AgrC-IN-1 

AgrC-IN-1 is an AgrC inhibitor with an IC₅₀ of 3.5 μM against Staphylococcus aureus AgrC. AgrC-IN-1 competitively binds to AgrC, inhibiting its autophosphorylation activity in Staphylococcus aureus. AgrC-IN-1 inhibits quorum sensing in Staphylococcus aureus, blocking virulence factor production. AgrC-IN-1 can be used for the research of Staphylococcus aureus infections^[1].

AgrC-IN-1 (CP-20) (16 μM) completely inhibits P3 transcription in the agr-null background Staphylococcus aureus group-I strain with isolated AgrC/A signal transduction system, strongly suggesting it targets AgrC or AgrA^[1].
AgrC-IN-1 has no significant effect on the luminescence activity mediated by AgrA:DNA binding in the Staphylococcus aureus strain with agr operon replaced by luciferase reporter^[1].
AgrC-IN-1 causes a dose-dependent decrease in AgrC autophosphorylation level when co-incubated with AIP-I in the Staphylococcus aureus AgrC nanodisc system, directly inhibiting AgrC autophosphorylation^[1].
AgrC-IN-1 (10 μM) displaces 375 nM TAMRA-AIP-III D4A from Staphylococcus aureus AgrC nanodiscs and reduces the fluorescence polarization signal by 52%, indicating its binding to AgrC and competitive occupation of the binding site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

418.92

C₁₈H₁₅ClN₄O₂S₂

1448066-54-3

ClC1=CC(NC(N2CCC(N=C(NC(C3=CSC=C3)=O)S4)=C4C2)=O)=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Polaske TJ, et al. A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus. J Am Chem Soc. 2026 Mar 11;148(9):9199-9204.