1. Anti-infection
  2. Bacterial
  3. (3R,4R)-A2-32-01

(3R,4R)-A2-32-01 

Cat. No.: HY-111532 Purity: 99.28%
Handling Instructions

(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity.

For research use only. We do not sell to patients.

(3R,4R)-A2-32-01 Chemical Structure

(3R,4R)-A2-32-01 Chemical Structure

CAS No. : 1359752-95-6

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity[1].

In Vitro

(3R,4R)-A2-32-01 inhibits hemolysis with an ED50 of 15 nmol on blood agar plates[1].
(3R,4R)-A2-32-01 exhibits EC50s of 50 μM and 75 μM in dropping metabolic activity of NIH3T3 fibroblasts and HaCat keratinocytes, respectively[1].

Molecular Weight

301.42

Formula

C₁₉H₂₇NO₂

CAS No.

1359752-95-6

SMILES

O=C1O[[email protected]](CCC2=CC=CN=C2)[[email protected]]1CCCCCCCC=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (663.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3176 mL 16.5882 mL 33.1763 mL
5 mM 0.6635 mL 3.3176 mL 6.6353 mL
10 mM 0.3318 mL 1.6588 mL 3.3176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (16.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (16.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (16.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(3R,4R)-A2-32-01Bacterialanti-virulencelactonetolerablecytotoxicitybacterialenzymeinfectionInhibitorinhibitorinhibit

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Product Name:
(3R,4R)-A2-32-01
Cat. No.:
HY-111532
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