2. Anti-infection
  3. Bacterial
  4. CHIR-29498

CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus.

For research use only. We do not sell to patients.

CHIR-29498

CHIR-29498 Chemical Structure

CAS No. : 236102-25-3

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CHIR-29498 Related Antibodies

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Description

CHIR-29498 is an antibacterial peptoid. CHIR-29498 is active against both Gram-positive and Gram-negative bacteria. CHIR-29498 can be used for the study of fatal Staphylococcus aureus[1].

In Vitro

CHIR-29498 (0.6-40 μM, 18-24 h) is active against both Gram-positive and Gram-negative bacteria[1].
CHIR-29498 (20-40 μM) can continuously increase the extracellular β-galactosidase activity of Escherichia coli ML-35 (ATCC 43827), indicating cell membrane leakage[1].
CHIR-29498 (20-40 μM, 0.5-2 h) causes 54.4% (1× MIC) and 74.2% (2× MIC) of Staphylococcus aureus ATCC 25923 to be stained with PI after incubation for 30 minutes; after 2 hours, the staining percentages increased to 78.1% and 94.1%, respectively, indicating increased membrane permeability. The effect of DHAA is relatively weak[1].
CHIR-29498 (1 h) induces hemolysis in mice (BALB/c) or human erythrocytes (RBCs) at concentrations above the MIC, but the hemolytic activity is mild[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHIR-29498 Related Antibodies
In Vivo

CHIR-29498 (5-30 mg/kg, i.p., once) shows complete protection at doses of 10 mg/kg and 30 mg/kg in CD-1 mice, and also shows activity in delayed dosing scenarios where infection has been established[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice (weighing approximately 25 grams) were inoculated with approximately 108 CFU of bacteria via intraperitoneal injection[1].
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: I.p., once
Result: Protected 100% of the animals at a dose of 10 mg/kg.
Protected 50% of the animals when dosed (30 mg/kg) 110 min after i.p. infection.
Molecular Weight

629.88

Formula

C38H55N5O3
CAS No.
SMILES

O=C(N(CC(N)=O)C1CCCC2=C1C=CC=C2)CN(CCN)C(CNC[C@]3(C)CCC[C@]4(C)C5=C(CC[C@@]34[H])C=C(C(C)C)C=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHIR-29498 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIR-29498236102-25-3CHIR29498CHIR 29498BacterialPeptoidsDehydroabietylamineDHAAInhibitorinhibitorinhibit

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