MRSA (methicillin–resistant staphylococcus aureus). EBP-59 can be used to study bacterial infections .

HY-122008

ORM-3819	Bacterial	Infection
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1.

HY-174985

Anti-MRSA agent 32	Bacterial	Infection
Anti-MRSA agent 32 (Compound 26) is an orally active and selective SaClpP (Staphylococcus aureus ClpP protease) activator with an EC₅₀ value of 0.98 μM. Anti-MRSA agent 32 activates SaClpP to abnormally degrade bacterial proteins, inhibiting the proliferation of Staphylococcus aureus. Anti-MRSA agent 32 promotes wound healing in a murine skin infection model. Anti-MRSA agent 32 is promising for research of infectious diseases such as methicillin-resistant Staphylococcus aureus (MRSA) infections .

HY-14926B

Levonadifloxacin arginine (S)-(-)-Nadifloxacin arginine; WCK 771 arginine	Bacterial	Infection
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells .

HY-161069

Anti-infective agent 8	Bacterial	Infection
Anti-infective agent 8 (compound 9d) is an antibacterial agent with an MIC of 0.5 μg/mL against Staphylococcus aureus and Mycobacterium tuberculosis H37Rv. Anti-infective agent 8 has anti-biofilm activity and significantly reduces Staphylococcus aureus biofilm formation .

HY-173197

PBP4-IN-1	Bacterial	Infection
PBP4-IN-1 (Compound 1) is an inhibitor of penicillin-binding protein 4 (PBP4) of Staphylococcus aureus. PBP4-IN-1 enhances the inhibitory activity of antibiotics against PBP2a-mediated methicillin-resistant Staphylococcus aureus (MRSA) by inhibiting the function of PBP4. PBP4-IN-1 can be used for the study of osteomyelitis caused by Staphylococcus aureus and for the study of reversing PBP4-mediated resistance to β-lactam antibiotics.

HY-N14711

Himalomycin A	Antibiotic Bacterial	Infection
Himalomycin A is an anthraquinone antibiotic with strong activity against Staphylococcus aureus, Escherichia coli and Streptomyces vuridochromogenes .

HY-108021

HT-61	Bacterial	Infection
HT-61 is a quinolone antibacterial agent. HT-61 exhibits bactericidal activity against gram-positive bacteria including methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). HT-61 can enhance the effect of Tobramycin (HY-B0441) against Pseudomonas aeruginosa .

HY-17626B

Alalevonadifloxacin hydrochloride WCK-2349 hydrochloride	Antibiotic	Infection
Alalevonadifloxacin (hydrochloride) (WCK-2349 (hydrochloride)) is a oraaly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .

HY-E70230

*Staphylokinase, staphylococcus* aureus** SAK	Ser/Thr Protease	Cardiovascular Disease
Staphylokinase, staphylococcus aureus (SAK) is a fibrin-specific plasminogen activator. Staphylokinase is an efficient, fibrin-selective thrombolytic agent .

HY-N15526

Austroside A	Bacterial	Infection
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .

HY-N14125

Chloroquinocin	Bacterial	Infection
Chloroquinocin has moderate activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) .

HY-P5620

DFTamP1	Bacterial	Infection
DFTamP1 is an antimicrobial peptide against Staphylococcus aureus USA300 activity (MIC is 3.1 μM) .

HY-160669

Antibacterial agent 198	Bacterial	Infection
Antibacterial agent 198 (Compound 16) is an antibacterial agent against gram positive Staphylococcus aureus and strains of Entercoccus .

HY-173240

IPMCL-28b	Bacterial	Infection
IPMCL-28b is an antibacterial agent targeting the bacterial cell membrane. Its minimum inhibitory concentration (MIC) against Staphylococcus aureus ATCC 25923 is 1.56 μg/mL, and the MIC against methicillin-resistant Staphylococcus aureus (MRSA) is 6.25 μg/mL. IPMCL-28b is expected to be used in the research of the anti-infection field .

HY-N10181

11-Keto fusidic acid Simplifusidic acid I	Bacterial	Infection
11-Keto fusidic acid shows strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 μg/mL.

HY-N14416

Parvodicin A	Antibiotic Bacterial	Infection
Parvodicin A is a glycopeptide antibiotic. Parvodicin A has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .

HY-N14768

O-Demethylpaulomycin A	Antibiotic Bacterial	Infection
O-Demethylpaulomycin A is an antibiotic with antibacterial activity. O-Demethylpaulomycin A can inhibit Gram-positive bacteria, especially Staphylococcus aureus .

HY-N14655

Paulomenol A	Bacterial	Infection
Paulomenol A has the effect of anti-Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and so on .

HY-117074

BMS-247243	Antibiotic Bacterial	Infection
BMS-247243 is a β-lactam antibiotic against methicillin (HY-121544)-resistant Staphylococcus aureus.

HY-N14281

Himalomycin B	Antibiotic Bacterial	Infection
Himalomycin B is an anthraquinone antibiotic. Himalomycin B has strong activity against Staphylococcus aureus, Escherichia coli and Streptomyces vuridochromogenes .

HY-163716

Antibacterial agent 222	Bacterial	Infection
Antibacterial agent 222 ((R)-O30 (5)) is a antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA) .

HY-N16444

Sporminarin B	Fungal Bacterial	Infection
Sporminarin B is an antibacterial and antifungal agent. Sporminarin B exhibits inhibitory activity against microorganisms such as Candida albicans and Staphylococcus aureus .

HY-156189

CcpA-IN-1	Antibiotic	Infection
CcpA-IN-1 is a Staphylococcus aureus antibiotic. CcpA-IN-1 has significant bactericidal activity (MICS=460 nM) .

Cat. No.	Product Name	Type

HY-13067G

Celastrol

Tripterine; Tripterin

Fluorescent Dyes

Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-155438

Mal-Cz	Fluorescent Dyes
Mal-Cz is a maltose-derived fluorescence-on imaging probe for the detection of E. coli and Staphylococcus aureus . It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-D3192

CDy11

Fluorescent Dyes

CDy11 is a fluorescent probe and amyloid-binding dye (λ_ex=590 nm; λ_em=612 nm), with a K_a of 29 μM for Pseudomonas aeruginosa Fap. CDy11 specifically recognizes amyloid fibrils in bacterial biofilms and exhibits significantly enhanced fluorescence upon binding to the target. CDy11 shows no staining effect on amyloid-deficient mutant strains, planktonic cells or protein monomers. CDy11 supports in vivo imaging of Pseudomonas aeruginosa biofilms in mouse implant and corneal infection models. CDy11 is widely used in studies of Staphylococcus aureus biofilm infections, dental caries, and Pseudomonas aeruginosa-associated implant and corneal infections .

Cat. No.	Product Name	Type

HY-W110551

2-Methacryloyloxyethyl phosphorylcholine

Biochemical Assay Reagents

2-Methacryloyloxyethyl phosphorylcholine is a polymer monomer containing a phospholipid polar group. 2-Methacryloyloxyethyl phosphorylcholine polymers modify the surface properties of materials and reduce protein-surface interactions, reduce IL-8 production, inhibit cell, Staphylococcus aureus, and Porphyromonas gingivalis adhesion. 2-Methacryloyloxyethyl phosphorylcholine is used in the study of medical device-associated infections, periodontitis, and dental caries .

HY-NP006

Protein A

1 Publications Verification

SPA

Biochemical Assay Reagents

Protein A (SPA) is an immunoglobulin (Ig)-binding protein that exists on the bacterial surface and can be freely secreted into the extracellular environment. Protein A blocks opsonophagocytosis and induces B cell apoptosis in vitro by binding to the Fc region of antibodies and the Fab region of B cell receptors. Protein A can form toxic immune complexes with IgG, thereby inducing leukocyte necrosis. Protein A contributes to the virulence expression of Staphylococcus aureus. Protein A triggers allergic reactions in IgG-pretreated mouse models. Protein A can be used in studies related to immune system diseases .

HY-N8574

1-Heptacosanol

Heptacosan-1-ol

Biochemical Assay Reagents

1-Heptacosanol (Heptacosan-1-ol) is a long-chain fatty alcohol with antifungal, antibacterial (against Escherichia coli and Staphylococcus aureus), nematicidal, anticancer and antioxidant activities. 1-Heptacosanol can be isolated from leaf extracts of Ficus septica and Lecaniodiscus cupanioides. 1-Heptacosanol not only effectively resists pathogenic fungal infections, but also shows potential against pepper anthracnose in phytopathology. 1-Heptacosanol can be used in the research of fungal infections, cancer and oxidative stress-related diseases .

HY-W250308A

ε-Poly-L-lysine hydrochloride (MV 2000-5000)

Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000)

Biochemical Assay Reagents

ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections .

HY-157362

Tryptone Soya Broth TSB	Biochemical Assay Reagents
Tryptone Soya Broth can be used for MPN determination of Staphylococcus aureus. Tryptone Soya Broth ingredients include tryptone, soy peptone, sodium chloride, dipotassium hydrogen phosphate, and glucose .

HY-W001952

6-Bromo-2-naphthol

Biochemical Assay Reagents

6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe that forms a 1:1 or 2:1 complex with β-cyclodextrin (β-CD). 6-Bromo-2-naphthol is capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. RTP probes are a class of small DNA or RNA sequences labeled with fluorescent dyes and quencher molecules, which can be widely used in gene expression analysis, SNP genotyping, and pathogen detection. 6-Bromo-2-naphthol embeds into the cyclodextrin cavity through hydrophobic interactions, inhibits the oxygen quenching effect, and emits a phosphorescent signal at room temperature. 6-Bromo-2-naphthol can also be used as an intermediate for the synthesis of antibacterial azo dyes, and its derivatives show antibacterial activity against Staphylococcus aureus, Escherichia coli and other bacteria .

HY-158223

Carboxymethyl chitosan Methacryloyl

CMCSMA

Biochemical Assay Reagents

Carboxymethyl chitosan Methacryloyl (CMCSMA) is methacrylated carboxymethyl chitosan with properties as a 3D printing ink. A composite hydrogel made of Carboxymethyl chitosan Methacryloyl can effectively accelerate bone healing in an infectious microenvironment after implantation in a rat model of Staphylococcus aureus-infected femoral defect . Carboxymethyl chitosan Methacryloyl needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-13067G

Celastrol

Tripterine; Tripterin

Biochemical Assay Reagents

HY-119491

Ethyl tricosanoate	Biochemical Assay Reagents
Ethyl Tricosanoate is a long-chain saturated fatty acid ethyl ester, which exists in small amounts in C. conicum and C. conicum. Free acid reduces the hemolytic activity of Staphylococcus aureus delta toxin on human erythrocytes. Both ethyl ester and free acid can be used as standards for the analysis of lipid mixtures.

HY-W127485

cis-9,10-Methyleneoctadecanoic Acid

Biochemical Assay Reagents

cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and in the digestive glands of P. globosa. It is a component of the cell membrane of Staphylococcus aureus, and levels were reduced after treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.

HY-179191

Egg-Yolk Salt Agar Medium	Biochemical Assay Reagents
Egg-Yolk Salt Agar Medium is a selective isolation medium for Staphylococcus aureus and needs to be used in conjunction with 10% Egg-Yolk Solution (HY-179192) .

HY-69174

1-Amino-2,5-anhydro-1-deoxy-D-mannitol

Biochemical Assay Reagents

1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial compound with antibacterial activity against a variety of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The application potential of 1-Amino-2,5-anhydro-1-deoxy-D-mannitol lies in its ability to effectively combat common drug-resistant bacterial infections. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol may become an emerging antibacterial agent in clinical inhibition.

Cat. No.	Product Name	Target	Research Area

HY-P2358

PSMα3	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P1883A

Bacterial Sortase Substrate III, Abz/DNP TFA	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP TFA undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P10486

AIP-II	Bacterial	Infection
AIP-II is a cyclic peptide signaling molecule for quorum sensing, which is produced by Staphylococcus aureus. AIP-II potently inhibits AgrC-III in Methicillin (HY-121544)-resistant type III Staphylococcus aureus strain AH1747, with an IC50 of 0.532 nM. AIP-II binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus .

HY-P10724

fMIFL	Formyl Peptide Receptor (FPR) Bacterial	Infection
fMIFL is a formyl tetrapeptide derived from Staphylococcus aureus, and also an agonist of mouse formyl peptide receptor 1 (mFPR1). It exhibits nanomolar activity against mFPR1 and micromolar activity against mFPR2. fMIFL is applicable to studies related to bacterial infections .

HY-P5255

Oligopeptide-10	Bacterial	Infection Inflammation/Immunology
Oligopeptide-10 is a bioactive peptide with antimicrobial activity. Oligopeptide-10 exhibits broad-spectrum bactericidal effects against Gram-positive bacteria including Propionibacterium acnes and Staphylococcus aureus. Oligopeptide-10 targets lipoteichoic acid (LTA) on the surface of bacterial cell membranes, induces bacterial osmotic imbalance by disrupting the integrity of bacterial membranes, and reduces the release of pro-inflammatory cytokines induced by bacteria. Oligopeptide-10 possesses skin-protective activity. Oligopeptide-10 can be applied in research related to acne vulgaris, dandruff, seborrheic dermatitis, and tinea pedis .

HY-W141916

Pentaglycine Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353	Amino Acid Derivatives Bacterial	Infection
Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection .

HY-P2124

Cyclo(L-Trp-L-Trp)	Antibiotic Bacterial	Infection
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .

HY-P4909

Autoinducing Peptide I AIP-I	Peptides	Infection
Autoinducing Peptide I is a cyclic octapeptide secreted by Staphylococcus aureus and can be used in vaccine research .

HY-P1452A

RNAIII-inhibiting peptideTFA 1 Publications Verification	Bacterial	Infection
RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.

HY-W142092

N-Acetyl-DL-serine	Bacterial Endogenous Metabolite	Others
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .

HY-P10364

Ubiquicidin(29-41) UBI(29-41)	Bacterial Antibiotic	Infection Inflammation/Immunology
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P2313

Human β-defensin-2 HβD-2	Antibiotic Bacterial	Infection
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P11165

DRGN-1	Bacterial	Infection
DRGN-1 is an antimicrobial peptide. DRGN-1 exhibits potent antimicrobial and anti-biofilm activities, inhibiting both Gram-negative and Gram-positive bacteria, with an EC₅₀ range of 0.50-4.62 μM. DRGN-1 exerts its antimicrobial effect by disrupting bacterial membrane permeability and slightly depolarizing the membrane potential. DRGN-1 inhibits the formation of biofilms of single bacterial species and mixed species of Pseudomonas aeruginosa and Staphylococcus aureus. DRGN-1 can significantly promote the healing of uninfected and mixed biofilm-infected mouse wounds. DRGN-1 can be used for the study of infections .

HY-P5600

The K4 peptide	Bacterial	Infection
The K4 peptide is an antimicrobial peptide with strong activity against Gram-positive and Gram-negative bacteria, including human pathogenic bacteria, such as Staphylococcus aureus and Marine Vibrio bacteria .

HY-116486

Aureusimine B Phevalin	Peptides	Infection
Aureusimine B (Phevalin) is a cyclic dipeptide. Aureusimine B can be produced by Staphylococcus aureus biofilms. Aureusimine B may be exploited as potential biomarker for chronic, S. aureus biofilm-based infections .

HY-P5561

Aurein 2.2	Antibiotic Bacterial	Infection
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .

HY-P2170

XMP-629 XOMA-629	Antibiotic Bacterial	Infection Inflammation/Immunology
XMP-629 (XOMA-629), a cationic α-helical peptide, is a potent endotoxin inhibitor. XMP-629 exhibits broad-spectrum antimicrobial activity via an immunomodulatory mechanism. XOMA 629 has antimicrobial activity against Propionibacterium acnes, Staphylococcus aureus and Streptococcus pyogenesand .

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-P11191

AR-23	Bacterial	Infection
AR-23 is a melittin-related antimicrobial peptide that can be isolated from Rana tagoi. AR-23 exhibits broad-spectrum growth inhibitory activity against aerobic bacteria, the opportunistic yeast pathogen Candida albicans and clinical isolates of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). AR-23 can be used for antimicrobial research .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-P5446

BMAP-18	Bacterial	Others
BMAP-18 is a biological active peptide. (BMAP-18 is a truncated form of the antimicrobial peptide BMAP-27. Bovine myeloid antimicrobial peptide-27 (BMAP-27) belongs to the Cathelicidin family of peptides which displays rapid bactericidal activity against Staphylococcus aureus, Streptococcus uberis, and Escherichia coli. BMAP-27 is cytotoxic to human erythrocytes and neutrophils, although at higher than microbicidal concentrations. BMAP-18 displays much higher cell selectivity as compared to parental BMAP-27 because of its decreased hemolytic activity and retained antimicrobial activity.)

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .

HY-P5932

Maculatin 1.1 TFA	Bacterial	Infection
Maculatin 1.1 TFA is an antimicrobial peptide with an MIC against Staphylococcus aureus of 7 μM. Maculatin 1.1 TFA can perforate the bacterial membrane of Staphylococcus aureus, causing bacterial death .

HY-P5620

DFTamP1	Bacterial	Infection
DFTamP1 is an antimicrobial peptide against Staphylococcus aureus USA300 activity (MIC is 3.1 μM) .

HY-W714002

Feglymycin	HIV Bacterial	Infection
Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus) .

HY-P5603

Bovine neutrophil beta-defensin 12 BNBD-12	Bacterial	Infection
Bovine neutrophil beta-defensin 12 is an antimicrobial peptide derived from bovine neutrophils, which has antibacterial activity against Escherichia coli and Staphylococcus aureus .

HY-P5670

Maximin 31	Bacterial	Infection
Maximin 31 is an antimicrobial peptide derived from the toad brain. Maximin 31 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 37.5, 75 μg/mL, respectively .

HY-P5638

FLGFVGQALNALLGKL-NH2	Bacterial	Infection
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureus ATCC 29213 (MIC=32 μM) .

HY-P5671

Maximin 32	Bacterial	Infection
Maximin 32 is an antimicrobial peptide derived from the toad brain. Maximin 32 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 9.4, 18.8 μg/mL, respectively .

HY-P5672

Maximin 39	Bacterial	Infection
Maximin 39 is an antimicrobial peptide derived from the toad brain. Maximin 39 is active against Staphylococcus aureus and Escherichia coli, with MIC values of 18.8, 37.5 μg/mL, respectively .

HY-P5718

Brevinin-1PMa	Bacterial	Infection
Brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Brevinin-1PMa also shows hemolytic activity .

HY-P5666

Maximin 15	Bacterial	Infection
Maximin 15 is an antimicrobial peptide derived from the toad brain. Maximin 15 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 9.4, 18.8, 75 μg/mL, respectively .

HY-P5668

Maximin 28	Bacterial	Infection
Maximin 28 is an antimicrobial peptide derived from the toad brain. Maximin 28 is active against Staphylococcus aureus, Escherichia coli and Bacillus subtilis, with MIC values of 4.7, 9.4, 75 μg/mL, respectively .

HY-P2358A

PSMα3 TFA	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 TFA is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 TFA forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 TFA forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 TFA is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P10200

CP7-FP13-2	Bacterial	Infection
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .

HY-P5673

Bombinin H1	Bacterial	Infection
Bombinin H1 is an antimicrobial peptide derived from the skin of moth Bombina variegata. The lethal concentrations of Bombinin H1 against Escherichia coli D21 and Staphylococcus aureus Cowan 1 are 3.8 and 2.1 μM, respectively .

HY-P5676

Bombinin H3	Bacterial	Infection
Bombinin H3 is an antimicrobial peptide derived from the skin of moth Bombina variegata. The lethal concentrations of Bombinin H3 against Escherichia coli D21 and Staphylococcus aureus Cowan 1 are 3.7 and 2.4 μM, respectively .

HY-P5678

Bombinin H4	Bacterial	Infection
Bombinin H4 is an antimicrobial peptide derived from the skin of moth Bombina variegata. The lethal concentrations of Bombinin H4 against Escherichia coli D21 and Staphylococcus aureus Cowan 1 are 4.8 and 3.3 μM, respectively .

HY-P5713

Des(8-14)brevinin-1PMa	Bacterial	Infection
Des(8-14)brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Des(8-14)brevinin-1PMa also shows hemolytic activity .

HY-P10455

Cys-Pexiganan TFA	Bacterial	Infection
Cys-Pexiganan TFA is an amphiphilic antimicrobial peptide. Cys-Pexiganan TFA exhibits antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa, with MIC of 16 μg/mL and 64.0 μg/mL. Cys-Pexiganan TFA interacts with anionic phospholipids and DNA of microbial cell membranes, disintegrates the cells and leads to cell death .

HY-P10539

Hp1404	Bacterial	Infection
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .

HY-P10538

Balteatide	Bacterial Fungal	Infection
Balteatide is an antimicrobial peptide, which can be found in skin secretion of Phyllomedusa baltea. Balteatide inhibits the gram-positive Staphylococcus aureus (MIC=435 μM), the gram-negative Escherichia coli (MIC=109 μM), and Candida albicans (MIC=27 μM). Balteatide lacks hemolytic activity (at 512 mg/L) and myotropic activity .

HY-P5618

Maximin H2	Bacterial	Infection
Maximin H2 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H2 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 2, 4, 2 μg/ml, respectively .

HY-P5655

Maximin H4	Bacterial	Infection
Maximin H4 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H4 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 12, 6, 12, 6 μg/ml, respectively .

HY-P5619

Maximin H3	Bacterial	Infection
Maximin H3 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H3 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 20, 10, 20, 5 μg/ml, respectively .

HY-P5616

Maximin H1	Bacterial	Infection
Maximin H1 is an antimicrobial peptide derived from the skin secretions of Chinese red belly toad Bombina maxima. Maximin H1 has activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC2592, Bacillus pyocyaneus CMCCB1010 and Candida albicans ATCC2002, the MIC values are 9, 4.5, 9, 4.5 μg/ml, respectively .

HY-P11220

Hs02	Bacterial Interleukin Related	Infection
Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 μM, and the MBC is 2-4 μM. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99571

Tefibazumab INH-H 2002	Inhibitory Antibodies	Infection
Tefibazumab is a humanized IgG1κ monoclonal antibody that binds to the surface-expressed adhesion protein clumping factor A. Tefibazumab can be used for the research of serious Staphylococcus aureus infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4117

Hamamelitannin	Infection Hamamelis mollis Oliver Classification of Application Fields Phenols Polyphenols Hamamelidaceae Plants Disease Research Fields Source Classification	Bacterial
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-N2594

Isoforsythiaside	Infection Oleaceae Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Disease Research Fields Source Classification	Bacterial
Isoforsythiaside is an antioxidant and antibacterial phenylethanoid glycoside with MICs of 40.83, 40.83, and 81.66 μg/mL for Escherichia coli(E. coli), Pseudomonas aeruginosa(PAO), and Staphylococcus aureus (SA), respectively .

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-129434A

4aα,7α,7aα-Nepetalactone 1 Publications Verification	Infection other families Iridoids Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	Bacterial
4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.

HY-N15451

Deoxytopsentin	Structural Classification Alkaloids Marine natural products Sponge Indole Alkaloids Source Classification	Pyruvate Kinase
Deoxytopsentin (compound 5) is a marine bisindole alkaloid and also a MRSA pyruvate kinase inhibitor. Deoxytopsentin exists in sponges. Deoxytopsentin exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus strains in vitro .

HY-W248907

Gentisyl alcohol	Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Disease Research Source Classification	Bacterial
Gentisyl alcohol has anti-Staphylococcus aureus activity .

HY-N11554

(-)-Codonopsine	Structural Classification Alkaloids Pyrrole Alkaloids Campanulaceae Codonopsis pilosula (Franch.) Nannf. Plants Source Classification	Bacterial
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .

HY-N8097

Kushenol W	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Bacterial
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-142124

Kalimantacin A	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Kalimantacin A is a potent antibiotic. Kalimantacin A shows antibacterial activity against staphylococcus including methicillin-resistant staphylococcus aureus (MRSA) .

HY-156198

Bottromycin A2	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Bottromycin A2 is a natural antibiotic. Bottromycin A2 is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) .

HY-N1307

Sideroxylonal A 1 Publications Verification	Phenols Polyphenols Myrtaceae Eucalyptus sideroxylon A.Cunn. ex Woolls Plants Source Classification	Bacterial
Sideroxylonal A is an effective marine antifouling agent isolated from Eucalyptus jensenii. Sideroxylonal A has antibacterial activity against the Gram-positive bacteria Staphylococcus aureus and Bacilus subtilis .

HY-N3515

Multicaulisin	Infection Flavonoids Classification of Application Fields Phenols Polyphenols Morus multicaulis Plants Moraceae Disease Research Fields Isoflavones Source Classification	Bacterial
Multicaulisin, a new Diels-Alder type adduct from Morus multicaulis roots, potently effects against Staphylococcus aureus (MRSA) isolates. Multicaulisin is an antibacterial agent and has the potential for MRSA infections research .

HY-116271

Sperabillin C	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .

HY-N2105

(-)-Dicentrine L-Dicentrine	Structural Classification Alkaloids Aporphine Alkaloids Plants Menispermaceae Source Classification Stephania sinica Diels	Fungal Bacterial
(-)-Dicentrine is an aporphine alkaloid that can be isolated from the stem bark of Talauma arcabucoana. (-)-Dicentrine shows moderate growth inhibition against Staphylococcus aureus and Candida albicans .

HY-N16461

Albomycin ε	Structural Classification Microorganisms Antibiotics Source Classification	Bacterial
Albomycin ε is a siderophore-antibiotic conjugate targeting bacterial ribosomes (MIC values:>512 μg/mL). Albomycin ε is promising for research of Streptococcus pneumoniae and Staphylococcus aureus infections .

HY-116486

Aureusimine B Phevalin	Structural Classification Natural Products Microorganisms Source Classification	Others
Aureusimine B (Phevalin) is a cyclic dipeptide. Aureusimine B can be produced by Staphylococcus aureus biofilms. Aureusimine B may be exploited as potential biomarker for chronic, S. aureus biofilm-based infections .

HY-125652

Macrosphelide A	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Antibiotic
Macrosphelide A is a macrolide antibiotic. Macrosphelide A inhibits growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a MIC of ≤500 μg/mL .

HY-N12179

Brevianamide M	Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Endogenous metabolite Source Classification	Bacterial
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

HY-N8406

Monomethylsulochrin	Microorganisms Phenols Source Classification	Bacterial Antibiotic
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .

HY-N7010

(-)-Corynoxidine	Infection Alkaloids Classification of Application Fields Corydalis speciosa Maxim. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Cholinesterase (ChE) Bacterial
(-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC₅₀ value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa . (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees .

HY-N3789

Dunnianol	Infection Classification of Application Fields Lignans Illicium dunnianum Tutch. Phenols Polyphenols Illiciaceae Phenylpropanoids Plants Disease Research Fields Source Classification	Bacterial
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-N14711

Himalomycin A	Quinones Microorganisms Anthraquinones Source Classification	Antibiotic Bacterial
Himalomycin A is an anthraquinone antibiotic with strong activity against Staphylococcus aureus, Escherichia coli and Streptomyces vuridochromogenes .

HY-N15526

Austroside A	Annona squamosa L. Plants Annonaceae Saccharides Monosaccharides Source Classification	Bacterial
Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain .

HY-N14125

Chloroquinocin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Chloroquinocin has moderate activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) .

HY-N14416

Parvodicin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Parvodicin A is a glycopeptide antibiotic. Parvodicin A has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .

HY-N14768

O-Demethylpaulomycin A	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
O-Demethylpaulomycin A is an antibiotic with antibacterial activity. O-Demethylpaulomycin A can inhibit Gram-positive bacteria, especially Staphylococcus aureus .

HY-N14655

Paulomenol A	Microorganisms Antibiotics Source Classification	Bacterial
Paulomenol A has the effect of anti-Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and so on .

HY-N14281

Himalomycin B	Quinones Structural Classification Microorganisms Antibiotics Anthraquinones Source Classification	Antibiotic Bacterial
Himalomycin B is an anthraquinone antibiotic. Himalomycin B has strong activity against Staphylococcus aureus, Escherichia coli and Streptomyces vuridochromogenes .

HY-N16444

Sporminarin B	Natural Products Microorganisms Source Classification	Fungal Bacterial
Sporminarin B is an antibacterial and antifungal agent. Sporminarin B exhibits inhibitory activity against microorganisms such as Candida albicans and Staphylococcus aureus .

HY-N14665

Atrovenetin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Atrovenetin is an antibiotic found in Penicillium species. Atrovenetin has inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.

HY-N13885

Amythiamicin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Parasite
Amythiamicin A is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .

HY-N15418

Mikanolide	Terpenoids Sesquiterpenes Plants Compositae Leptoderris fasciculata (Benth.) Dunn Source Classification	Antibiotic Bacterial
Mikanolide is a sesquiterpene that has antibacterial properties. Mikanolide inhibits the growth of Staphylococcus aureus with a zone of 14 mm at a concentration of 100 μg per disk .

HY-N14118

Chloropolysporin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Chloropolysporin B has strong activity of anti-Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and enterococcus bacteria .

HY-N6846

10-Isobutyryloxy-8,9-epoxythymol isobutyrate	Infection Natural Products Classification of Application Fields Inula helenium L. Plants Compositae Disease Research Fields Source Classification	Bacterial
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .

HY-N14673

Helvecardin A	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Helvecardin A is a glycopeptidtic antibiotic. Helvecardin A has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus .

HY-N14974

Ericamycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Ericamycin is an antibiotic that exhibits antibacterial activity against Gram-positive activity, inhibits Staphylococcus aureus with MIC of 0.004-0.016 µg/mL .

HY-N13881

Amythiamicin C	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Parasite
Amythiamicin C is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .

HY-N13998

Cephalonic acid	Other Terpenoids Microorganisms Terpenoids Source Classification	Bacterial
Cephalonic acid is a pentaprenyl terpenoid compound that can be isolated from the fermentation broth of Cephaloscorlum caerulens. Cephalonic acid has weak antibacterial activity against Staphylococcus aureus .

HY-N14871

Pyrronamycin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Pyrronamycin A has antibacterial activity against Gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella .

HY-N5181

Parvodicin C3	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Parvodicin C3 is a glycopeptide antibiotic. Parvodicin C3 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .

HY-N12421

Paulomycin A Volonomycin A	Microorganisms Antibiotics Source Classification	Bacterial
Paulomycin A (Volonomycin A) has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .

HY-N15040

Parvodicin C4	Natural Products Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Parvodicin C4 is a glycopeptide antibiotic. Parvodicin C4 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .

HY-N8443

Isoaltenuene	Microorganisms Terpenoids Sesquiterpenes Source Classification	Bacterial
Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .

HY-N14470

Kigamicin A	Natural Products Microorganisms Source Classification	Bacterial
Kigamicin A shows activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.025-0.78 μg/mL .

HY-N8186

(3R)-7,4’-Dihydrohomoisoflavanone	Infection Flavonoids Dracaena cambodiana Pierre ex Gagnep. Classification of Application Fields Flavonones Phenols Polyphenols Agavaceae Plants Disease Research Fields Source Classification	Bacterial
(3R)-7,4’-Dihydrohomoisoflavanone is a natural product with antibacterial activities against S. aureus and *methicillin-resistant Staphylococcus aureus* (MRSA)** .

HY-N14476

Kigamicin B	Natural Products Microorganisms Source Classification	Bacterial
Kigamicin B shows activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.025-0.78 μg/mL .

HY-N14657

Paulomycin A2	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Paulomycin A2 has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .

HY-N14675

Helvecardin B	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Helvecardin B is a glycopeptidtic antibiotic. Helvecardin B has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus .

HY-N14706

Kibdelin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

HY-N14707

Kibdelin B	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .

Cat. No.	Product Name	Chemical Structure

HY-B1777AS

Spermine-d8 tetrahydrochloride

Spermine-d₈ (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-17586AS

Dalbavancin-d6
Dalbavancin-d₆ is the deuterium labeled Dalbavancin . Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .

HY-B1455S1

Clindamycin-13C,d3

Clindamycin- ¹³C,d₃ is the ¹³C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

HY-15306S

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-W654157

Dicloxacillin-13C4 sodium hydrate
Dicloxacillin- ¹³C₄ sodium hydrate is the ¹³C-labeled Dicloxacillin Sodium hydrate (HY-B0977). Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to study infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .

HY-B0960S

Sulfabenzamide-d4

Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-14814S

Delafloxacin-d5
Delafloxacin-d₅ is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .

HY-B1455S

Clindamycin-d3 hydrochloride

Clindamycin-d₃ (hydrochloride) is the deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

HY-B1777S

Spermine-15N2

Spermine- ¹⁵N₂ (NSC 268508- ¹⁵N₂) is the ¹⁵N-labeled Spermine (HY-B1777). Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-N8443S

Isoaltenuene-d6
Isoaltenuene-d₆ is deuterium labeled Isoaltenuene. Isoaltenuene is an anti-bacterial agent with moderate activity against Staphylococcus aureus. Isoaltenuene can be isolated from fungus Alternaria alternate cib-137 .

HY-B1459AS

Dicloxacillin-13C4
Dicloxacillin- ¹³C₄ is the ¹³C labeled Dicloxacillin (HY-B1459A) . Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .

HY-W716702

Aldox-d6

Aldox-d₆ (Lexamine M-13-d₆; MAPD-d₆) is the deuterium labeled Myristamidopropyl dimethylamine (HY-W099582). Myristamidopropyl dimethylamine (MAPD) is an antimicrobial agent (including against bacteria and fungi) and an insecticide, exhibiting inhibitory activity against Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Fusarium solani, and Acanthamoeba polyphaga. Myristamidopropyl dimethylamine can be used in research on microbial-induced keratitis .

HY-W012531S2

2-Hydroxycinnamic acid-d4

2-Hydroxycinnamic acid-d₄ is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity .

HY-W713365

Eltrombopag-d3

Eltrombopag-d₃ (SB-497115-d₃) is deuterium labeled Eltrombopag. Eltrombopag (SB-497115) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well .

HY-W756467

Antibacterial agent 265-13C,d3

Antibacterial agent 265- ¹³C,d₃ (1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid- ¹³C,d₃) is the deuterium labeled and ¹³C-labeled Antibacterial agent 265 (HY-W018629). Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans .

HY-B0506S1

Nadifloxacin-d5

Nadifloxacin-d₅ (OPC7251-d₅) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

HY-W012444S

Glyceryl 1-monooctanoate-d15

Glyceryl 1-monooctanoate-d₁₅ is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .

HY-W704402

Glyceryl 1-monooctanoate-d5

Glyceryl 1-monooctanoate-d₅ is the deuterium labeled Glyceryl 1-monooctanoate (HY-W012444). Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria .

Cat. No.	Product Name		Classification

HY-155438

Mal-Cz		Azide
Mal-Cz is a maltose-derived fluorescence-on imaging probe for the detection of E. coli and Staphylococcus aureus . It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-174333

CYP1A1-IN-1		Alkynes
CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria .

HY-N16526

Juncatrin B		Alkynes
Juncatrin B is a type of dihydrophenanthrene compound. Juncatrin B exhibits inhibitory activity against both Methicillin (HY-121544)-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA). Juncatrin B can inhibit the formation of biofilms in MSSA and MRSA. Juncatrin B has no significant activity against Gram-negative bacteria. Juncatrin B can be used in the research of anti-Staphylococcus aureus .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13067G

Celastrol Tripterine; Tripterin	Endogenous Metabolite Proteasome Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Inflammation/Immunology Cancer
Celastrol (GMP) (Tripterine (GMP)) is Celastrol (HY-10227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant *Staphylococcus aureus* (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

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